Sensor arrays for detecting analytes in fluids

• US 6,013,229 A
• Filed: 06/10/1998
• Issued: 01/11/2000
• Est. Priority Date: 03/27/1995
• Status: Expired due to Term

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Lewis, Nathan S., Freund, Michael S.
• Primary Examiner(s): Bell, Bruce F.
• Application Number:
  US09/095,376
• Time in Patent Office: 580 Days
• Field of Search: 422/88, 422/98, 422/82.01, 422/82.02, 422/68.1, 422/69, 204/406, 204/415, 204/418, 436/150
• US Class Current: 422/82.02
• CPC Class Codes: G01N 27/126 comprising organic polymers
• CPC Class Codes: G01N 33/0031 comprising two or more sensors, e.g. a sensor array electrochemical electrode arrays G01N27/27
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

A sensor array for detecting analyte in a fluid. The sensor comprises a substrate having an array of sensors. Each sensor comprises a combination of a first organic material at a concentration and a second organic material at a concentration, wherein the first organic material is different from the second organic material. The sensor array further includes a detector operatively associated with each said sensor. The sensor array is built from a feedstock of organic materials such that the number of sensors is greater than the number of different organic materials which form the sensors.

Claims

1. A sensor array for detecting an analyte in a fluid, comprising:

a substrate having an array of sensors, each sensor comprising a combination of a first nonconducting organic material at a first concentration, a second nonconducting organic material at a second concentration, and a conducting, material; and

a detector operatively associated with each sensor, said detector providing a response in the presence of said analyte.

2. The sensor array of claim 1, wherein each sensor comprises a chemically sensitive resistor.

3. The sensor array of claim 1, wherein the detector is an electrical measuring apparatus electrically connected to said sensors.

4. The sensor array of claim 1, wherein the first nonconducting organic material is a polymer.

5. The sensor array of claim 1, wherein the first nonconducting organic material is a homopolymer.

6. The sensor array of claim 1, wherein the first nonconducting organic material is a monomer.

7. The sensor array of claim 1, wherein each sensor is an interpenetrating network comprising a first polymer and a second polymer formed from a monomer polymerized in the presence of the first polymer.

8. A sensor array for detecting an anialyte in a fluid, comprising:

a first sensor comprising a combination of a first nonconducting organic material, a second nonconducting organic material, and a conducting material;

a sensor comprising a combination of a first nonconducting organic material, a second nonconducting organic material and a conducting material wherein the concentration of the first nonconducting organic material of the first sensor is different from the concentration of the first nonconducting organic material of the second sensor; and

a detector operatively associated with each said sensor.

9. The sensor array of claim 8, wherein each sensor comprises a chemically sensitive resistor.

10. The sensor array of claim 8, wherein the detector is an electrical measuring apparatus electrically connected to said sensors.

11. The sensor array of claim 8, wherein the first nonconducting organic material is a polymer.

12. The sensor array of claim 8, wherein the first nonconducting organic material is a homopolymer.

13. The sensor array of claim 8, wherein the first nonconducting organic material is a monomer.

14. The sensor array of claim 8, wherein each sensor is an interpenetrating network comprising a first polymer and a second polymer formed from a monomer polymerized in the presence of the first polymer.

15. A sensor array for detecting an analyte in a fluid, comprising:

a substrate having an array of sensors, each sensor comprising a combination of a first conducting material at a first concentration, a second conducting material at a second concentration, and a nonconductive organic material; and

a detector operatively associated with each sensor, said detector providing a response in the presence of said analyte.

16. The sensor array of claim 15, wherein the detector is an electrical measuring apparatus electrically connected to said sensors.

17. A sensor array for detecting an analyte in a fluid, comprising:

a first sensor comprising a combination of a first conducting material, a second conducting material, and a nonconducting organic material;

a second sensor comprising a combination of a first conducting material, a second conducting material, and a nonconducting organic material wherein the concentration of the first conducting material of the first sensor is different from the concentration of the first conducting material of the second sensor; and

a detector operatively associated with each said sensor.

18. The sensor array of claim 17, wherein the detector is an electrical measuring apparatus electrically connected to said sensors.