Tetrazole-containing rapamycin analogs with shortened half-lives
First Claim
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1. A compound having the formula ##STR7## or a pharmaceutically acceptible salt or prodrug thereof.
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Abstract
A compound having the formula ##STR1## or a pharmaceutically acceptible salt or prodrug thereof, is an immunomodulatory agent and is usefull in the treatment of restenosis and immune and autoimmune diseases. Also disclosed are cancer-, fungal growth-, restenosis-, post-transplant tissue rejection- and immune- and autoimmune disease-inhibiting compositions and a method of inhibiting cancer, fungal growth, restenosois, post-transplant tissue rejection, and immune and autoimmune disease in a mammal.
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3 Claims
- 1. A compound having the formula ##STR7## or a pharmaceutically acceptible salt or prodrug thereof.
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Current AssigneeAbbott Laboratories
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Original AssigneeAbbott Laboratories
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InventorsMollison, Karl W.
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Primary Examiner(s)Shah, Mukund J.
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Assistant Examiner(s)Kifle, Bruck
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Application NumberUS09/159,945Time in Patent Office481 DaysField of Search540/456, 514/291US Class Current514/291CPC Class CodesC07D 498/18 Bridged systems
