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Transdermal matrix system

  • US 6,007,835 A
  • Filed: 03/26/1998
  • Issued: 12/28/1999
  • Est. Priority Date: 09/27/1995
  • Status: Expired due to Fees
First Claim
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1. A transdermal matrix system for the percutaneous administration of at least one hormone, said matrix system having a support and an adhesive matrix wherein said matrix comprises:

  • (a) 20 to 50 parts by weight of a poly(styrene-isoprene-styrene) triblock (SIS) copolymer,(b) 30 to 60 parts by weight of a tackifying resin,(c) 4 to 25 parts by weight of propylene glycol laurate,(d) 2 to 10 parts by weight of an N-alkyl-2-pyrrolidone compound in which the alkyl group is a C4 --C15 group,(e) 0.1 to 2 parts by weight of a stabilizing agent,(f) 0.1 to 12 parts by weight of at least one hormone selected from the group consisting of oestrogen compounds and progestogen compounds, and(g) 1 to 12 parts by weight of a vinyl acetate/N-vinyl-2-pyrrolidone (VA/VP) copolymer.

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