Crosslinkable macromers bearing initiator groups
First Claim
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1. A crosslinkable macromer system comprising one or more polymers providing pendent polymerizable and pendent initiator groups wherein the system is adapted to be polymerized in order to form a matrix suitable for iin vivo application, and wherein either:
- (a) the polymerizable groups and initiator group(s) are pendent on different polymers and the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of benzophenone, thioxanthones, and benzoin ethers;
visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
thermally activatable molecules selected from the group consisting of 4,4'"'"' azobis(4-cyanopentanoic) acid, and 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride, and benzoyl peroxide; and
the pendent polymerizable groups are selected from the group consisting of vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups, or(b) the polymerizable groups and the initiator group(s) are pendent on the same polymer and the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of thioxanthones, and benzoin ethers;
visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
thermally activatable molecules selected from the group consisting of 4,4'"'"' azobis(4-cyanopentanoic) acid, and 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride, and benzoyl peroxide; and
the pendent polymerizable groups are selected from the group consisting of vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups;
or(c) the polymerizable groups and the initiator group(s) are pendent on the same polymer and the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of benzophenone, thioxanthones, and benzoin ethers;
visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythirosin; and
thermally activatable molecules selected from the group consisting of 4,4'"'"' azobis(4-cyanopentanoic) acid, and 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride, and benzoyl peroxide; and
the pendent polymerizable groups are selected from the group consisting of acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups.
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Abstract
A crosslinkable macromer system that includes two or more polymer-pendent polymerizable groups and one or more polymer-pendent initiator groups. The polymerizable groups and the initiator group(s) can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility.
238 Citations
44 Claims
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1. A crosslinkable macromer system comprising one or more polymers providing pendent polymerizable and pendent initiator groups wherein the system is adapted to be polymerized in order to form a matrix suitable for iin vivo application, and wherein either:
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(a) the polymerizable groups and initiator group(s) are pendent on different polymers and the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of benzophenone, thioxanthones, and benzoin ethers;
visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
thermally activatable molecules selected from the group consisting of 4,4'"'"' azobis(4-cyanopentanoic) acid, and 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride, and benzoyl peroxide; and
the pendent polymerizable groups are selected from the group consisting of vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups, or(b) the polymerizable groups and the initiator group(s) are pendent on the same polymer and the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of thioxanthones, and benzoin ethers;
visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
thermally activatable molecules selected from the group consisting of 4,4'"'"' azobis(4-cyanopentanoic) acid, and 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride, and benzoyl peroxide; and
the pendent polymerizable groups are selected from the group consisting of vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups;
or(c) the polymerizable groups and the initiator group(s) are pendent on the same polymer and the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of benzophenone, thioxanthones, and benzoin ethers;
visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythirosin; and
thermally activatable molecules selected from the group consisting of 4,4'"'"' azobis(4-cyanopentanoic) acid, and 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride, and benzoyl peroxide; and
the pendent polymerizable groups are selected from the group consisting of acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A crosslinkable macromer system comprising one or more polymers providing pendent polymerizable and pendent initiator groups wherein the system is adapted to be polymerized in order to form a matrix suitable for in vivo application, and wherein the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of benzophenone, thioxanthones, and benzoin ethers;
- visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
thermally activatable molecules selected from the group consisting of 4,4'"'"' azobis(4-cyanopentanoic) acid, and 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride, and benzoyl peroxide; and
the pendent polymerizable groups are selected from the group consisting of vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups, wherein the system comprises polymers bearing both initiator groups and polymerizable groups in combination with polymers providing only pendent polymerizable groups.
- visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
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39. A crosslinkable macromer system comprising one or more polymers providing pendent polymerizable and pendent initiator groups wherein the system is adapted to be polymerized in order to form a matrix suitable for in vivo application, and wherein the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of benzophenone, thioxanthones, and benzoin ethers;
- visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
thermally activatable molecules selected from the group consisting of 4,4'"'"' azobis(4-cyanopentanoic) acid, and 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride, and benzoyl peroxide; and
the pendent polymerizable groups are selected from the group consisting of vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups, wherein the groups are pendent upon biodegradable polymers adapted to form hydrogel matrices. - View Dependent Claims (40, 41)
- visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
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42. A crosslinkable macromer system comprising one or more polymers providing pendent polymerizable and pendent initiator groups wherein the system is adapted to be polymerized in order to form a matrix suitable for in vivo application, and wherein the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of benzophenone, thioxanthones, and benzoin ethers;
- visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
thermally activatable molecules selected from the group consisting of 4,4'"'"' azobis(4-cyanopentanoic) acid, and 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride, and benzoyl peroxide; and
the pendent polymerizable groups are selected from the group consisting of vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups, wherein the polymer comprises a synthetic polymer prepared via condensation polymerization of one or more monomers. - View Dependent Claims (43)
- visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
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44. A crosslinkable macromer system comprising one or more polymers providing pendent polymerizable and pendent initiator groups wherein the system is adapted to be polymerized in order to form a matrix suitable for in vivo application, and wherein the initiator groups are independently selected from the group consisting of long wave ultraviolet activatable molecules selected from the group consisting of benzophenone, thioxanthones, and benzoin ethers;
- visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
thermally activatable molecules selected from the group consisting of 4,4'"'"' azobis(4-cyanopentanoic) acid, and 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride, and benzoyl peroxide; and
the pendent polymerizable groups are selected from the group consisting of vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups, wherein the polymers further comprise pendent reactive groups or affinity groups, and wherein the reactive groups or affinity groups are adapted to bind to target groups on a surface of interest.
- visible light activatable molecules selected from the group consisting of ethyl eosin, eosin Y, rose bengal, camphorquinone and erythrosin; and
Specification