Iontophoresis method and apparatus

• US 6,001,088 A
• Filed: 08/18/1997
• Issued: 12/14/1999
• Est. Priority Date: 12/02/1994
• Status: Expired due to Term

• Current Assignee: The University of Queensland
• Original Assignee: The University of Queensland
• Inventors: Hirst, Lawrence William, Cross, Sheree Elizabeth, Lai, Pam Muhtze, Roberts, Michael Stephen
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US08/849,280
• Time in Patent Office: 848 Days
• Field of Search: 604/20-21, 604/504, 604/514, 607/135-137, 607/141
• US Class Current: 604/501
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body

Abstract

An iontophoresis method for delivenng an active substance or drug to a target tissue which includes the step of sandwiching the target tissue between a donor electrode and receptor electrode which are each electrically connnected to a power source wherein a current path between the donor electrode and the receptor electrode is maintained at a minimum value to enhance delivery of the active substance to the target tissue.

Claims

1. A method of administration of an active substance to a sensitive target tissue selected from the eye, ear, nose or throat which includes the steps of:

(i) inserting a first electrode into a nasal passage of a subject and applying a second electrode to the subject adjacent the eye or adjacent the ear wherein said first and second electrodes are each electrically connected to a power source and said target tissue is sandwiched between each of said electrodes to achieve a current path which is of minimal electrical resistance and

(ii) delivering said active substance to said target tissue.

2. A method as claimed in claim 1 wherein the first electrode is a donor electrode and the second electrode is a receptor electrode.

3. A method as claimed in claim 2 wherein the donor electrode is a needle electrode.

4. A method as claimed in claim 2 wherein the donor electrode is a probe electrode.

5. A method as claimed in claim 2 wherein the donor electrode is a pad for topical administration.

6. A method as claimed in claim 2, wherein the donor electrode includes an electrode body formed from insulating material, a conductor passing through the electrode body and a compartment for storage of active substance located adjacent an outer end of the electrode body which is provided with access means whereby active substance can be delivered to adjacent tissue.

7. A method as claimed in claim 6 wherein the access means includes apertures in an external wall of the compartment.

8. A method as claimed in claim 6 wherein the access means includes dialysis membrane or porous membrane adjacent to the compartment.

9. A method as claimed in claim 6 wherein the electrode body has an outwardly extending conductor part or needle tip adjacent an outer end of the electrode body.

10. A method as claimed in claim 6 also including an insulating handle.

11. A method as claimed in claim 1 wherein the target tissue is the eye.

12. A method as claimed in claim 1 wherein the target tissue is the ear.

13. A method as claimed in claim 1 wherein the target tissue is the throat.

14. A method as claimed in claim 1 wherein the target tissue is the nose.