Use of starch for transdermal applications

• US 6,001,385 A
• Filed: 06/30/1997
• Issued: 12/14/1999
• Est. Priority Date: 09/21/1994
• Status: Expired due to Term

• Current Assignee: Injectile Technologies GmbH
• Original Assignee: Giisbertus G. P. Van De Wijdeven
• Inventors: Van De Wijdeven, Giisbertus G. P.
• Primary Examiner(s): BROUILLETTE, D GABRIELLE
• Application Number:
  US08/809,096
• Time in Patent Office: 897 Days
• Field of Search: 424/422, 424/426, 424/488
• US Class Current: 424/422
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/2059 Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Abstract

The invention relates to the use of substantially fully destructurized starch for transdermal applications in humans and animals, in particular the use of solid particles such as implants. The invention further relates to the implants manufactured of substantially fully destructurized starch, in addition to methods for manufacturing the implants.

Claims

1. A transdermal implant comprising substantially fully destructurized starch wherein the implant is a bullet.

2. The transdermal implant as claimed in claim 1 wherein the is hollow.

3. The transdermal implant as claimed in claim 2 wherein the bullet further comprises a filling comprising at least one therapeutic, diagnostic or prophylactic compound and optionally a suitable diluent.

4. The transdermal implant as claimed in claim 1 wherein the bullet is solid.

5. The transdermal implant as claimed in claim 4 wherein the bullet comprises a mixture of substantially destructurized starch and at least one therapeutic, diagnostic or prophylactic compound.

6. The transdermal implant as claimed in claim 1 wherein the implant comprises a tip such that manual pushing of the implant through skin is possible.

7. The transdermal implant as claimed in claim 6 wherein the radius r of the tip of the implant is smaller than 0.5 mm, and the angle which the tangent lines of the side surfaces of the tip form with each other is not smaller than 30°

and up to a maximum of 120°

in order to enable pushing of the implant through skin of 0.1 to 1.5 mm thickness.

8. The transdermal implant as claimed in claim 7 wherein the radius r of the tip of the implant is smaller than 0.25 mm and the angle which the tangent lines of the side surfaces of the tip form with each other is between 45°

and 60°

.

9. The transdermal implant as claimed in claim 8, wherein the radius r of the tip of the implant is between 0.03 and 0.1 mm.

10. The transdermal implant as claimed in claim 8 wherein the filling comprises an inoculant.

11. The transdermal implant as claimed in claim 2 wherein the bullet contains an identification chip.

12. The transdermal implant as claimed in claim 3 wherein the filling comprises a therapeutic or prophylactic composition.

13. A method of administering an implant transdermally comprising introducing the transdermal implant of claim 1 under the skin.

14. The method of claim 13 wherein the transdermal implant comprises substantially fully destructurized starch and at least one therapeutic, diagnostic or prophylactic compound, optionally in combination with a suitable diluent.

15. A method for filling a hollow bullet transdermal implant with a therapeutic, diagnostic or prophylactic compound comprising freezing the implant, cooling a watery solution containing the therapeutic, diagnostic or prophylactic compound, pouring the watery solution into the implant, freezing the filled implant, and freeze drying the filled and frozen implant.