Optical sensors for the detection of nitric oxide
First Claim
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1. An optical fiber comprising a fiber tip, said tip comprising an immobilized nitric oxide-binding compound selected from the group consisting of heme-binding proteins, porphyrin group-containing proteins, heme group-containing proteins, dye-labeled porphyrin group-containing proteins, dye-labeled heme group-containing proteins, and fragments thereof.
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Abstract
Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or fragments thereof) with selective binding are immobilized on metal particles. The proteins may be dye-labeled for increased sensitivity.
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Citations
33 Claims
- 1. An optical fiber comprising a fiber tip, said tip comprising an immobilized nitric oxide-binding compound selected from the group consisting of heme-binding proteins, porphyrin group-containing proteins, heme group-containing proteins, dye-labeled porphyrin group-containing proteins, dye-labeled heme group-containing proteins, and fragments thereof.
- 17. An optical fiber comprising a fiber tip, said tip comprising a metal monolayer and a protein or fragment thereof immobilized on said metal layer.
Specification