Apparatus for measuring circulating blood volume

• US 5,999,841 A
• Filed: 08/22/1997
• Issued: 12/07/1999
• Est. Priority Date: 12/17/1993
• Status: Expired due to Term

• Current Assignee: Nihon Kohden Corporation
• Original Assignee: Nihon Kohden Corporation
• Inventors: Kobayashi, Naoki, Aoyagi, Takuo, Kanemoto, Michio
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US08/916,295
• Time in Patent Office: 837 Days
• Field of Search: 600/481, 600/431, 600/479, 600/507, 600/310, 600/432, 600/473, 600/476, 600/504, 600/526
• US Class Current: 600/431
• CPC Class Codes: A61B 5/0275 using tracers, e.g. dye dilution

Abstract

Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.

Claims

1. An apparatus for determining a circulating blood volume comprising:

dye density measuring means for continuously measuring dye density of an infected dye in said circulating blood;

time detecting means for identifying a point of time corresponding to a predetermined dye density characteristic based on results of measurements of said dye density measuring means;

interval determining means for determining a first and a second interval point for exponential regression curve calculation based on said point of time identified by said time detecting means;

exponential regression curve calculating means for calculating an exponential regression curve for a curve that represents a relationship between said dye density measured by said dye density measuring means and time, wherein said exponential regression curve passes through said first and second interval points as determined by said interval determining means;

initial dye density calculating means for determining a dye density corresponding to an initial dye density by extrapolating said exponential regression curve at least to the point of said time identified by said time detecting means; and

circulating blood volume calculating means for determining said circulating blood volume by dividing an amount of said injected dye by said initial dye density which is determined by said initial dye density calculating means.

2. An apparatus as claimed in claim 1, wherein said time detecting means identifies a point of time where the dye density reaches a mean value.

3. An apparatus as claimed in claim 1, wherein said time detecting means identifies a point of time where the dye density becomes maximal.