Filtration device useable for removal of leukocytes and other blood components
First Claim
1. A method of processing biological liquid from an enclosed flexible supply bag through a filtration media of a processing system comprising:
- flowing biological liquid into an inlet and out of an outlet of said system;
automatically restricting the flow of biological liquid within said system downstream of a port, said port covered with a hydrophobic filter material to allow biological liquid to back up above the level of said port within said system during filtration, said port leading outside of said system and being located downstream of said inlet and upstream of said filtration media;
automatically preventing gas from entering into said processing system through said port by maintaining the level of biological liquid above the port until the flow of biological liquid from said flexible supply bag ceases; and
automatically allowing gas to enter the system through said port when the flow of liquid ceases thereby automatically draining biological liquid within said system.
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Accused Products
Abstract
A liquid filtration device useable for removing leukocytes from blood contains a first chamber which is in fluid flow relationship with a second chamber. Filtration elements separate the first chamber from the second chamber so that liquid flowing from the first chamber is filtered thereby prior to entry into the second chamber. A passage leads from the second chamber into the first chamber and a hydrophobic filter may be used to prevent liquid from the first chamber from flowing through the passage into the second chamber while allowing air to flow therethrough. An outlet is located in the second chamber, preferably at the bottom thereof. A second outlet may be located within the second chamber and may be placed in fluid flow relationship therewith by a conduit or the like.
65 Citations
54 Claims
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1. A method of processing biological liquid from an enclosed flexible supply bag through a filtration media of a processing system comprising:
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flowing biological liquid into an inlet and out of an outlet of said system; automatically restricting the flow of biological liquid within said system downstream of a port, said port covered with a hydrophobic filter material to allow biological liquid to back up above the level of said port within said system during filtration, said port leading outside of said system and being located downstream of said inlet and upstream of said filtration media; automatically preventing gas from entering into said processing system through said port by maintaining the level of biological liquid above the port until the flow of biological liquid from said flexible supply bag ceases; and automatically allowing gas to enter the system through said port when the flow of liquid ceases thereby automatically draining biological liquid within said system. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of filtering leukocytes from blood or a blood product in a sterile system comprising:
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flowing blood or blood product into an inlet and out of an outlet into a receiving container of said system; restricting the flow of blood or blood product downstream of a port and upstream of said receiving container during filtration to prevent external gas from entering into the system through said port and mixing with the blood or blood product, said port leading outside of said system and being covered with a hydrophobic filter media, said port being located downstream of said inlet and upstream or adjacent a leukocyte filter; flowing blood or blood product through the leukocyte filter, said leukocyte filter being located upstream of said outlet; automatically allowing gas to enter the system through the port when the flow of blood or blood product ceases to thereby automatically drain blood or blood product remaining within the system. - View Dependent Claims (9, 10, 11)
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12. A method of processing a biological liquid comprising:
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flowing biological liquid through an inlet of a processing system, said processing system having a port therein covered with a hydrophobic filter media, said port leading to outside of said system and adapted to keep the system sterile; restricting the flow of liquid downstream of the port and upstream of an outlet of said processing system while flowing said liquid through the system and through a filtration media so that the pressure head of the liquid in the system at the level of said port is greater than atmospheric pressure, said port being located downstream of said inlet and upstream of said outlet; and automatically allowing gas to enter the port when the pressure of the liquid in the system at the level of the port becomes less than atmospheric pressure to drain biological liquid remaining within the system into a receiving container. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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19. A biological liquid filtration system including a receiving container, comprising:
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a filtration media within said system adapted to allow biological liquid to flow therethrough for filtration; a self-contained automatic venting unit, said venting unit comprising an inlet, an outlet and an automatic vent, wherein the outlet is located upstream of the filtration media; said automatic vent comprising a port covered with a hydrophobic filtration media, said automatic vent being located downstream of said inlet and upstream of said filtration media, said automatic vent leading outside of said system and being adapted to prevent gas from entering said system through said port while the biological liquid flows downstream of said port until the flow of biological liquid ceases and then automatically allow gas to enter the system through said port after the flow of biological liquid ceases and then drain biological liquid from within said system into the receiving container. - View Dependent Claims (20, 21, 22, 23, 24)
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25. A method of filtering leukocytes from blood or a blood product within a filtration system comprising:
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flowing the blood or blood product from a flexible supply bag through an inlet and through a leukocyte filter wherein an outlet is located downstream of said inlet; automatically restricting the flow of blood or blood product downstream of the inlet and upstream or adjacent to said leukocyte filter during filtration to prevent external gas from entering the system through a port and mixing with the blood or blood product within the system, said port covered by a hydrophobic filter media and located downstream of said inlet and upstream of said filter; and automatically allowing gas to enter the port when the flow of blood or blood product ceases, to thereby allow blood or blood product to drain through the leukocyte filter.
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26. A method of filtering leukocytes from blood or a blood product comprising:
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flowing blood or the blood product into an inlet and out of an outlet of a filtration system; flowing the blood or blood product through a leukocyte filter of said filtration system; automatically restricting the flow of blood or blood product downstream of said inlet and upstream of said outlet to prevent external gas from entering the system, during filtration, through a port and mixing with the blood or blood product within the system, said port covered with a hydrophobic filter media and located downstream of said inlet and upstream of said outlet; allowing gas to automatically enter the port when the flow of blood or blood product ceases, thereby allowing blood or blood product in the system to drain. - View Dependent Claims (27, 28, 29, 30)
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31. A method of processing biological liquid through a filtration media of a processing system comprising:
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flowing biological liquid within said system through said filtration media located between an inlet and an outlet of the processing system; automatically restricting the flow of said biological liquid within said system upstream of said outlet while filtration occurs to cause the pressure of biological liquid at a level of a port covered with a hydrophobic filter media within said system to be greater than atmospheric pressure; preventing gas from entering into the processing system through said port located upstream of said filtration media and downstream of said inlet by maintaining the pressure of biological liquid at the level of said port above atmospheric pressure; and automatically allowing gas to enter the system through the port when the pressure of biological liquid within the system at the level of the port is less than atmospheric pressure thereby draining biological liquid within said system through said outlet. - View Dependent Claims (32, 33, 34, 35, 36, 37)
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38. A method of processing a biological liquid comprising:
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flowing biological liquid through an inlet of a processing system, said processing system having a port therein covered with a hydrophobic filter media, said port leading to outside of said system and adapted to keep the system sterile; restricting the flow of liquid downstream of the port and upstream of an outlet of said processing system while flowing said liquid through the system including a narrow-cross sectional area of the system wherein the pressure head of the fluid in the system at the level of said port is greater than atmospheric pressure, said port being located downstream of said inlet and upstream of said outlet; and automatically allowing gas to enter the port when the pressure of the liquid in the system at the level of the port becomes less than atmospheric pressure to drain biological liquid remaining within the system. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45)
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46. A method of processing a biological liquid comprising:
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flowing biological liquid through an inlet of a processing system, said processing system having a port therein covered with a hydrophobic filter media, said port leading to outside of said system and adapted to keep the system sterile; restricting the flow of liquid downstream of the port and upstream of an outlet of said processing system to prevent external gas from entering into the system through said port and mixing with the biological liquid while flowing said liquid through the system and through a filtration media, said port being located downstream of said inlet and upstream of said outlet; and automatically allowing gas to enter the system through the port when the flow of liquid ceases and thereby draining biological liquid remaining within the system into a receiving container.
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47. A method of processing a biological liquid comprising:
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flowing biological liquid through an inlet of a processing system, said processing system having a port therein covered with a hydrophobic filter media, said port leading to outside of said system and adapted to keep the system sterile; restricting the flow of liquid downstream of the port and upstream of an outlet of said processing system to prevent external gas from entering into the system through said port and mixing with the biological liquid while flowing said liquid through the system and through a narrow-cross section area in the system, said port being located downstream of said inlet and upstream of said outlet; and automatically allowing gas to enter the system through the port when the flow of liquid ceases and thereby draining biological liquid remaining within the system. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54)
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Specification