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Integrated microfluidic devices

  • US 6,007,690 A
  • Filed: 07/30/1997
  • Issued: 12/28/1999
  • Est. Priority Date: 07/30/1996
  • Status: Expired due to Term
First Claim
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1. An integrated microfluidic device comprising microchannels formed in a generally planar substrate, said device comprising:

  • an enrichment microchannel comprising an enrichment channel portion containing an enrichment medium, said enrichment channel portion having a sample inlet, a discharge outlet, an elution inlet, and an enriched fraction fluid outlet;

    a main electrophoretic microchannel enclosing a main electrophoretic flowpath, said main electrophoretic microchannel being connected in fluid-conducting relationship to said enriched fraction fluid outlet, and said main electrophoretic microchannel comprising a detection region; and

    means for moving a sample into said enrichment channel portion by way of said sample inlet and out from said enrichment channel portion by way of said discharge outlet, whereby at least a fraction of a component of interest in the sample is retained by said enrichment medium;

    means for moving at least a portion of the fraction of the component of interest out from said enrichment channel portion by way of said enriched fraction outlet and into said main electrophoretic microchannel, wherein said means for moving the fraction of the component of interest out from said enrichment channel portion and into said main electrophoretic microchannel comprises a first electrode located in said enrichment channel at a point upstream from said elution inlet and a second electrode located downstream from said detection region.

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