Catheters

• US 6,004,295 A
• Filed: 06/26/1998
• Issued: 12/21/1999
• Est. Priority Date: 06/26/1997
• Status: Expired due to Fees

• Current Assignee: AN-Go-Gen Inc.
• Original Assignee: AN-Go-Gen Inc.
• Inventors: Langer, Anatoly, Stewart, Duncan John
• Primary Examiner(s): Stright, Jr., Ronald K.
• Assistant Examiner(s): BIANCO, PATRICIA
• Application Number:
  US09/104,991
• Time in Patent Office: 543 Days
• Field of Search: 604/115, 604/117, 604/118, 604/121, 604/125, 604/132, 604/158, 604/162, 604/164, 604/181, 604/185, 604/187, 604/214, 604/216, 604/217, 604/218, 604/264, 604/523, 604/528, 600/432, 600/433, 600/434, 600/435
• US Class Current: 604/164.01
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2017/22077 with a part piercing the tissue A61B2017/22044 takes precedence
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/0089 Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
• CPC Class Codes: A61M 2210/125 Heart
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/0084 being one or more injection needles

Abstract

A catheter assembly especially adapted for injecting therapeutic liquids such as DNA solutions to a patient'"'"'s myocardium comprises an elongated guiding catheter for insertion through a patient'"'"'s artery to the vicinity of the myocardium, a reservoir for therapeutic liquid at the distal end of the guiding catheter, one or more injection needles protruding from the distal end of the guiding catheter and in fluid communication with the reservoir, the extent of needle protrusion being appropriate for penetration of but not passage through the myocardial wall, and an operating device for delivering a predetermined quantity of therapeutic liquid from the reservoir through the needles.

Claims

1. A catheter assembly comprising:

an elongated flexible biocompatible tube constituting a guiding catheter and having a proximal end portion and a distal end portion;

a reservoir adapted to contain treatment fluid and disposed in the distal end portion of the guiding catheter;

a guide wire extending through the reservoir to protrude beyond the distal end of the guiding catheter;

at least one needle adapted to protrude from the reservoir and beyond the distal end of the guiding catheter to a predetermined extent;

said at least one needle having a bore with an inlet communicating with the reservoir and an outlet disposed distally beyond the distal end of the guiding catheter;

operating means for delivering a predetermined quantity of treatment fluid from the reservoir through the needle outlet;

and an operating wire extending axially through the guiding catheter from the proximal end thereof to the reservoir, said operating wire connecting the reservoir to the operating means.

2. A catheter assembly of claim 1 wherein said operating means is operable to change the volume of said reservoir so as to expel the contents thereof through said at least one needle in predetermined quantity.

3. The catheter assembly of claim 2 wherein said reservoir comprises a cartridge having a distal end wall carrying said at least one needle and a proximal end wall constituted by a movable plunger connected to said operating means.

4. The catheter assembly of claim 3 wherein said cartridge is movable axially with respect to the guiding catheter in response to operation of the operating means.

5. The catheter assembly of claim 2 including an injection catheter disposed within and axially movable relative to said guiding catheter in response to operation of said operating means, said injection catheter incorporating the reservoir and means for changing the volume of the reservoir.

6. The catheter assembly of claim 5 wherein the reservoir comprises a generally cylindrical chamber having a distal end wall carrying said at least one injection needle, and a proximal end wall movable axially within the chamber in response to operation of the operating means to constitute the means for changing the volume of the reservoir.

7. The catheter assembly of claim 2 including an injection catheter disposed within the guiding catheter, said injection catheter having the reservoir formed therein and defined by deformable side walls, the operating means being operable to compress the reservoir to expel liquid contents thereof through the injection needle.

8. The catheter assembly of claim 7 wherein the operating means comprises a source of fluid pressure applicable to the exterior of the deformable side walls of the reservoir to effect compression thereof.

9. The catheter assembly of claim 1 wherein said operating wire is tubular.

10. The catheter assembly of claim 9 wherein the guide wire extends axially through the tubular operating wire.

11. The catheter assembly of claim 1 including an injection catheter disposed within the guiding catheter, said injection catheter having the reservoir formed therein as a narrow, axially extending lumen, connected at its proximal end to an operating means in the form of a syringe of liquid operable to apply liquid pressure to expel liquid from the lumen through the injection needle.

12. The catheter assembly of claim 1 wherein the guide wire extends through the needle.

13. A catheter assembly comprising:

an elongated flexible biocompatible tube constituting a guiding catheter and having a proximal end portion and a distal end portion;

an injection catheter disposed within the guiding catheter;

a reservoir adapted to contain treatment fluid and disposed within the injection catheter and at the distal end portion of the guiding catheter, said reservoir being defined by deformable side walls;

at least one needle adapted to protrude from the reservoir and beyond the distal end of the guiding catheter to a predetermined extent;

said at least one needle having a bore with an inlet communicating with the reservoir and an outlet disposed distally beyond the distal end of the guiding catheter;

operating means for delivering a predetermined quantity of treatment fluid from the reservoir through the needle outlet, said operating means comprising a source of fluid pressure applicable to the exterior of the deformable side walls of the reservoir to effect compression thereof for delivering said predetermined quantity of treatment fluid.