Anhydrous stable retinol based cosmetic or pharmaceutical composition

• US 6,015,568 A
• Filed: 04/04/1996
• Issued: 01/18/2000
• Est. Priority Date: 10/05/1993
• Status: Expired due to Fees

• Current Assignee: L'Oreal SA
• Original Assignee: L'Oreal SA
• Inventors: Segot, Evelyne, Laugier, Jean-Pierre
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Berman, Alysia
• Application Number:
  US08/627,480
• Time in Patent Office: 1,384 Days
• Field of Search: 424/401, 514/844, 514/845, 514/969
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/31 Anhydrous
• CPC Class Codes: A61K 2800/52 Stabilizers
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Anhydrous, stable retinol-based cosmetic or pharmaceutical composition for the skin. This composition contains solubilized retinol in an organic solution which is liquid at ambient temperature and which is chosen from the group comprising:

i) aliphatic fatty alcohols having a branched chain at C₁₆ -C₂₀,

ii) saturated alcoxylated fatty alcohols having a straight or branched chain at C₁₆ -C₂₀,

iii) the diesters of dicarboxylic esters at C₆ -C₁₄ and of isopropyl alcohol, and mixtures of these solvents.

This composition is intended for the treatment of skin disorders, and of acne in particular.

Claims

1. An anhydrous retinol based cosmetic lotion consisting of a cosmetically or pharmaceutically effective amount of retinol solubilized in an organic solvent liquid at ambient temperature, said organic solvent being selected from the group consisting of:

(i) a branched aliphatic alcohol having C₁₆ -C₂₀,

(ii) a straight or branched saturated alkyoxylated fatty alcohol having C₁₆ -C₂₀, and

a mixture thereof.

2. The anhydrous retinol based lotion of claim 1 wherein said retinol is present in a proportion of between 0.01 and 10 percent relative to the total weight of said composition.

3. The anhydrous retinol based lotion of claim 1 wherein said branched aliphatic fatty alcohol having C₁₆ -C₂₀ is selected from the group consisting of isostearyl alcohol, 2-hexyl decanol and octyl dodecanol.

4. The anhydrous retinol based lotion of claim 1 wherein said straight or branched saturated alkoxylated fatty alcohol is stearyl alcohol incorporating 15 moles of propylene oxide.

5. The anhydrous retinol based lotion of claim 1 wherein said composition contains no anti-oxidant.

6. A method of making a retinol based cosmetic or pharmaceutical lotion comprising at the time of use the step of mixing a first part packaging composed of a composition of claim 1 with a second part packaging composed of a cosmetically or pharmaceutically acceptable medium selected from the group consisting of a gel, an emulsion and an ointment.

7. The anhydrous retinol based lotion of claim 1 wherein said organic solvent is a C₁₆ branched aliphatic alcohol.