Antimicrobial nail coating composition

• US 6,013,677 A
• Filed: 01/06/1999
• Issued: 01/11/2000
• Est. Priority Date: 12/03/1996
• Status: Expired due to Term

• Current Assignee: Pacific World Corporation (PWC Holding Corp.)
• Original Assignee: Woodward Laboratories, Inc.
• Inventors: Dyer, David L.
• Primary Examiner(s): KRASS, FREDERICK F
• Application Number:
  US09/226,413
• Time in Patent Office: 370 Days
• Field of Search: 514/643, 424/61
• US Class Current: 514/643
• CPC Class Codes: A61K 2800/51 Chelating agents
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61Q 3/02 Nail coatings

Abstract

Antimicrobial nail coating compositions, and methods for treating and preventing microbial infections of the nail area, are provided. The antimicrobial nail coating compositions can be used to treat and/or prevent infections caused by microbes including bacteria, molds, spores, viruses and fungi, while providing a nail coating having acceptable handling and esthetic qualities. The compositions can include alcohol-containing solvents, and, as antimicrobial agents, quaternary amines or phenols.

Claims

1. A method for treating a microbial infection of the nail plate comprising applying to the nail a non-aqueous antimicrobial nail coating composition comprising:

(a) from about 5 percent to about 65 percent by weight of a film-forming polymer;

(b) from about 10 percent to about 80 percent by weight of an organic solvent; and

(c) from about 0.05 percent to about 5 percent by weight of an antimicrobial agent, wherein

said antimicrobial agent comprises solubilized benzalkonium chloride;

wherein the benzalkonium chloride

(1) is capable of leaching from said nail coating composition following transition of the nail coating from a liquid to a solid state following application;

(2) retains its antimicrobial activity following (1); and

(3) is not inactivated by isopropyl alcohol during storage,

wherein all weight percentages are based on the total weight of the nail coating composition.

2. The method of claim 1 wherein said antimicrobial agent comprises benzalkonium chloride having the formula ##STR2## wherein R is an alkyl group of from 1 to 24 carbon atoms.

3. The method of claim 1 wherein R is an alkyl group of from 10 to 17 carbon atoms.

4. The method of claim 1 wherein said nail coating composition further comprises from about 1 percent to about 80 percent by weight of a resin.

5. A method for treating a microbial infection of the nail plate comprising applying to the nail a non-aqueous antimicrobial nail coating composition comprising:

(a) from about 1 percent to about 80 percent by weight of a resin;

(b) from about 10 percent to about 80 percent by weight of an organic solvent; and

(c) from about 0.05 percent to about 5 percent by weight of an antimicrobial agent, wherein said antimicrobial agent comprises solubilized benzalkonium chloride;

wherein the benzalkonium cholride

(1) is capable of leaching from said nail coating composition following transition of the nail coating from a liquid to a solid state following application;

(2) retains its antimicrobial activity following (1); and

(3) is not inactivated by isopropyl alcohol during storage,

wherein all weight percentages are based on the total weight of the nail coating composition.

6. The method of claim 5 wherein said antimicrobial agent comprises benzalkonium chloride having the formula ##STR3## wherein R is an alkyl group of from 1 to 24 carbon atoms.

7. The method of claim 6 wherein R is an alkyl group of from 10 to 17 carbon atoms.