Implantable cardiac stimulator with physiologic sensor based on mechanical-electric phase relation

• US 5,999,854 A
• Filed: 04/14/1998
• Issued: 12/07/1999
• Est. Priority Date: 04/14/1998
• Status: Expired due to Term

• Current Assignee: Intermedics Incorporated
• Original Assignee: Intermedics Incorporated
• Inventors: Pergola, Nicholas F., Sterling, Daniel I., Vautravers, Alec, Deno, D. Curtis
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US09/059,860
• Time in Patent Office: 602 Days
• Field of Search: 607/17, 607/18, 607/24
• US Class Current: 607/18
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: G06F 2218/00 Aspects of pattern recognition specially adapted for signal processing

Abstract

A cardiac pacemaker includes circuitry which receives a raw impedance signal from the sensor leads of the pacemaker, derives data from the impedance signal that is descriptive of the impedance signal over an entire (or a large part of the) cardiac cycle, develops first order parameters which define that cycle, and provides these parameters to a microprocessor for control of the pacing signal. These parameters may also be used to determine other information about the functioning of the pacemaker. The present invention may also be applied to the determination of tachycardia of an intrinsically paced heart, as well as other applications.

Claims

1. A method of controlling the pacing rate of a cardiac pacemaker comprising the steps of:

a. receiving a sensor signal waveform from a sensor lead of a pacemaker,

b. deriving data from the sensor signal waveform, the derived data descriptive of the sensor signal waveform over at least most of a cardiac cycle,

c. developing a first order parameter of the sensor signal waveform which defines that cardiac cycle, and

d. providing the first order parameter to a microprocessor for control of a pacing signal of the cardiac pacemaker.

2. The method of claim 1, wherein the sensor is an impedance sensor.

3. The method of claim 1 further comprising the step of digitizing the sensor signal waveform prior to the step of deriving data from the sensor signal waveform.

4. The method of claim 1 wherein the first order parameter of the sensor signal waveform comprises the phase of the sensor signal waveform relative to a pacemaker or electrogram clock.

5. The method of claim 1 wherein the first order parameter of the sensor signal waveform comprises the mean of the sensor signal waveform.

6. The method of claim 1 wherein the first order parameter of the sensor signal waveform comprises the magnitude of the sensor signal waveform.

7. The method of claim 1 wherein the first order parameter of the sensor signal waveform comprises the period of the sensor signal waveform.

8. The method of claim 1 wherein the first order parameter of the sensor signal waveform comprises a time parameter of the sensor signal waveform relative to a pacemaker or electrogram clock.

9. The method of claim 1 wherein the step of developing a first order parameter of the sensor signal waveform comprises developing a composite first order parameter of the sensor signal waveform from a function of the mean, magnitude, phase, period, and time parameters of the sensor signal waveform.

10. The method of claim 1 wherein the step of deriving data from the sensor signal waveform further comprises the step of decomposing the sensor signal waveform into sine and cosine basis function components.

11. The method of claim 1 wherein the step of deriving data from the sensor signal waveform further comprises the step of developing a piecewise constant approximation of the sine and cosine components of the sensor signal waveform.

12. A device for controlling the pacing rate of a cardiac pacemaker comprising:

a. means for receiving a sensor signal waveform from a sensor lead of a pacemaker,

b. means for deriving data from the sensor signal waveform, the derived data descriptive of the sensor signal waveform over at least most of a cardiac cycle,

c. means for developing a first order parameter of the sensor signal waveform which defines that cardiac cycle, and

d. means for providing the first order parameter to a microprocessor for control of a pacing signal of the cardiac pacemaker.

13. The device of claim 12, further comprising means for digitizing the sensor signal waveform.

14. The device of claim 12, further comprising means for decomposing the sensor signal waveform into basis functions, the means for decomposing providing basis functions to the means for developing a first order parameter.

15. The device of claim 12, further comprising means for decomposing the sensor signal waveform into sine and cosine basis functions, the means for decomposing providing basis functions to the means for developing a first order parameter.

16. The device of claim 12, further comprising means for decomposing the sensor signal waveform into sine-square and cosine-square basis functions, the means for decomposing providing basis functions to the means for developing a first order parameter.

17. The device of claim 12, further comprising means for developing a piecewise constant approximation of the sine and cosine components of the sensor signal waveform, the means for developing a piecewise constant approximation providing values to the means for developing a first order parameter.

18. A cardiac stimulation apparatus comprising:

a. a stimulus generator for stimulating a patient'"'"'s heart;

b. a sensor adapted to be coupled to the patient'"'"'s heart for sensing a time varying physiologic characteristic of the heart,

c. a signal injector for impressing a signal, on the heart which develops the signal detected by the sensor;

d. an extractor coupled to the signal injector, the extractor generating a first order parameter of the time varying characteristic of the heart based upon at least most of a cardiac cycle, and

e. a microprocessor to receive the first order parameter and activate a pacing pulse from the stimulus generator based on the first order parameter.

19. A method of controlling the pacing rate of a cardiac pacemaker comprising the steps of:

a. sensing an impedance of a region of a heart with a sensor lead of a pacemaker, resulting in an impedance signal,

b. sampling the impedance signal, resulting in a digitized impedance signal,

c. blanking and padding the digitized impedance signal, resulting in a filtered impedance signal,

d. synchronous averaging the filtered impedance signal, resulting in a synchronous averaged impedance signal,

e. extracting a first order parameter from the synchronous averaged impedance signal,

f. providing the first order parameter to a microprocessor for control of a pacing signal of the cardiac pacemaker.

20. The method of claim 19, wherein the step of extracting a first order parameter includes the steps of:

a. providing the synchronous averaged impedance signal and an event trigger signal to a processor,

b. continuously updating a first set of registers in the processor, the first set of registers storing a set of values representative of the synchronous averaged impedance signal,

c. once each cardiac cycle, outputting the values in the first set of registers to a second set of registers, the second set of registers storing values representative of substantially all of a cardiac cycle, and

d. calculating a first order parameter from the values stored in the second set of registers.

21. The method of claim 20, wherein the first order parameter comprises the phase of the impedance signal.

22. The method of claim 21, further comprising the step of storing in the microprocessor a predetermined phase for comparison with the phase of the impedance signal.

23. The method of claim 22, further comprising the step of comparing the predetermined phase with the phase of the impedance signal and thereby determining the pacing rate of the cardiac pacemaker.

24. The method of claim 22, further comprising the step of comparing the predetermined phase with the phase of the impedance signal and thereby limiting the pacing rate of the cardiac pacemaker.

25. The method of claim 22, further comprising the step of comparing the predetermined phase with the phase of the impedance signal and thereby initiating antitachycardia therapies including burst pacing or defibrillation shocks.

26. The method of claim 22, further comprising the step of comparing the predetermined phase with the phase of the impedance signal while pacing at a rate or timing distinct from the safety pulse or intrinsic rate to assess pacing capture and adjust pacing output pulse amplitude accordingly.

27. A method of controlling the pacing rate of a cardiac pacemaker comprising the steps of:

a. sensing an impedance of a region of a heart with a sensor lead of a pacemaker, resulting in an impedance signal,

b. sampling the impedance signal, resulting in a digitized impedance signal,

c. blanking and padding the digitized impedance signal, resulting in a filtered impedance signal,

d. synchronous averaging the filtered impedance signal, resulting in a synchronous averaged impedance signal,

e. extracting a harmonic of a first order parameter from the synchronous averaged impedance signal,

f. providing the harmonic of the first order parameter to a microprocessor for control of a pacing signal of the cardiac pacemaker.