Detection of biological molecules using chemical amplification and optical sensors
First Claim
1. An implantable amplification system comprising a biocompatible polymer matrix and an amplification component which produces a polyhydroxylated analyte signal upon interrogation by an optical system, wherein said amplification component requires photoelectron transfer for production of said signal and wherein said amplification component is other than an arylboronic acid.
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Abstract
Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
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Citations
14 Claims
- 1. An implantable amplification system comprising a biocompatible polymer matrix and an amplification component which produces a polyhydroxylated analyte signal upon interrogation by an optical system, wherein said amplification component requires photoelectron transfer for production of said signal and wherein said amplification component is other than an arylboronic acid.
- 12. An implantable amplification system comprising a biocompatible polymer matrix and an amplification component, said amplification component comprising glucose oxidase, horseradish peroxidase and parahydroxyphenylacetic acid, which produces a polyhydroxylated analyte signal upon interrogation by an optical system, wherein said amplification component does not require resonance energy transfer for production of said signal.
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14. An implantable amplification system comprising a biocompatible polymer matrix and an amplification component, wherein said amplification component comprises glucose oxidase and luminol, which produces a polyhydroxylated analyte signal upon interrogation by an optical system, wherein said amplification component does not require resonance energy transfer for production of said signal.
Specification