Intercalators having affinity for DNA and methods of use
First Claim
1. A compound having a formula I-Tm, m is an integer of 1 or 2, where T is 2, T is the same or different from one another, I is selected from the group consisting of:
- ##STR12## T is selected from the group consisting of;
##STR13##
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Abstract
Intercalator compounds of formula I-Tm as defined herein are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds provide a high affinity for binding to the DNA molecule and show reduced self-quenching, while providing superior transport kinetics. The compounds have been found to provide enhanced fluorescence when bound to a DNA molecule within a fluorescent flow cytometry environment which is about eight to ten times brighter in fluorescence than "bis" structure conventional intercalating agents and other known intercalating agents utilized in flow cytometry environment.
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Citations
9 Claims
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1. A compound having a formula I-Tm, m is an integer of 1 or 2, where T is 2, T is the same or different from one another, I is selected from the group consisting of:
- ##STR12## T is selected from the group consisting of;
##STR13##
- ##STR12## T is selected from the group consisting of;
- 2. A compound having the formula wherein A- is an acceptable monvalent counter anion.
- 4. A compound having the formula ##STR14## wherein A- is an acceptable monvalent counter anion.
- 6. A compound having the formula ##STR15## wherein A- is an acceptable monvalent counter anion.
- 8. A compound having the formula ##STR16## wherein A- is an acceptable monvalent counter anion.
Specification