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Compositions and methods for treating bone deficit conditions

  • US 6,008,208 A
  • Filed: 06/19/1997
  • Issued: 12/28/1999
  • Est. Priority Date: 10/23/1995
  • Status: Expired due to Term
First Claim
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1. A method to treat a condition in a vertebrate animal characterized by a deficiency in, or need for, bone growth replacement and/or an undesirable level of bone resorption, which method comprises administering to a vertebrate subject in need of such treatment an effective amount of a compound of the formula:

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    space="preserve" listing-type="equation">Ar.sup.1 --L--Ar.sup.2wherein Ar1 has the formula;

    ##STR42## wherein Ra is a non-interfering substituent;

    m is an integer of 0-4;

    each dotted line represents an optional π

    -bond;

    each Z is independently N, NR, O, S, CR or CR2, where each R is independently H or alkyl (1-6C);

    X is O, S, SO or SO2 ;

    L is a flexible linker; and

    Ar2 is a substituted or unsubstituted 6-membered aromatic ring.

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