Thermal pharmaceutical delivery system

• US 6,001,090 A
• Filed: 02/09/1998
• Issued: 12/14/1999
• Est. Priority Date: 02/09/1998
• Status: Expired due to Fees

• Current Assignee: Douglas Lenhart
• Original Assignee: Douglas Lenhart
• Inventors: Lenhart, Douglas
• Primary Examiner(s): Coggins, Wynn Wood
• Assistant Examiner(s): Blyveis, Deborah
• Application Number:
  US09/020,531
• Time in Patent Office: 673 Days
• Field of Search: 607/3, 604/93, 604/95, 604/20, 604/890.1, 604/48, 604/891.1, 604/113, 604/114
• US Class Current: 604/890.1
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L

Abstract

A preferred thermal pharmaceutical delivery apparatus (10) includes a drug delivery unit (12) including a drug absorbent gel body (16) capable of desorbing a drug upon being heated, a heating element(18) positioned within the gel body (16), and a power receiving antenna (20) coupled with the heating element (18). The drug delivery unit (12) can be implanted subcutaneously in vivo. The apparatus (10) further includes a power unit (14) having a controller (26) coupled with a sending antenna (28) configured for inductively coupling transdermally with the receiving antenna (20) for delivering electrical power thereto in order to heat the element (18) and release the drug from the gel body (16).

Claims

1. A pharmaceutical delivery apparatus comprising:

a pharmaceutical delivery body composed of a semisolid material capable of holding a pharmaceutical and releasing a pharmaceutical upon being heated; and

electrical heating means thermally coupled with said body for receiving electrical power from a source thereof and for selectively electrically heating said body for selectively releasing a pharmaceutical held therein.

3. The apparatus as set forth in claim 1, said body being flexible and form-retaining.

4. The apparatus as set forth in claim 1, said heating means including a heating element thermally coupled with said body.

5. The apparatus as set forth in claim 4, said heating element including a grid of electrical heating wire embedded within said body.

6. The apparatus as set forth in claim 1, said heating means including a heating element thermally coupled with said body and a power receiving antenna electrically coupled with said heating element and configured for receiving electrical power from a source thereof by way of inductive coupling and for delivering power so received to said heating element for heating said element and thereby said body.

2. A pharmaceutical delivery apparatus comprising:

a pharmaceutical delivery body composed of material capable of holding a pharmaceutical and releasing a pharmaceutical upon being heated, and

electrical heating means thermally coupled with said body for receiving electrical power from a source thereof and for selectively electrically heating said body for selectively releasing a pharmaceutical held therein,

said body being composed of material selected from the group consisting of acrylimide gels, polyethylene gels, sylastic gels, polypeptides and collagen.

7. A pharmaceutical delivery apparatus comprising:

a pharmaceutical delivery body composed of material capable of holding a pharmaceutical and releasing a pharmaceutical upon being heated; and

electrical heating means thermally coupled with said body for receiving electrical power from a source thereof and for selectively electrically heating said body for selectively releasing a pharmaceutical held therein,

said heating means including a heating element thermally coupled with said body and a power receiving antenna electrically coupled with said heating element and configured for receiving electrical power from a source thereof by way of inductive coupling and for delivering power so received to said heating element for heating said element and thereby said body,

said heating element including heating wire formed into a grid and embedded within said body.

8. A pharmaceutical delivery apparatus comprising:

a pharmaceutical delivery body composed of material capable of holding a pharmaceutical and releasing a pharmaceutical upon being heated;

electrical heating means thermally coupled with said body for receiving electrical power from a source thereof and for selectively electrically heating said body for selectively releasing a pharmaceutical held therein,

said heating means including a heating element thermally coupled with said body and a power receiving antenna electrically coupled with said heating element and configured for receiving electrical power from a source thereof by way of inductive coupling and for delivering power so received to said heating element for heating said element and thereby said body; and

a power unit including a power controller coupled with a power sending antenna configured for inductively coupling with said receiving antenna for delivering electrical power thereto.

9. The apparatus as set forth in claim 8, said body, pharmaceutical and heating means being implantable subcutaneously in vivo, said antennas being configured for inductively coupling transdermally.

10. A pharmaceutical delivery apparatus comprising:

a pharmaceutical delivery body composed of material capable of holding a pharmaceutical and releasing a pharmaceutical upon being heated; and

electrical heating means thermally coupled with said body for receiving electrical power from a source thereof and for selectively electrically heating said body for selectively releasing a pharmaceutical held therein,

said delivery body including a pharmaceutical held therein and being flexible, form-retaining, and composed of material selected from the group consisting of acrylimide gels, polyethylene gels, sylastic gels, polypeptides and collagen,

said heating means including heating wire formed into a grid and embedded within said delivery body and thermally coupled therewith, and including a receiving antenna electrically coupled with said heating element and configured for receiving electrical power from a source thereof by way of inductive coupling and for delivering power so received to said heating element for heating said element and thereby said body,

said apparatus further including a power unit including a controller coupled with a sending antenna configured for inductively coupling with said receiving antenna for delivering electrical power thereto,

said body, pharmaceutical and heating means being implantable subcutaneously in vivo, said antennas being configured for inductively coupling transdermally.