Dual electrode lead and method for brain target localization in functional stereotactic brain surgery

• US 6,011,996 A
• Filed: 01/20/1998
• Issued: 01/04/2000
• Est. Priority Date: 01/20/1998
• Status: Expired due to Term

• Current Assignee: Michael J. Jaro
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gijsberg, Johan F. M., Gielen, Frans L. H., Duysens, Victor P. J.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US09/009,247
• Time in Patent Office: 714 Days
• Field of Search: 607/116-118, 600/373, 600/378, 600/411, 600/417, 600/427, 600/429, 606/130
• US Class Current: 607/116
• CPC Class Codes: A61B 90/11 with guides for needles or instruments, e.g. arcuate slides or ball joints
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole

Abstract

A lead for brain target localization in functional stereotactic brain surgery, the lead having at its distal end a micro-electrode for use in recording single cell discharge patterns so as to identify functional boundaries between brain structures; and a macro-electrode for delivering test stimulation for determining target location for optimal therapeutic benefit and minimum side effects. The macro-test stimulation electrode is carried at the end of the lead length, and has a conventional surface area in the range of 1-20 mm² for stimulating chronic stimulation conditions. The micro-electrode is positioned at the distal end of an axially aligned probe which extends distally from the macro-electrode, and has a surface area adapted to enable a single cell recording; e.g., between 0.01 and 1000 μm². In an alternate embodiment, the tip micro-electrode is retractable so that the lead can be used for chronic brain stimulation.

Claims

1. A lead for brain target localization, comprising a proximal end and a distal end with a length therebetween, a casing covering the lead over said length, first and second conductors within said casing extending between said proximal and distal ends, and

a first stimulating electrode at said distal end and connected to said first conductor, said first electrode having a surface area in the range of about 1-20 mm² ;

and

a probe element extending more than 1 mm distally from said first electrode and carrying a micro-electrode at the probe element distal tip, said micro-electrode having a surface area in the range of 0.01 to 1000 μ

m², and being connected to said second conductor.

2. The lead as described in claim 1, wherein said probe has a length in the range of about 1-10 mm.

3. The lead as described in claim 2, wherein said lead length is substantially cylindrical, and said probe is positioned along the center axis of said lead.

4. The lead as described in claim 3, wherein said probe is less than about 0.2 mm in thickness.

5. The lead as described in claim 1, wherein said first electrode has a cylindrical surface congruent with said lead casing.

6. The lead as described in claim 1, wherein said micro-electrode has a surface area of less than 1 μ

m².

7. The lead as described in claim 1, wherein said micro-electrode has a surface area in the range of 500 to 1000 μ

m².

8. The lead as described in claim 1, comprising a stylet attached to said probe element, whereby said probe element can be withdrawn from said lead.

9. The lead as described in claim 1, wherein said length is at least 300 mm.

10. A system for brain target localization, comprising a stereotactic instrument mountable on a patient'"'"'s head, a lead comprising a proximal end and a distal end with a length therebetween for use in brain target localization, first and second conductors extending between said proximal and distal ends, a micro-positioner for positioning said lead when held by said stereotactic instrument so that said lead distal end is movable within the patient'"'"'s brain, stimulation means for delivering test stimulation pulses through said lead, and recording from said lead means for recording cell discharge patterns, said lead further comprising:

a first stimulating electrode at said distal end and connected to said first conductor, said first electrode having a surface area in the range of about 1-20 mm² ; and

a probe element extending more than 1 mm distally from said first electrode and carrying a micro-electrode at the probe element distal tip, said micro-electrode having a surface area in the range of 0.01 to 1000 μ

m², and being connected to said second conductor.

11. The system as described in claim 10, wherein said micro-electrode has a surface area of less than 1 μ

m².

12. The system as described in claim 10, wherein said micro-electrode has a surface area in the range of 500 to 1000 μ

m².

13. The system as described in claim 10, comprising a stylet attached to said probe element, whereby said probe element can be withdrawn from said lead.

14. The system as described in claim 10, wherein said length is at least 300 mm.