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Characterization of individual polymer molecules based on monomer-interface interactions

  • US 6,015,714 A
  • Filed: 06/16/1998
  • Issued: 01/18/2000
  • Est. Priority Date: 03/17/1995
  • Status: Expired due to Term
First Claim
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1. A method for sequencing a nucleic acid polymer, the method comprising:

  • providing two separate, adjacent pools of a medium and an interface between the two pools, the interface having a channel so dimensioned as to allow sequential monomer-by-monomer passage from one pool to the other pool of only one nucleic acid polymer at a time;

    placing the nucleic acid polymer to be sequenced in one of the two pools; and

    taking measurements as each of the nucleotide monomers of the nucleic acid polymer passes through the channel so as to sequence the nucleic acid polymer.

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