Blood parameter measurement device

• US 6,009,339 A
• Filed: 02/27/1997
• Issued: 12/28/1999
• Est. Priority Date: 02/27/1997
• Status: Expired due to Term

• Current Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Original Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Inventors: Bentsen, James G., Abul-Haj, N. Alan, Hacker, Thomas G., Abul-Haj, Roxanne E., Lee, Gary W., Heinemann, Stanley O.
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US08/810,955
• Time in Patent Office: 1,034 Days
• Field of Search: 600/310, 600/317, 600/322, 356/35, 356/41, 356/244, 356/246, 356/410, 356/411
• US Class Current: 600/322
• CPC Class Codes: A61B 5/14557 specially adapted to extracorporeal circuits
• CPC Class Codes: G01N 21/05 Flow-through cuvettes G01N21/09 takes precedence; handling fluid samples G01N1/10

Abstract

A blood parameter measurement device especially useful for surgical procedures includes a compact housing with a light source, light detector and signal converter contained within the housing. In use, the device is releasably coupled to a cassette that can be either used as an in-line cell in series with a cardiopulmonary by-pass circuit, or in another passageway that shunts the cardiopulmonary by-pass circuit. Preferably, the housing of the device has a longitudinal axis that extends in a direction generally parallel to the direction of blood flowing through the cassette.

Claims

1. A system for measuring one or more parameters of blood comprising:

a cassette having a chamber for receiving a quantity of blood, said cassette including at least one optical sensor; and

a device having a housing with a coupling for releasably connecting to said cassette, said device including at least one light source fixed to said housing for directing light toward said at least one sensor, at least one light detector fixed to said housing for detecting light from said at least one sensor, and at least one signal converter fixed to said housing and connected to said at least one light detector, said at least one signal converter providing a digital output signal that varies in response to the quantity of light detected by said at least one light detector.

2. The system of claim 1 wherein said at least one light source comprises at least one solid state light source.

3. The system of claim 1 wherein said at least one light detector is a solid state light detector.

4. The system of claim 1 wherein said at least one solid state light source is a gallium nitride light emitting diode.

5. The system of claim 4 wherein said at least one sensor is a fluorescing sensor.

6. The system of claim 4 wherein said at least one sensor is a coumarocyrptand-based ion sensor.

7. The system of claim 4 wherein said at least one sensor is a polyaromatic hydrocarbon-based oxygen sensor.

8. The system of claim 4 wherein said at least one light detector is a solid state light detector.

9. The system of claim 1 wherein said device includes a first plurality of optical fibers and a second plurality of optical fibers, said first plurality of optical fiber optically coupled to said at least one light source and extending toward said coupling for directing light toward said at least one sensor, said first plurality of optical fibers having a certain cross-sectional area adjacent said coupling, said second plurality of optical fibers optically coupled to said at least one light detector and extending toward said coupling for receiving light from said at least one sensor, said second plurality of optical fibers having a cross-sectional area adjacent said coupling that is in the range of about two to about four times said certain cross-sectional area of said first plurality.

10. The device of claim 9 wherein said housing has a longitudinal axis, and wherein said first plurality of optical fibers and said second plurality of optical fibers each extend along generally 90 degree paths that include a portion generally parallel to said longitudinal axis and a portion generally perpendicular to said longitudinal axis.

11. The system of claim 1 wherein said at least one signal converter comprises at least one analog to digital signal converter.

12. The system of claim 1 wherein said device includes an optical reference material, a first reference pathway for directing a portion of the light from said at least one light source toward said reference material and a second reference pathway for directing light from said reference material toward said at least one light detector.

13. The system of claim 1 wherein said output signal is an electrical output signal.

14. The system of claim 1 wherein said output signal is a telemetric output signal.

15. The system of claim 1 wherein said housing surrounds said at least one light source and said at least one light detector.

16. A device for measuring one or more parameters of blood comprising:

a housing having a coupling for releasable connection to a blood parameter measurement cassette having a sensor;

a light source;

a first set of optical fibers optically coupled to said light source;

a first light detector and a second light detector;

an optical reference material; and

a second set of optical fibers coupled to said light detectors, said first set of optical fibers including a first group of optical fibers for directing light from said light source to the sensor and a second group of optical fibers for directing light from said light source to said reference material, said second set of optical fibers including a first group of optical fibers for directing light from the sensor to said first light detector and a second group of optical fibers for directing light from said reference material to said second detector; and

a signal converter connected to each light detector, said signal converter providing at least one output signal that varies in response to the quantity of light detected by said first detector and said second detector, wherein said light source, said light detector, said first set of optical fibers, said second set of optical fibers, said reference material and said signal converter are all contained within said housing.

17. The device of claim 16 including an optical fiber terminal block located next to said coupling, said reference material being fixed to said terminal block, said first group of said first set, said second group of said first set, said first group of said second set and second group of said second set each having at least one end that is fixed to said terminal block.

18. The device of claim 17 wherein said terminal block is fixed to said coupling.

19. The device of claim 17 wherein said coupling includes an opening, wherein said terminal block has a protrusion that extends into said opening, and wherein said first group of said first set and said first group of said second set each have an end that is located within said protrusion.

20. The device of claim 19 wherein said protrusion is elongated and wherein said device includes at least one additional set of fibers having an end that is located within said protrusion in spaced relationship along the longitudinal axis of said protrusion relative to said end of said first group of said first set and said end of said first group of said second set that are respectively located within said protrusion.

21. The device of claim 16 wherein said at least one output signal is a digital output signal.

22. The device of claim 16 wherein said light source is a single gallium nitride light emitting diode.

23. A system for measuring one or more parameters of blood comprising:

a device having an elongated housing with a coupling, at least one light source fixed to said housing and at least one light detector fixed to said housing; and

a cassette having wall sections defining a chamber for receiving a quantity of blood, said cassette including a coupling for releasably connecting said cassette to said device, said cassette including at least one sensor connected to said wall sections for sensing at least one parameter of the blood in said chamber, wherein said chamber includes an inlet port and an outlet port for enabling the flow of blood through said chamber along a certain path, and wherein said certain path extends in a direction substantially parallel to the longitudinal axis of said housing.

24. The system of claim 23, wherein said at least one sensor comprises at least one fluorescent sensor.

25. The system of claim 23, wherein said device includes a signal converter coupled to said housing and connected to said at least one light detector, said signal converter providing an output signal that varies in response to the quantity of light detected by said at least one light detector.

26. The system of claim 25, wherein said signal converter comprises at least one analog to digital signal converter.

27. The system of claim 25, wherein said signal converter and said at least one light source are positioned in locations that are arranged along the longitudinal axis of said housing.

28. The system of claim 23, wherein said at least one light source comprises at least one solid state light source.

29. The device of claim 28, wherein said at least one solid state light source is a gallium nitride light emitting diode.

30. The system of claim 23, wherein said device includes a first plurality of optical fibers that extend from said at least one light source and a second plurality of optical fibers that extend from said at least one light detector, said first plurality having a certain cross-sectional area adjacent said coupling, and wherein said second plurality of optical fibers has a cross-sectional area adjacent said coupling that is in the range of about two to about four times said certain cross-sectional area of said first plurality.

31. The device of claim 30, wherein said second plurality of optical fibers has a cross-sectional area adjacent said coupling that is about three times said certain cross-sectional area of said first plurality.

32. The system of claim 23, wherein said device includes a first plurality of optical fibers that extend from said at least one light source and a second plurality of optical fibers that extend from said at least one light detector, said first plurality and said second plurality each extending along generally 90 degree paths toward said at least one sensor when said cassette is coupled to said device.

33. The system of claim 23, wherein said at least one light source and said at least one light detector are contained within said housing.