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High dynamic range apparatus for separation and detection of polynucleotide fragments

  • US 6,014,213 A
  • Filed: 03/18/1997
  • Issued: 01/11/2000
  • Est. Priority Date: 12/12/1994
  • Status: Expired due to Fees
First Claim
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1. An electrophoresis separation and real-time detection apparatus comprising:

  • (a) a housing adapted to receive an electrophoresis gel holder containing an electrophoresis gel loaded with fluorophore-labeled samples;

    (b) one or more laser diodes for providing radiation of a frequency suitable for excitation of the fluorophore;

    (c) means for directing the radiation to a plurality of excitation/detection sites on the electrophoresis gel;

    (d) an array of detectors aligned with the excitation/detection sites for collecting fluorescent emissions and producing an electrical output signal indicative of the intensity of the fluorescent emissions; and

    (e) means for increasing the dynamic range of the apparatus by at least one order of magnitude.

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