Method and apparatus for magnetically controlling motion direction of a mechanically pushed catheter

• US 6,015,414 A
• Filed: 08/29/1997
• Issued: 01/18/2000
• Est. Priority Date: 08/29/1997
• Status: Expired due to Term

• Current Assignee: Stereotaxis, Inc.
• Original Assignee: Stereotaxis, Inc.
• Inventors: Ritter, Rogers C., Blume, Walter M., Creighton, Francis M. IV, Werp, Peter R.
• Primary Examiner(s): Buiz, Michael
• Assistant Examiner(s): Woo, Julian W.
• Application Number:
  US08/920,446
• Time in Patent Office: 872 Days
• Field of Search: 600/12, 604/276, 604/95, 606/108, 606/130
• US Class Current: 606/108
• CPC Class Codes: A61B 2034/732 arranged around the patient, e.g. in a gantry
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 34/73 Manipulators for magnetic surgery
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 90/10 for stereotaxic surgery, e.g. frame-based stereotaxis
• CPC Class Codes: A61M 25/01 Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence
• CPC Class Codes: A61M 25/0127 Magnetic means; Magnetic markers

Abstract

The movement of a catheter through a medium, which may be living tissue such as a human brain, is controlled by mechanically pushing a flexible catheter having a magnetic tip through the medium and applying a magnetic field having a magnitude and a direction that guides the mechanically-pushed catheter tip stepwise along a desired path. The magnetic field is controlled in a Magnetic Stereotaxis System by a processor using an adaptation of a PID (proportional, integral, and derivative) feedback method. The magnetic fields are applied by superconducting coils, and the currents applied through the coils are selected to minimize a current metric.

Claims

1. A method for controlling movement of a catheter through a medium, the method comprising the steps of:

(a) mechanically pushing a flexible catheter having a magnetic tip through the medium; and

(b) applying a magnetic field having a magnitude and an orientation effective to guide the mechanically-pushed catheter tip in a predetermined direction.

2. The method of claim 1 and further comprising the steps of sensing catheter tip positions, and adjusting the applied magnetic field so that the catheter tip advances stepwise at least approximately along a predetermined path.

3. The method of claim 1 and further comprising the steps of:

sensing catheter tip positions;

generating a signal indicative of the position of the catheter tip;

determining a correction vector between the position of the catheter tip and the predetermined path at least partially in response to said generated signal; and

adjusting the applied magnetic field at least partially in response to the determined correction vector so that the catheter tip advances at least approximately along a predetermined path.

4. The method of claim 3 further comprising the step of storing correction vectors in a memory, and wherein the determining step comprises determining the adjustment at least partially in response to a presently-determined correction vector and at least one of the previously stored correction vectors.

5. The method of claim 1 wherein the step of applying a magnetic field comprises the step of applying currents to a plurality of superconducting coils.

6. The method of claim 5 wherein the currents are selected to minimize a predetermined current metric.

7. The method of claim 5 wherein the currents are selected to minimize a current-limiting constraint set.

8. The method of claim 1 wherein the step of mechanically pushing the catheter comprises the step of pushing the catheter through living tissue.

9. The method of claim 8 wherein the living tissue is a human brain.

10. The method of claim 8 further comprising the steps of sensing catheter tip positions, and adjusting the applied magnetic field so that the catheter tip advances stepwise at least approximately along a predetermined path.

11. The method of claim 10 further comprising the steps of:

generating a signal indicative of the position of the catheter tip;

determining a correction vector between the position of the catheter tip and the predetermined path at least partially in response to said signal;

and wherein the adjustment step comprises determining the adjustment to the applied magnetic field at least partially in response to the determined correction vector.

12. The method of claim 11 further comprising the step of storing correction vectors in a memory, and wherein the determining step comprises determining the adjustment at least partially in response to a presently-determined correction vector and at least one previously stored correction vector.

13. The method of claim 11 further comprising the step of storing correction vectors in a memory, and wherein the determining step comprises determining the adjustment at least partially in response to a rate of change of correction vectors in a previous step.

14. The method of claim 11 further comprising the step of storing correction vectors in a memory, and wherein the determining step comprises determining the adjustment at least partially in response to an anticipated future error with respect to a planned path.

15. The method of claim 8 wherein the step of applying a magnetic field comprises the step of applying currents to a plurality of superconducting coils.

16. The method of claim 15 wherein the currents are selected to minimize a predetermined current metric.

17. The method of claim 15 wherein the currents are selected to minimize a current-limiting constraint set.

18. A method for stepwise movement of a catheter having a magnetic tip in a magnetic field, the method comprising the steps of:

(a) selecting a desired path of the catheter through living tissue;

(b) inserting the catheter tip into the living tissue;

(c) determining actual positions of the magnetic tip and associated correction vectors, the correction vectors representing differences between locations on the desired path and the actual positions of the magnetic tip;

(d) storing said correction vectors in a memory; and

(e) applying a magnetic field adjusted to achieve movement of the magnetic tip at least approximately along the desired path, the adjustment depending upon at least one stored correction vector;

wherein the determining step comprises determining a point p₁ on the desired path closest to the then actual position of the magnetic tip and computing a vector V_correction representing the distance and correction from the then actual position of the magnetic tip to the point p₁ ; and

wherein the step of applying the magnetic field comprises;

selecting a point p₂ a predetermined distance from p₁ along the desired path;

calculating a vector V_path directed from p₁ to p₂ ; and

changing the magnetic field to move the magnetic tip in accordance with a function of a vector V_step, where ##EQU21## in which;

V_lag is a lag-correction vector pointing to an inside of a local curvature of the planned path at point p₂ ; and

g is a gain factor.

19. A method for stepwise movement of a catheter having a magnetic tip in a magnetic field, the method comprising the steps of:

(a) selecting a desired path of the catheter through living tissue;

(b) inserting the catheter tip into the living tissue;

(c) determining actual positions of the magnetic tip and associated correction vectors, the correction vectors representing differences between locations on the desired path and the actual positions of the magnetic tip;

(d) storing said correction vectors in a memory; and

(e) applying a magnetic field adjusted to achieve movement of the magnetic tip at least approximately along the desired path, the adjustment depending upon at least one stored correction vector;

wherein the applying step is performed a plurality of times, each time resulting in movement of the magnetic tip from a then current position to another position, and at least some of the applying steps are dependent upon the correction vectors determined for positions of the magnetic tip prior to the then current position, and further wherein the step of storing correction vectors comprises retaining at least two consecutively determined correction vectors in memory, each determined for positions of the magnetic tip prior to the then current position, and the applied magnetic field is dependent upon a function of at least the two consecutively determined correction vectors.

20. The method of claim 19 wherein:

(a) the step of determining the correction vectors comprises, for each correction vector;

determining a point p₁ on the desired path closest to the then current position of the magnetic tip; and

determining a correction vector V_correction representing the distance and direction from the then current position of the magnetic tip to the point p₁ ; and

(b) the step of applying the magnetic field further comprises;

selecting a point p2 a predetermined distance further along the desired path from p₁ ;

calculating a vector V_path representing the distance and direction from p₁ to p₂ ;

changing the magnetic field to move the magnetic tip in accordance with a function of a vector V_step, where ##EQU22## and where;

V_lag is a lag-correction vector pointing to an inside of a local curvature of the planned path at point p₁ ;

space="preserve" listing-type="equation">g=||k.sub.p V.sub.c(n) +k.sub.i (V.sub.c(n) +V.sub.c(n-1) +V.sub.c(n-2))+k.sub.d (V.sub.c(n) -V.sub.c(n-1))||,

where k_p, k_i, and k_d are predetermined constants; and

V_c(n), V_c(n-1), and V_c(n-2) are a correction vector determined for the then current position of the magnetic tip, a correction vector determined for a position of the magnetic tip before an immediately preceding magnetic field application, and a correction vector determined for a position of the magnetic tip before a second immediately preceding magnetic field application, respectively.

21. A method for stepwise movement of a catheter having a magnetic tip in a magnetic field, the method comprising the steps of:

(a) selecting a desired path of the catheter through living tissue;

(b) inserting the catheter tip into the living tissue;

(c) determining actual positions of the magnetic tip and associated correction vectors, the correction vectors representing differences between locations on the desired path and the actual positions of the magnetic tip;

(d) storing said correction vectors in a memory; and

(e) applying a magnetic field adjusted to achieve movement of the magnetic tip at least approximately along the desired path, the adjustment depending upon at least one stored correction vector;

(f) selecting a minimum radius of curvature for movement of the magnetic tip;

and wherein the step of applying the magnetic field comprises constraining said magnetic field so that the magnetic tip follows a trajectory having a curvature not less than the selected minimum radius of curvature.

22. A method for stepwise movement of a catheter having a magnetic tip in a magnetic field, the method comprising the steps of:

(a) selecting a desired path of the catheter through living tissue;

(b) inserting the catheter tip into the living tissue;

(c) determining actual positions of the magnetic tip and associated correction vectors, the correction vectors representing differences between locations on the desired path and the actual positions of the magnetic tip;

(d) storing said correction vectors in a memory; and

(e) applying a magnetic field adjusted to achieve movement of the magnetic tip at least approximately along the desired path, the adjustment depending upon at least one stored correction vector;

wherein the step of selecting a desired path comprises;

selecting an ideal path;

approximating the ideal path by parametric cubic polynomials, whereby the approximated path becomes the desired path; and

storing a representation of the parametric cubic polynomials in a memory.

23. The method of claim 22 further comprising selecting a minimum radius of curvature for movement of the magnetic tip;

and wherein the step of applying the magnetic field comprises constraining said magnetic field so that the magnetic tip follows a trajectory having a curvature not less than a predetermined minimum radius of curvature.

24. A method for stepwise movement of a catheter having a magnetic tip in a magnetic field, the method comprising the steps of:

(a) selecting a desired path of the catheter through living tissue;

(b) inserting the catheter tip into the living tissue;

(c) determining actual positions of the magnetic tip and associated correction vectors, the correction vectors representing differences between locations on the desired path and the actual positions of the magnetic tip;

(d) storing said correction vectors in a memory; and

(e) applying a magnetic field adjusted to achieve movement of the magnetic tip at least approximately along the desired path, the adjustment depending upon at least one stored correction vector;

wherein the application step comprises controlling currents through a plurality of coils, the currents in the coils are characterized by a root mean square value, and the application step includes minimizing the root mean square value of the coil currents for each application.

25. The method of claim 24 wherein the application step comprises adjusting currents in three pairs of coils.

26. A method for stepwise movement of a catheter having a magnetic tip in a magnetic field, the method comprising the steps of:

(a) selecting a desired path of the catheter through living tissue;

(b) inserting the catheter tip into the living tissue;

(c) determining actual positions of the magnetic tip and associated correction vectors, the correction vectors representing differences between locations on the desired path and the actual positions of the magnetic tip;

(d) storing said correction vectors in a memory; and

(e) applying a magnetic field adjusted to guide movement of the magnetic tip at least approximately along the desired path, the adjustment depending upon at least one stored correction vector; and

(f) pushing the catheter with a force not solely due to the applied magnetic field to thereby move the catheter under guidance of the magnetic field.

27. The method of claim 26 wherein the desired path has an endpoint, and the applying and pushing steps are performed a plurality of times until the magnetic tip approximately reaches the endpoint.

28. The method of claim 26 wherein the determining step comprises determining a point p₁ on the desired path closest to the then actual position of the magnetic tip and computing a vector V_correction representing the distance and correction from the then actual position of the magnetic tip to the point p₁.

29. The method of claim 26 wherein the applying step comprises applying the magnetic field in accordance with a predetermined function of at least a present correction vector, a previously stored correction vector, a lag-correction vector, and a vector along the desired path having a predetermined length, so that the magnetic tip advances at least approximately along the desired path when pushed by the catheter.

30. The method of claim 29 wherein the determining step comprises determining a point p₁ on the desired path closest to the then actual position of the magnetic tip and computing a vector V_correction representing the distance and correction from the then actual position of the magnetic tip to the point p₁.

31. The method of claim 26 wherein the applying and pushing steps are performed a plurality of times, each time resulting in movement of the magnetic tip from a then current position to another position, and at least some of the applying steps are dependent upon the correction vectors determined for positions of the magnetic tip prior to the then current position.

32. A method for moving a catheter having a magnetic tip disposed in a magnetic field stepwise along a path, the method comprising performing the steps of claim 26 first for a first desired path and then for a second desired path, and wherein applications of the magnetic field are responsive solely to correction vectors determined with respect to the respective paths.

33. The method of claim 26 wherein the application step comprises controlling currents through a plurality of superconducting coils.

34. The method of claim 33 wherein the application step comprises adjusting currents in three pairs of coils.

35. A method for controlling movement of a magnetic implant through living tissue, the method comprising the steps of:

(a) applying nonmagnetic forces to a flexible attachment mechanically attached to the implant; and

(b) magnetically steering the implant in a predetermined direction through the living tissue as it is pushed.

36. The method of claim 35 wherein the magnetic implant comprises a magnetically-tipped endoscope, and further comprising inserting the magnetic tip of the endoscope into the living tissue.

37. The method of claim 36 wherein the implant comprises a surgical device and the steering step comprises navigating the surgical device along the interior of a vessel.