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Pharmaceutical composition for transdermal administration

  • US 6,010,716 A
  • Filed: 12/03/1997
  • Issued: 01/04/2000
  • Est. Priority Date: 03/30/1995
  • Status: Expired due to Term
First Claim
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1. Pharmaceutical composition for transdermal administration, comprising:

  • a) optionally, a polymeric release matrix capable of forming a flexible film after drying, selected from the group consisting of cellulose polymers and cellulose copolymers,b) an active principlec) 15 to 30% of the weight of the composition of a promoter of transcutaneous absorption of the active principled) 44 to 84.9% of the weight of the composition of a physiologically acceptable non-aqueous solvent appropriate to dissolve the active principle, the transcutaneous absorption promoter and, if present, the release matrix and be rapidly removed by evaporation on contact with the skin,the transcutaneous absorption promoter being selected from the group consisting of;

    an aliphatic fatty acid ester which is soluble in the physiologically acceptable non-aqueous solvent and is of general formula;

    ##STR2## in which R is selected from the group consisting of a linear or branched C2 -C17 alkyl or alkenyl group and a linear or branched C2 -C17 alkyl or alkenyl group substituted with a radical selected from the group consisting of hydroxyl, carboxy and C1 -C4 acyloxy group and R1 is selected from the group consisting of a linear or branched C3 -C8 alkyl group and a linear or branched C3 -C8 alkyl group substituted with one or two hydroxyl groups, or R1 represents a group --CH2 --CH2 --O--(CH2)2 --O--CH2 -CH3, the aliphatic fatty acid ester containing a minimum of 10 carbon atoms and a maximum of 2 hydroxyl groupsan aliphatic fatty alcohol which is soluble in the physiologically acceptable non-aqueous solvent and is of general formula;

    
    
    space="preserve" listing-type="equation">R.sub.2 --OH II in which R2 represents a C10 -C20 alkyl group.

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