Cardiac output monitor using fuzzy logic blood pressure analysis

• US 6,007,491 A
• Filed: 02/06/1998
• Issued: 12/28/1999
• Est. Priority Date: 02/06/1998
• Status: Expired due to Term

• Current Assignee: Southwest Research Institute
• Original Assignee: Southwest Research Institute
• Inventors: Ling, Jian, Winter, Dean Carl, Robey, Brian L.
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): ASTORINO, MICHAEL C
• Application Number:
  US09/020,177
• Time in Patent Office: 690 Days
• Field of Search: 600/481-503, 600/529-538, 600/300, 128/920-925
• US Class Current: 600/481
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics

Abstract

A method of monitoring cardiac output. The method uses a blood pressure waveform as input. The waveform is digitized and various blood pressure features are extracted. The features are used as inputs to a fuzzy logic model, where each input is fuzzified by determining its degree of confidence as a member of one or more fuzzy membership regions. A rule base is applied to the defuzzified inputs to obtain a fuzzy stroke volume index. This output is defuzzied and used to calculate cardiac output.

Claims

1. A cardiac output monitor, comprising:

an analog to digital converter for receiving an arterial blood pressure waveform and converting said waveform to blood pressure waveform data;

a digital signal processor for processing said blood pressure waveform data so as to obtain blood pressure feature data; and

a fuzzy logic processor programmed to perform a fuzzy logic process on said feature data, using a set of fuzzy logic rules, thereby obtaining stroke volume data.

2. The monitor of claim 1, wherein said blood pressure waveform is an aortic blood pressure waveform.

3. The monitor of claim 1, wherein said blood pressure waveform is a radial blood pressure waveform.

4. The monitor of claim 1, wherein said blood pressure waveform is a femoral blood pressure waveform.

5. The monitor of claim 1, wherein said digital signal processor is programmed to extract a systolic area and a vascular reference index feature.

6. The monitor of claim 5, wherein said digital signal processor is programmed to compensate said systolic area feature by heart rate and mean arterial pressure.

7. The monitor of claim 1, wherein said rules relate a systolic area feature and a vascular resistance index feature to said stroke volume index.

8. The monitor of claim 1, wherein said digital signal processor is programmed to calculate a heart rate value from said blood pressure waveform data.

9. The monitor of claim 1, wherein said digital signal processor is programmed to calculate a respiration period, and a heartbeat period, and to average said features for a number of heartbeat periods within a respiration period.

10. A method of monitoring cardiac output, comprising the steps of:

acquiring arterial blood pressure waveform data;

processing said blood pressure waveform data so as to obtain blood pressure feature data; and

applying a fuzzy logic process, using fuzzy logic rules, to said feature data, thereby obtaining stroke volume data.

11. The method of claim 10, wherein said blood pressure waveform is an aortic blood pressure waveform.

12. The method of claim 10, wherein said blood pressure waveform is a radial blood pressure waveform.

13. The method of claim 10, wherein said blood pressure waveform is a femoral blood pressure waveform.

14. The method of claim 10, wherein said feature data comprises a systolic area feature and a vascular reference index feature.

15. The method of claim 14, wherein said systolic area feature is compensated by heart rate and mean arterial pressure.

16. The monitor of claim 10, wherein said rules relate a systolic area feature and a vascular resistance index feature to said stroke volume index.

17. The monitor of claim 10, further comprising the step of processing said blood pressure waveform data to extract a heart rate value.

18. The monitor of claim 10, further comprising the steps of using said blood pressure waveform data to calculate a respiration period and a heartbeat period, and of averaging said features for a number of heartbeat periods within a respiration period.

19. A method of monitoring cardiac output, comprising the steps of:

acquiring arterial blood pressure waveform data;

processing said blood pressure waveform data so as to obtain blood pressure feature data, said blood pressure feature data comprising at least a measure of systolic area and a measure of vascular resistance; and

applying a set of fuzzy logic rules to said feature data, thereby obtaining stroke volume data.

20. The method of claim 19, wherein said feature data is calculated such that such stroke volume data is an index value.