Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas

• US 6,010,498 A
• Filed: 10/06/1997
• Issued: 01/04/2000
• Est. Priority Date: 03/13/1990
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Guglielmi, Guido
• Primary Examiner(s): COHEN, LEE S
• Application Number:
  US08/944,580
• Time in Patent Office: 820 Days
• Field of Search: 606/32, 606/41, 606/49, 606/28, 606/108, 606/191, 606/200, 600/569, 600/585, 604/104, 607/122, 623/1, 623/12
• US Class Current: 606/32
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/00292 mounted on or guided by flexible, e.g. catheter-like, means
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61B 2017/12095 Threaded connection
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2018/00678 upper
• CPC Class Codes: A61B 2018/00761 Duration
• CPC Class Codes: A61B 2018/00875 Resistance or impedance
• CPC Class Codes: A61B 2018/00886 Duration
• CPC Class Codes: A61B 2018/1226 powered by a battery
• CPC Class Codes: A61B 2018/1253 monopolar
• CPC Class Codes: A61B 2018/126 bipolar
• CPC Class Codes: A61B 2018/1266 with DC current output
• CPC Class Codes: A61B 2018/1435 Spiral
• CPC Class Codes: A61B 2018/1495 : Electrodes being detachable from a support structure
• CPC Class Codes: A61B 2090/3966 : Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 90/39 : Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61M 2025/09175 : having specific characteristics at the distal tip
• CPC Class Codes: A61M 25/09 : Guide wires

Abstract

An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.

Claims

1. An apparatus for forming an occlusion within a body cavity comprising:

a catheter;

a wire; and

a detachable elongate tip portion coupled to a distal portion of said wire which is retrievable until detached, said tip portion being adapted to be positioned in said body cavity to form an occlusion in said body cavity using one or more implantations of detachable elongate tip portions from corresponding wires, said wire having a radioopaque marker disposed thereon proximal on said wire from a detachment point of said elongate tip portion from said wire by a predetermined distance, said catheter having two radioopaque markers disposed thereon and spaced apart from each other, wherein one of said two markers on said catheter is provided at a distal end of said catheter and said other marker is positioned proximally thereof,

wherein said radioopaque markers are disposed on said wire and said catheter so that when said marker at said distal end of said catheter is disposed adjacent to an opening of said body cavity and when said wire is telescopically disposed in said catheter to approximately align said wire'"'"'s radioopaque marker with said more proximal catheter marker, said detachable elongate tip portion then is fully disposed in said body cavity.

2. The combination of claim 1 wherein full deployment of said detachable elongate tip portion in said body cavity positions a coupling of said detachable elongate tip portion to said wire approximately 2-3 mm past said opening of said body cavity.

3. The combination of claim 1 wherein said detachable elongate tip portion is a long and substantially pliable segment adapted to be multiply folded upon itself to substantially pack said body cavity.

4. The combination of claim 1 wherein said detachable elongate tip portion is 4-40 cm in length.

5. The combination of claim 1 wherein said wire and detachable elongate tip portion are coupled by polyester.

6. The combination of claim 1 wherein said tip portion is detachable from said wire by electrolytic disintegration of part of said wire.

7. An apparatus for forming an occlusion within a body cavity comprising:

a catheter with a proximal end and a distal end;

a wire; and

a detachable elongate tip portion coupled to a distal portion of said wire which is retrievable until detached, said detachable elongate tip portion having a proximal end when detached from said wire, said tip portion being adapted to be positioned in said body cavity to form an occlusion in said body cavity using one or more implantations of detachable elongate tip portions from corresponding wires, said wire having a radioopaque marker disposed on said wire a predetermined distance from a detachment section of said elongate tip portion from said wire, said catheter having at least one radioopaque marker disposed thereon,

wherein said radioopaque markers are disposed on said wire and said catheter so that when said distal end of said catheter is positioned at an opening of said body cavity to be occluded and said wire is telescopically disposed in said catheter to approximately align said radioopaque marker on said wire with said radioopaque marker on said catheter, said proximal end of said detachable elongate tip portion is then disposed when detached within said body cavity.

8. The combination of claim 7 wherein full deployment of said detachable elongate tip portion in said body cavity positions a coupling of said detachable elongate tip portion to said wire approximately 2-3 mm past said opening of said body cavity.

9. The combination of claim 7 wherein said detachable elongate tip portion is a long and substantially pliable segment adapted to be multiply folded upon itself to substantially pack said body cavity.

10. The combination of claim 7 wherein said detachable elongate tip portion is 4-40 cm in length.

11. The combination of claim 7 wherein said wire and detachable elongate tip portion are coupled by polyester.

12. The combination of claim 7 wherein said tip portion is detachable from said wire by electrolytic disintegration of part of said wire.