Enhanced high resolution breast imaging device and method utilizing non-ionizing radiation of narrow spectral bandwidth

• US 5,999,836 A
• Filed: 02/02/1996
• Issued: 12/07/1999
• Est. Priority Date: 06/06/1995
• Status: Expired due to Fees

• Current Assignee: Nelson, Robert S., Reuven D. Zach
• Original Assignee: Nelson, Robert S., Reuven D. Zach
• Inventors: Nelson, Robert S., Zach, Reuven D.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/597,447
• Time in Patent Office: 1,404 Days
• Field of Search: 600/425, 600/427, 600/443, 600/448, 600/459, 600/476, 600/473, 600/407, 250/341.1, 250/341.7, 250/339.02, 250/358.1, 250/360.1
• US Class Current: 600/407
• CPC Class Codes: A61B 5/0053 by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
• CPC Class Codes: A61B 5/0064 Body surface scanning
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence

Abstract

The present invention provides a method and apparatus for high resolution breast imaging using collimated non-ionizing acoustic radiation and electromagnetic radiation in the near ultraviolet, visible, infrared and microwave regions (i.e. "light") rather than ionizing x-radiation. The light used is of a narrow spectral bandwidth in that the optical properties of interest are relatively uniform over the bandwidth. The incident collimated light is transmitted through and backscattered out of a breast. Normal and diseased breast materials exhibit comparatively distinct characteristics when exposed to radiation and are thereby differentiated. Collimation can also be used to control the level of scattered radiation. Radiation coupling materials can be employed during image acquisition to enhance radiation coupling into and out of the breast as well as providing desirable absorption and scattering properties. Additional scatter reduction and/or improved sensitivity can be attained by compressing a region of the breast using contoured and/or flat compression plates of various sizes which may include an open region allowing access to the surface of the breast for irradiating a portion of the breast. An acoustic field can be introduced into a volume of breast tissue altering its optical qualities. These changes can be recorded by intersecting an optical field with the acoustic field, providing spatial information and tissue characterization.

Claims

1. A mammography imaging apparatus using non-ionizing radiation comprising:

at least one source of non-ionizing radiation of relatively narrow spectral bandwidth disposed such that the radiation from said at least one source will be incident on a portion of the breast to be scanned,

at least one radiation detector disposed so as to detect radiation having passed through the portion of the breast to be scanned,

a collimator corresponding to each detector and adapted to be disposed between the portion of the breast to be scanned and each detector,

a radiation imager for translating said detected radiation into a mammography image, and

a structure for enabling shaping at least a region of the breast and for providing compression to the breast, said structure being positionable adjacent the breast, and said structure having at least one open region enabling access to a surface of the breast, the surface of the breast accessible through said at least at least one open region substantially defining a plane wherein the structure is configured to provide compression to the breast in a direction substantially perpendicular to said plane of the surface of the breast accessible through said at least one open region.

2. The apparatus of claim 1 wherein said at least one source of non-ionizing radiation of relatively narrow spectral bandwidth is disposed such that the radiation from said at least one source will be incident over a plurality of angles on the portion of the breast to be scanned.

3. The apparatus of claim 2 further comprising

at least one additional source of non-ionizing radiation disposed such that the radiation from said additional source is incident over a plurality of angles of the portion of the breast to be scanned,

at least one additional detector corresponding to and disposed to detect radiation from the at least one additional source after said radiation exits the portion of the breast, and

at least one additional collimator corresponding to each additional detector and adapted to be disposed between the portion of the breast to be scanned and said corresponding additional detector.

4. The apparatus of claim 3 wherein the at least one additional source is a source of acoustic radiation.

5. The apparatus of claim 4 wherein the at least one additional detector corresponding to the acoustical radiation source is at least one of a deformable mirrored deflection plate, a reflective elastic layer, and a bladder.

6. The apparatus of claim 4 wherein the at least one additional detector corresponding to the acoustical radiation source is a bladder comprising a structure for shaping at least a region of the breast and for providing compression to the breast.

7. The apparatus of claim 1 wherein the at least one source comprises at least one of an optical radiation source and an acoustical radiation source.

8. The apparatus of claim 1 wherein said at least one source comprises an acoustical radiation source emitting acoustical radiation, said acoustical radiation detectable by at least one detector comprising at least one of a deformable mirrored deflection plate, a reflective elastic layer, and a bladder.

9. The apparatus of claim 8 wherein said at least one detector comprises a bladder configured to detect acoustical radiation exiting the portion of the breast, said bladder positionable adjacent the breast.

10. The apparatus of claim 9 wherein said bladder includes an acoustic transducer.

11. The apparatus of claim 9 wherein the bladder comprises at least one of a deformable mirrored deflection plate and a reflective elastic layer.

12. The apparatus of claim 9 wherein the bladder comprises a structure for shaping at least a region of the breast and for providing compression to the breast.

13. The apparatus of claim 1 wherein the structure comprises two plates of substantially the same size.

14. The apparatus of claim 13 wherein the two plates can be moved in tandem along the breast to be scanned during image acquisition.

15. The apparatus of claim 1 wherein the structure comprises two plates of different sizes.

16. The apparatus of claim 15 wherein at least one plate can be moved during image acquisition.

17. The apparatus of claim 16 wherein the structure is contoured and provides at least one of gradual compression to the breast, a flat radiation entrance surface, and steep compression to the breast.

18. The apparatus of claim 1 wherein the apparatus is configured such that said at least one source of non-ionizing radiation of relatively narrow spectral bandwidth is disposed such that the radiation from said at least one source will be incident on a portion of the breast to be scanned having a volume less than a volume of the entire breast.

19. The apparatus of claim 1 wherein the structure for enabling shaping at least a region of the breast and for providing compression to the breast is substantially transparent to non-ionizing radiation.

20. The apparatus of claim 1 wherein the structure is contoured and provides at least one of gradual compression to the breast, a flat radiation entrance surface, and steep compression to the breast.

21. A method for obtaining mammography images of a portion of the breast using non-ionizing radiation comprising the steps of:

(1) positioning a structure for enabling shaping at least a region of the breast and for providing compression to the breast proximate to the breast to be scanned, said structure having at least one open region enabling access to a surface of the breast the surface of the breast accessible through said at least one open region substantially defining a plane;

(2) compressing the breast with the structure in a direction substantially perpendicular to said plane the surface of the breast accessible through said at least one open region;

(3) irradiating the portion of the breast with non-ionizing radiation of a relatively narrow spectral bandwidth, said radiation incident on the portion of the breast at a plurality of angles;

(4) allowing the radiation to transmit through the portion of the breast;

(5) collimating the radiation;

(6) detecting at least one of transmitted radiation, backscattered radiation, virtual collimated transmitted radiation, virtual collimated backscattered radiation, radiation due to emission fluorescence, radiation due to Raman scattering, and radiation due to Doppler scattering with a radiation detector; and

(7) translating the detected radiation into a mammography image of the portion of the breast.

22. The method of claim 21 wherein the step of irradiating the portion of the breast with non-ionizing radiation of a relatively narrow spectral bandwidth comprises

(1) positioning at least one source of non-ionizing radiation of relatively narrow spectral bandwidth proximate the surface of the breast accessible through said at least one open region in said structure;

and

(2) irradiating the portion of the breast with non-ionizing radiation of a relatively narrow spectral bandwidth from the source.

23. The method of claim 21 including the additional step of introducing a coupling material of suitable index of refraction between the source of non-ionizing radiation and the surface of the breast.

24. The method of claim 21 wherein the optically transparent structure comprises two plates of substantially the same size, the method including the additional step of moving the two plates of the optically transparent structure in tandem simultaneously with irradiating the portion of the breast.

25. The method of claim 21 wherein the optically transparent structure comprises two plates of substantially different size, including the additional step of moving at least one plate of the optically transparent structure simultaneously with irradiating the portion of the breast.

26. The method of claim 21 wherein the portion of the breast imaged has a volume less than a volume of the whole breast.

27. The method of claim 21 wherein steps 1-7 are repeated for a plurality of portions of the breast to be scanned.

28. The method of claim 27 including the additional step of combining the mammography image formed for each portion of the breast to be imaged into a complete image of the breast.

29. The method of claim 21 wherein the structure comprises a contoured compression plate and the step of compressing the breast provides at least one of gradual compression to the breast, a flat radiation entrance surface, and steep compression of the breast.