Method of treating symptoms of microbial infection or sepsis
First Claim
1. A method of treating a patient with bacterial infection, so as to prevent release of bacterial endo-toxins, comprising:
- a) identifying a patient exhibiting symptoms of infection by bacteria, said bacteria having bacterial endotoxins;
b) administering to said patient an antimicrobial amount of an antimicrobial compound which is selected from the group consisting of non-antibiotic antimicrobial compounds which are cell wall constituent-inactivating by cell wall crosslinking, non-antibiotic antimicrobial compounds which are endotoxin non-releasing, non-antibiotic antimicrobial compounds which are exotoxin-inactivating, and combinations thereof, without administration of an antibiotic to said patient and prior to substantial administration of any antibiotic to said patient subsequent to step a) above, so as to substantially inactivate said bacteria without releasing said endo-toxins and substantially reduce said symptoms; and
c) then, after substantially inactivating in step b) said bacteria without releasing said endo-toxins and substantially reducing said symptoms with said antimicrobial compound, administering an antibiotic to said patient.
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Accused Products
Abstract
In accordance with the present invention, a method of treating a patient with symptoms of microbial infection and/or sepsis involves first administering to the patient an antimicrobial amount of a cell wall constituent-inactivating, endotoxin non-releasing, and/or exotoxin-inactivating antimicrobial compound such as Taurolidine and/or Taurultam, without administration of an antibiotic to the patient and prior to administration of such antibiotic. The Taurolidine and/or Taurultam are administered locally or intravenously to the patient to substantially inactivate microbes that are causing the infection. Only after substantially inactivating the microbes causing the infection with the Taurolidine and/or Taurultam, is an antibiotic administered to the patient.
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Citations
12 Claims
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1. A method of treating a patient with bacterial infection, so as to prevent release of bacterial endo-toxins, comprising:
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a) identifying a patient exhibiting symptoms of infection by bacteria, said bacteria having bacterial endotoxins; b) administering to said patient an antimicrobial amount of an antimicrobial compound which is selected from the group consisting of non-antibiotic antimicrobial compounds which are cell wall constituent-inactivating by cell wall crosslinking, non-antibiotic antimicrobial compounds which are endotoxin non-releasing, non-antibiotic antimicrobial compounds which are exotoxin-inactivating, and combinations thereof, without administration of an antibiotic to said patient and prior to substantial administration of any antibiotic to said patient subsequent to step a) above, so as to substantially inactivate said bacteria without releasing said endo-toxins and substantially reduce said symptoms; and c) then, after substantially inactivating in step b) said bacteria without releasing said endo-toxins and substantially reducing said symptoms with said antimicrobial compound, administering an antibiotic to said patient. - View Dependent Claims (2, 3, 5, 6, 7, 8, 9, 10, 11, 12)
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4. The method of claim I wherein during step c), said antimicrobial compound is co-administered with said antibiotic.
Specification