Particle delivery

• US 6,013,050 A
• Filed: 04/24/1997
• Issued: 01/11/2000
• Est. Priority Date: 10/20/1995
• Status: Expired due to Term

• Current Assignee: Powderject Research Limited (Pfizer Inc.)
• Original Assignee: Powderject Research Limited (Pfizer Inc.)
• Inventors: Greenford, John Christopher, Bellhouse, Brian John, Sarphie, David Francis, Drayson, Paul Rudd
• Primary Examiner(s): Coggins, Wynn Wood
• Assistant Examiner(s): NGUYEN, ANH TUAN TUONG
• Application Number:
  US08/847,430
• Time in Patent Office: 992 Days
• Field of Search: 604/68-72, 604/88, 604/139, 604/140, 604/141, 604/240, 604/243
• US Class Current: 604/70
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/3015 for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow cell injection devices C12M3/006
• CPC Class Codes: C12M 35/00 Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion machines for extracting juice from animal or plant tissue by electroplasmolysis A23N1/006, processes employing electric or wave energy B01J19/08; treatment of microorganisms or enzymes with electrical or wave energy C12N13/00; methods for cell fusion C12N15/02; introduction of foreign genetic material C12N15/87

Abstract

A needleless syringe particle delivery system is provided. The needleless syringe comprises an elongate nozzle which is connected at its upstream end to an open ended capsule chamber. The capsule chamber is configured to house and intimately enclose a nonrigid capsule containing particles of a therapeutic agent. An opening means is provided at the upstream end of the capsule chamber, and is used to pierce the upstream end of a capsule in the chamber. After the capsule is opened, an energizing means connected to the upstream end of the capsule chamber applies a gaseous pressure sufficient to force the particles out of the capsule and the open downstream end of the capsule chamber and thus to create through the nozzle a supersonic gas flow in which the particles are entrained.

Claims

1. A needleless syringe for administering particles of a therapeutic agent, said syringe comprising:

(a) an elongate nozzle having an upstream end;

(b) a capsule chamber interfaced with the upstream end of the nozzle to provide a chamber/nozzle interface, said chamber having an open upstream end and an open downstream end and providing a housing for containing a nonrigid capsule;

(c) opening means for mechanically piercing a nonrigid capsule when the capsule is arranged in the capsule chamber housing, said opening means arranged at the upstream end of the capsule chamber; and

(d) energizing means connected to the upstream end of the capsule chamber, wherein said energizing means comprises a source of pressurized gas and can be actuated to provide a gas flow through the capsule chamber and nozzle.

2. The syringe of claim 1 further comprising a nonrigid capsule arranged within the capsule chamber housing, wherein said capsule contains particles of a therapeutic agent.

3. The syringe of claim 2, wherein the capsule comprises substantially nonrigid gelatin walls and is cylindrical in shape.

4. The syringe of claim 1, wherein the capsule chamber is comprised of two portions which can be separated from each other to allow access to the capsule chamber housing.

5. The syringe of claim 4 further comprising a barrel portion that encases the capsule chamber and is attached to the upstream end of the elongate nozzle.

6. The syringe of claim 5, wherein attachment of the barrel portion to the nozzle resiliently holds the two portions of the capsule chamber together.

7. The syringe of claim 1, wherein the opening means comprises a cutting device which projects into the upstream end of the capsule chamber.

8. The syringe of claim 6, wherein the opening means comprises a cutting device which projects into the upstream end of the capsule chamber.

9. The syringe of claim 8, wherein attachment of the barrel portion to the needle brings the opening means into position to open a capsule when placed within the capsule chamber housing.

10. The syringe of claim 1 further comprising a second opening means arranged at the downstream end of the capsule chamber.

11. The syringe of claim 2, wherein the capsule comprises a weakened portion which allows a downstream end of said capsule to rupture upon application of gas pressure from the energizing means, thereby initiating a gas flow through the capsule and nozzle.

12. The syringe of claim 1, wherein the chamber/nozzle interface is closed by a rupturable membrane.

13. The syringe of claim 1, wherein the energizing means comprises a gas container housing pressurized gas.

14. The syringe of claim 13 further comprising release means which can be actuated to release a gas flow from the gas container to pass into the capsule chamber.

15. The syringe of claim 14, wherein the release means comprises a valve that can be actuated between open and closed positions.

16. The syringe of claim 15, wherein the valve is actuated by movement of two parts of the syringe relative to each other.