Ultrasonic system and method for tissue viability imaging

• US 6,015,384 A
• Filed: 08/31/1998
• Issued: 01/18/2000
• Est. Priority Date: 08/31/1998
• Status: Expired due to Term

• Current Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Original Assignee: Acuson Corporation (Siemens AG)
• Inventors: Main, Joan C., Ramamurthy, Bhaskar S.
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US09/144,843
• Time in Patent Office: 505 Days
• Field of Search: 600/440-441, 600/454-456
• US Class Current: 600/440
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61B 8/543 involving acquisition triggered by a physiological signal
• CPC Class Codes: G01S 15/8979 Combined Doppler and pulse-echo imaging systems
• CPC Class Codes: G01S 7/5206 Two-dimensional coordinated display of distance and direction; B-scan display
• CPC Class Codes: G01S 7/52071 Multicolour displays; using colour coding; Optimising colour or information content in displays, e.g. parametric imaging

Abstract

A method of imaging to aid tissue viability determinations is provided. Tissue motion is detected for at least region of tissue. Perfusion is estimated as a function of intensity data and time for the region of tissue. An image responsive to the detected tissue motion and the estimated perfusion is displayed. A combination of tissue motion imaging and perfusion estimation provides an assessment of tissue viability. If tissue exhibits perfusion and motion, then the tissue is likely normal. Any other perfusion and motion characteristic combination indicates abnormal tissue viability.

Claims

1. A method of imaging to aid tissue viability determinations comprising the steps of:

(a) detecting tissue motion corresponding to at least one point of in a tissue;

(b) estimating perfusion as a function of intensity data and time for the at least one point; and

(c) displaying an image responsive to the detected tissue motion and the estimated perfusion.

2. The method of claim 1 wherein step (c) comprises displaying a first image responsive to the detected tissue motion adjacent a second image responsive to the estimated perfusion.

3. The method of claim 1 wherein step (c) comprises overlaying a first image responsive to the estimated perfusion on a second image responsive to the detected tissue motion.

4. The method of claim 1 wherein step (c) comprises:

(c1) inputting first and second signals responsive to the detected tissue motion and the estimated perfusion, respectively;

(c2) outputting a third signal responsive to the first and second signals;

(c3) displaying the image responsive to the third signal.

5. An apparatus for imaging to aid tissue viability determinations, the apparatus comprising:

a processing structure for detecting tissue motion corresponding to at least one point of the tissue and for estimating perfusion as a function of intensity data and time for substantially the at least one point; and

a display device for displaying an image responsive to the detected tissue motion and the estimated perfusion.

6. The apparatus of claim 5 wherein the processing structure comprises at least two processors, one of said two processors for detecting tissue motion and another of said two processors for estimating perfusion.

7. The apparatus of claim 5 wherein the display device comprises a display device for displaying a first image responsive to the detected tissue motion adjacent a second image responsive to the estimated perfusion.

8. The apparatus of claim 5 wherein the display device comprises a display device for overlaying a first image responsive to the estimated perfusion on a second image responsive to the detected tissue motion.

9. The apparatus of claim 5:

further comprising a mapping table structure for receiving first and second signals responsive to the detected tissue motion and the estimated perfusion, respectively, and for outputting a third signal responsive to the first and second signals; and

wherein the display device comprises a display for displaying the image responsive to the third signal.

10. A method of imaging to aid tissue viability determinations comprising the steps of:

(a) detecting tissue motion corresponding to at least one point of a tissue;

(b) estimating perfusion as a function of intensity and time for the at least one point; and

(c) outputting a signal responsive to the detected tissue motion and the estimated perfusion;

(d) displaying an image responsive to the signal.

11. The method of claim 10 wherein step (a) comprises Doppler processing.

12. The method of claim 11 wherein step (d) comprises displaying a color coded Doppler strip of frequency as a function of time.

13. The method of claim 10 wherein step (a) comprises correlation processing.

14. The method of claim 10 wherein step (b) comprises providing contrast agents.

15. The method of claim 14 wherein step (b) comprises calculating a transit time as a function of intensity.

16. The method of claim 14 wherein step (b) comprises:

(b1) substantially destroying contrast agents at the at least one point; and

(b2) calculating perfusion as a function of intensity and time.

17. The method of claim 14 wherein step (b) comprises:

(b1) triggering ultrasonic transmissions;

(b2) adjusting a triggering rate in response to intensity; and

(b3) calculating perfusion as a function of the triggering rate.

18. The method of claim 14 wherein step (b) comprises calculating a B-mode intensity value.

19. The method of claim 18 wherein step (b) comprises calculating a linear B-mode intensity value.

20. The method of claim 10 wherein step (b) comprises obtaining harmonic B-mode intensity data.

21. The method of claim 10 wherein step (c) comprises outputting the signal from a mapping structure.

22. The method of claim 21 wherein step (c) comprises outputting a color value from a two-dimensional look-up table.

23. The method of claim 10 wherein the at least one point comprises a region and wherein step (d) comprises displaying the image as a two-dimensional image of at least the region.

24. An apparatus for imaging to aid tissue viability determinations, the apparatus comprising:

a processing structure for detecting tissue motion corresponding to at least one point of a tissue and for estimating perfusion as a function of intensity data and time for substantially the at least one point;

a mapping structure for receiving first and second signals responsive to the detected tissue motion and the estimated perfusion, respectively, and for outputting a third signal responsive to the first and second signals; and

a display device for displaying an image responsive to the third signal.

25. The apparatus of claim 24 wherein the processing structure comprises a processor selected from the group consisting of:

Doppler and correlation processors.

26. The apparatus of claim 24 wherein the processing structure is operable to calculate a transit time as a function of intensity.

27. The apparatus of claim 24 further comprising a means for substantially destroying contrast agents at the at least one point;

and wherein the processing structure is operable to calculate perfusion as a function of a steady state intensity, a post destruction intensity and time.

28. The apparatus of claim 24:

further comprising a means for triggering ultrasonic transmissions; and

wherein the processing structure is operable to adjust a triggering rate in response to intensity measurements and to calculate perfusion as a function of the triggering rate.

29. The apparatus of claim 24 wherein the intensity data comprises linear B-mode values.

30. The apparatus of claim 24 wherein the intensity data comprises harmonic B-mode data.

31. The apparatus of claim 24 wherein the mapping structure comprises a look-up table.

32. The apparatus of claim 31 wherein the third signal comprises a color value.

33. The apparatus of claim 24 wherein the image comprises a color coded Doppler strip of frequency as a function of time.

34. The apparatus of claim 24 wherein the at least one point comprises a region and wherein the image comprises a two-dimensional image of at least the region.

35. A method of imaging to aid tissue viability determinations comprising the steps of:

(a) detecting tissue motion corresponding to at least one region of a tissue;

(b) estimating perfusion as a function of intensity for the at least one region;

(c) outputting a tissue viability display value representing one of at least three viability states associated with the at least one region and responsive to the detected tissue motion and the estimated perfusion; and

(d) displaying a tissue viability image responsive to the tissue viability display value.

36. The method of claim 35 wherein step (b) comprises estimating the perfusion as a binary indication.

37. The method of claim 35 wherein step (b) comprises estimating the perfusion as an absolute perfusion calculation.

38. The method of claim 35 wherein step (b) comprises estimating the perfusion as a calculation selected from the group consisting of:

wash-in, washout and washin washout.

39. The method of claim 35 wherein step (b) comprises estimating the perfusion as a function of a triggering rate.

40. The method of claim 35 wherein step (c) comprises outputting a color value.

41. The method of claim 40 wherein step (c) comprises outputting the color value corresponding to one of normal tissue, hibernating tissue, erroneous imaging, and necrosis.

42. An apparatus for imaging to aid tissue viability determination, the apparatus comprising:

a Doppler processing path for detecting tissue motion corresponding to at least one region of a tissue;

an intensity processing path for estimating perfusion as a function of intensity data corresponding to the at least one region;

a look-up table for outputting a tissue viability display value representing one of at least three viability associated with the at lest one region and responsive to the detected tissue motion and the estimated perfusion; and

a display for displaying a tissue viability image responsive to the tissue viability display value.