Process for producing solid drug forms having at least two phases
First Claim
1. A process for producing solid combination drug forms which have at least a first phase and a second phase, wherein at least the first phase contains a pharmacologically acceptable polymeric binder and at least one of the first and the second phase contains a pharmaceutically active ingredient, comprising(i) providing a plastic melt of a polymeric binder (binder A) with or without at least one active ingredient, which forms the first phase,(ii) molding the plastic melt to the drug form, and(iii) incorporating in the plastic melt during the molding step at least one solid product which may contain at least one active ingredient which solid product forms the second phase.
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Abstract
A process for producing solid combination tablets which have at least two phases comprises molding a melt of a polymeric binder with or without at least one active ingredient, there being at least one solid product, which may contain an active ingredient incorporated into the still plastic composition during the molding step.
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Citations
16 Claims
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1. A process for producing solid combination drug forms which have at least a first phase and a second phase, wherein at least the first phase contains a pharmacologically acceptable polymeric binder and at least one of the first and the second phase contains a pharmaceutically active ingredient, comprising
(i) providing a plastic melt of a polymeric binder (binder A) with or without at least one active ingredient, which forms the first phase, (ii) molding the plastic melt to the drug form, and (iii) incorporating in the plastic melt during the molding step at least one solid product which may contain at least one active ingredient which solid product forms the second phase.
- 11. A solid combination drug form which has at least two phases which comprises a first phase of at least one pharmacologically acceptable polymeric binder (binder A) in the form of a solidified melt optionally containing, at least one pharmaceutically active ingredient and into which a solid product which contains at least one active ingredient is taken up as second phase.
Specification