Method and apparatus for controlled environment electrotransport

• US 6,004,309 A
• Filed: 04/18/1997
• Issued: 12/21/1999
• Est. Priority Date: 03/30/1990
• Status: Expired due to Fees

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Phipps, Joseph B.
• Primary Examiner(s): Coggins, Wynn Wood
• Assistant Examiner(s): Sadula, Jennifer R.
• Application Number:
  US08/843,561
• Time in Patent Office: 977 Days
• Field of Search: 604/20, 604/49, 604/21, 128/898
• US Class Current: 604/501
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

Methods for conducting operation of an electrode arrangement are described. The methods generally concern use of an electrode reservoir containing both a first electrode and a secondary electrode. A system for practicing the methods is also provided.

Claims

1. A method of operating an electrode system, the method including steps of:

(a) providing a primary electrode system including;

(i) a first reservoir including at least --one--first reservoir electrode and an electrolyte; and

(ii) a second reservoir including at least --one--second reservoir electrode and an electrolyte;

the second reservoir being spaced from the first reservoir;

(b) providing a secondary electrode system including;

(i) a secondary electrode, located within the first reservoir and isolated from direct electrical contact with the first reservoir electrode; and

(ii) a companion electrode;

(c) selectively operating the primary electrode system to provide electromotive movement of a species between a reservoir and a subject; and

(d) selectively operating the secondary electrode system to generate a potential between the secondary electrode and the companion electrode, wherein the companion electrode is the at least one second reservoir electrode, such that an effect of electrochemical reactions involving the secondary electrode system on contents of the reservoir is different from that of the primary electrode system.

2. A method according to claim 1 wherein:

(a) the step of selectively operating the secondary electrode system comprises generating a potential between the secondary electrode and the companion electrode in a manner lowering a presence of a material in a reservoir.

3. A method according to claim 1 wherein:

(a) the step of directing electrical current between a first reservoir electrode and the second reservoir electrode is conducted as a step of a diagnostic procedure.

4. A method of operating an electrode system;

the method including the steps of;

(A) placing an electrode system in electrically conductive contact with a skin surface of patient;

the electrode system including;

(a) a primary electrode system including;

(i) a first reservoir including at least --one--first reservoir electrode and an electrolyte; and

(ii) a second reservoir including at least --one--second reservoir electrode and an electrolyte;

the second reservoir being spaced from the first reservoir; and

(b) a secondary electrode system including;

(i) a secondary electrode, located within the first reservoir and isolated from direct electrical contact with the at least one first reservoir electrode; and

(ii) a companion electrode;

(B) directing an electrical current between the at least one first reservoir electrode and the at least one second reservoir electrode, through the patient; and

(C) operating the secondary electrode system by generating a potential between the secondary electrode and the companion electrode, wherein the companion electrode is a second reservoir electrode, to lower a presence of a selected material within a reservoir.

5. A method according to claim 4 wherein:

(a) the step of operating the secondary electrode system is conducted after the step of directing an electrical current between a first reservoir electrode and a second reservoir electrode has been suspended.

6. A method according to claim 4 wherein:

(a) the secondary electrode system is operated with the secondary electrode as an anode and a second reservoir electrode as a cathode.

7. A method according to claim 4 wherein:

(a) the step of operating the secondary electrode system comprises a step of applying a sufficient potential to oxidize the selected material at the secondary electrode.

8. A method according to claim 4 wherein:

(a) the secondary electrode is a platinum electrode.

9. A method according to claim 4 wherein:

(a) the step of operating the secondary electrode system comprises a step of generating hydronium ions within the first reservoir.

10. A method according to claim 4 wherein:

(a) during at least a portion of the step of directing an electrical current between the at least one first reservoir electrode and the at least one second reservoir electrode, the at least one first reservoir electrode is operated as a cathode.

11. A method according to claim 4 wherein:

(a) the step of operating the secondary electrode system is conducted to lower a presence of an active drug by converting it to an inactive form.

12. A method according to claim 4 wherein:

(a) the step of directing an electrical current between the first at least one reservoir electrode and the at least one second reservoir electrode includes conducting electro-osmosis.

13. A method according to claim 12 wherein:

(a) the electro-osmosis includes transferring an uncharged material from the first reservoir to the patient.

14. A method according to claim 4 wherein:

(a) the step of directing electrical current between the at least one first electrode and the at least one second reservoir electrode is conducted as a step of a diagnostic procedure.

15. A method of conducting operation of an electrode system;

the method including the steps of;

(A) placing an electrode system in electrically conductive contact with a skin surface of patient;

the electrode system including;

(a) a primary electrode system including;

(i) a first reservoir including at least --one--first reservoir electrode and an electrolyte; and

(ii) a second reservoir including at least --one--second reservoir electrode and an electrolyte;

the second reservoir being spaced from the first reservoir; and

(b) a secondary electrode system including;

(i) a secondary electrode, located within the first reservoir and isolated from direct electrical contact with the at least one first reservoir electrode; and

(ii) a companion electrode;

(B) directing an electrical current between the at least one first reservoir electrode and the at least one second reservoir electrode, through the patient; and

(C) operating the secondary electrode system to generate a potential between the secondary electrode and the companion electrode to lower a presence of a selected material within the at least one first reservoir, wherein the companion electrode is the at least one first reservoir electrode and the step of operating the secondary electrode system is conducted after the step of directing an electrical current between the at least one first reservoir electrode and the at least one second reservoir has been completed.

16. A method according to claim 15 wherein:

(a) the secondary electrode is operated as an anode and the at least one first reservoir electrode is operated as a cathode.

17. A method according to claim 15 wherein:

(a) the secondary electrode is operated as an inert electrode and the first electrode is operated as a sacrificial electrode.

18. A method according to claim 15 wherein:

(a) the at least one first reservoir electrode is an Ag/AgCl electrode.

19. A method according to claim 15 wherein:

(a) the step of operating the secondary electrode system is conducted after the electrode system is separated from contact with the patient.

20. A method according to claim 15 wherein:

(a) the step of directing electrical current between the at least one first reservoir electrode and at least one the second reservoir electrode is conducted as a step of a diagnostic procedure.