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Modified nucleic acid amplification primers

  • US 6,001,611 A
  • Filed: 03/16/1998
  • Issued: 12/14/1999
  • Est. Priority Date: 03/20/1997
  • Status: Expired due to Term
First Claim
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1. An oligonucleotide primer for the amplification of a nucleic acid sequence, said primer having the general structure:

  • ##STR10## wherein S1 represents a first sequence of nucleotides between about 5 and about 50 nucleotides in length;

    wherein S2 represents a second sequence between one and three nucleotides in length;

    wherein N represents a nucleotide that contains a purine or pyrimidine base that contains an exocyclic amine;

    wherein R represents a modifier group, wherein R is covalently bound to the nitrogen atom of the exocyclic amine, and wherein R has the structure;

    ##STR11## wherein R1 and R2 represent independently hydrogen, a C1 -C10 alkyl group, an alkoxy group, a phenyl group, a phenoxy group, a substituted phenyl group, a napthyl group, or a substituted napthyl group.

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