Apparatus for automatic administration of multiple doses of drugs

• US 6,010,492 A
• Filed: 06/16/1998
• Issued: 01/04/2000
• Est. Priority Date: 02/07/1997
• Status: Expired due to Term

• Current Assignee: SARCOS LC (Sarcos Technology & Robotics Corp.)
• Original Assignee: SARCOS LC (Sarcos Technology & Robotics Corp.)
• Inventors: Jacobsen, Stephen C., Zentner, Gaylen M.
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US09/098,056
• Time in Patent Office: 567 Days
• Field of Search: 604/500, 604/501, 604/503, 604/93, 604/131, 604/175, 604/140
• US Class Current: 604/503
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

The apparatus for automatic administration and dosing of one or more drugs comprises a microdelivery device which may be implanted in or otherwise administered to an animal or human. The microdelivery device is configured to have at least one compartment containing at least one drug so that a plurality of doses of the drug(s) are held within the device. In accordance with the present invention, the microdelivery device selectively actuates a compartment to selectively release doses of the drug(s) to provide an efficacious dosing pattern. The microdelivery device employs a microprocessor, such as an application specific integrated circuit (ASIC), preprogrammed with a desired dosing regimen and a timing circuit, such as a quartz oscillator, in order to administer the drug(s) according to the dosing regimen. Thus, the microdelivery device is programmable to effectuate the release of the drug(s) at a desired time to maintain efficacious levels of the drug while minimizing the amount of drug which must be used.

Claims

1. An apparatus for automatic delivery of multiple doses of at least one drug, comprising:

containment means for containing at least one drug therein;

actuation means for selectively dispensing a substantially precise dose of the at least one drug from the containment means;

controller means for substantially precisely controlling the actuation means in accordance with a desired dosing regimen; and

timing means for providing a timing signal to the controller means thereby allowing the controller means to control the actuation means at a substantially precise time.

2. The apparatus of claim 1, wherein said containment means comprises a housing having at least one compartment defined therein.

3. The apparatus of claim 1, wherein said containment means comprises a reservoir.

4. The apparatus of claim 1, wherein said activation means comprises a propellant and an ignition source.

5. The apparatus of claim 1, wherein said activation means comprises a pump.

6. The apparatus of claim 1, wherein said controller means comprises an application specific integrated circuit.

7. The apparatus of claim 6, wherein said application specific integrated circuit comprises a microprocessor.

8. The apparatus of claim 1, wherein said timing means comprises a quartz oscillator.

9. The apparatus of claim 1, wherein said activation means further comprises receiving means for receiving a remote signal and for adjusting the dosing regimen of the controller means.

10. The apparatus of claim 9, wherein said receiving means comprises a radio signal receiver.

11. The apparatus of claim 1, further comprising monitoring means in communication with said controller means and a patient for monitoring at least one physiological condition of the patient and for generating data representing the at least one physiological condition, and wherein said controller means automatically adjusts the dosing regimen according to said data.

12. The apparatus of claim 11, wherein said monitoring means comprises a blood glucose level monitoring device.

13. The apparatus of claim 1, further includes a catheter in fluid communication with said containment means.

14. The apparatus of claim 1, further including attachment means for securing the containment means, activation means, controller means, and timing means to a body part of the patient.

15. The apparatus of 1, further including an IV set in fluid communication with the containment means.

16. An apparatus for automatic delivery of multiple doses of at least one drug, comprising:

a drug container for containing at least one drug therein;

an actuator for selectively dispensing a substantially precise dose of the at least one drug from the drug container;

a microprocessor for substantially precisely controlling the actuator in accordance with a desired dosing regimen; and

a timing device for providing a timing signal to the microprocessor thereby allowing the microprocessor to control the actuator at a substantially precise time.

17. The apparatus of claim 16, wherein said container comprises a plurality of compartments disposed therein, each holding at least one drug.

18. The apparatus of claim 17, wherein said plurality of compartments contain a first quantity of the at least one drug and a plurality of the remaining compartments contain a second quantity of the at least one drug which is less than the first quantity.

19. The apparatus of claim 18, wherein one of the plurality of compartments contains a first quantity of the at least one drug and a plurality of the remaining compartments contain a second quantity of the at least one drug which is greater than the first quantity.

20. The apparatus of claim 18, wherein a plurality of the compartments contain different quantities of the at least one drug.

21. The apparatus of claim 17, wherein said drug container is implantable within a patient.