Intralumenal drug eluting prosthesis
First Claim
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1. A device for local intralumenal administration of drugs comprising:
- (a) a body including a plurality of support elements forming a open-ended, radially expandable, self-supporting tubular structure having an interior surface and an exterior surface, the tubular structure including as support elements a plurality of helical elements, each of which is wound in a helix configuration along a center line of the tubular body as a common axis, said helical elements wound in opposing helical directions such that the tubular body is variable in radial diameter under axial movement of opposite ends of the body relative to each other;
(b) a flexible, polymeric filament attached to the support elements of the body, at least a portion of the filament exposed at an exterior surface of the tubular body; and
(c) a drug compounded into the polymeric filament such that the drug is delivered to the body lumen when the tubular body is radially expanded into contact with the portion of the body lumen to be treated.
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Abstract
A prosthesis for insertion into a lumen to limit restenosis of the lumen. The prosthesis carries restenosis-limiting drugs which elute after the device is positioned in the lumen.
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Citations
8 Claims
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1. A device for local intralumenal administration of drugs comprising:
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(a) a body including a plurality of support elements forming a open-ended, radially expandable, self-supporting tubular structure having an interior surface and an exterior surface, the tubular structure including as support elements a plurality of helical elements, each of which is wound in a helix configuration along a center line of the tubular body as a common axis, said helical elements wound in opposing helical directions such that the tubular body is variable in radial diameter under axial movement of opposite ends of the body relative to each other; (b) a flexible, polymeric filament attached to the support elements of the body, at least a portion of the filament exposed at an exterior surface of the tubular body; and (c) a drug compounded into the polymeric filament such that the drug is delivered to the body lumen when the tubular body is radially expanded into contact with the portion of the body lumen to be treated. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A device for local intralumenal administration of drugs comprising:
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(a) a body including a plurality of support elements forming a open-ended, radially expandable, self-supporting tubular structure having an interior surface and an exterior surface, the tubular structure including as support elements a plurality of helical elements, each of which is wound in a helix configuration along a center line of the tubular body as a common axis, said helical elements wound in opposing helical directions such that the tubular body is variable in radial diameter under axial movement of opposite ends of the body relative to each other; (b) a first flexible, polymeric filament attached to the support elements of the body, at least a portion of the filament exposed at an exterior surface of the tubular body; and (c) a drug compounded into the first polymeric filament such that the drug is delivered to the body lumen when the tubular body is radially expanded into contact with the portion of the body lumen to be treated, wherein the first polymeric filament includes a drug selected from the group consisting of anticoagulant drugs and antiplatelet drugs and wherein the device also comprises a second polymeric filament having a drug compounded therein selected from the group consisting of antiinflammatory drugs and antireplicate drugs such that the drug in the first polymeric filament is delivered to the body lumen more rapidly than from the second polymeric filament.
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Specification