Cardiac rhythm management system including nonlinear, non-blanking sense amplifier

• US 6,016,446 A
• Filed: 02/27/1998
• Issued: 01/18/2000
• Est. Priority Date: 02/27/1998
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Belalcazar, Hugo Andres
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US09/031,989
• Time in Patent Office: 690 Days
• Field of Search: 607/9, 607/17, 607/25, 607/13, 128/902, 128/901, 600/509
• US Class Current: 607/13
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold
• CPC Class Codes: A61N 1/3943 for threshold determination
• CPC Class Codes: Y10S 128/902 Biological signal amplifier

Abstract

A cardiac rhythm management system provides a nonlinear gain characteristic. The system operates without blanking switches that decouple its inputs from electrodes during delivery of a pacing or recharge pulse. The nonlinear gain characteristic includes piecewise linear and logarithmic gain characteristics. Signals having amplitudes that are smaller than an input threshold voltage are amplified by less than signals having amplitudes that exceed the input threshold voltage. Intrinsic heart activity signals are amplified. Detected pacing pulses are attenuated. The system is capable of detecting an evoked response to determine whether a pacing pulse resulted in a successful heart contraction. Autocapture techniques allow adjustment of the pacing pulse energy based on the evoked response.

Claims

1. A method comprising:

receiving a sensed signal, which includes a heart activity component, from a heart;

nonlinearly amplifying the sensed signal;

delivering pacing pulses to the heart based on the heart activity component of the nonlinearly amplified sensed signal; and

wherein amplifying the sensed signal includes amplifying during time periods in which the pacing pulses are being delivered to the heart.

2. The method of claim 1, in which amplifying the sensed signal includes an approximately piecewise linear amplifying of the sensed signal.

3. The method of claim 1, in which amplifying the sensed signal includes an approximately logarithmic amplifying of the sensed signal.

4. The method of claim 1, in which amplifying the sensed signal includes amplifying during time periods immediately following the time periods in which the pacing pulses are being delivered to the heart.

5. The method of claim 1, in which amplifying the sensed signal includes amplifying during recharge time periods following the time periods in which the pacing pulses are being delivered to the heart.

6. The method of claim 1, further including determining, based on the amplified sensed signal, whether the pacing pulse evoked a subsequent electrical depolarization of the heart.

7. The method of claim 6, further comprising adjusting the amplitude of the pacing pulses based on the step of determining whether the pacing pulse evoked a subsequent electrical depolarization of the heart.

8. The method of claim 1, in which amplifying the sensed signal includes attenuating a component of the sensed signal.

9. A method comprising:

receiving a sensed signal, which includes a heart activity component, from a heart;

amplfying the sensed signal by a first gain if an amplitude of the sensed signal is approximately less than or equal to an input threshold voltage;

amplifying the sensed signal by a second gain, which is less than the first gain, if the amplitude of the sensed signal approximately exceeds the input threshold voltage; and

delivering pacing pulses to the heart based on the heart activity component of the amplified sensed signal.

10. The method of claim 9, in which amplifying the sensed signal by a first gain includes amplifying by approximately 100 when the amplitude of the sensed signal is approximately less than or equal to the input threshold voltage of approximately 30 milliVolts.

11. The method of claim 9, in which amplifying the sensed signal by a second gain includes amplifying by approximately 0.08 when the amplitude of the sensed signal approximately exceeds the input threshold voltage of approximately 30 milliVolts.

12. The method of claim 9, in which the steps of amplifying the sensed signal by first and second gains include amplifying during time periods immediately following the time periods in which the pacing pulses are being delivered to the heart.

13. The method of claim 9, in which the steps of amplifying the sensed signal by first and second gains include amplifying during recharge time periods following the time periods in which the pacing pulses are being delivered to the heart.

14. The method of claim 9, further comprising determining, based on the amplified sensed signal, whether the pacing pulse evoked a subsequent electrical depolarization of the heart.

15. The method of claim 14, further comprising adjusting the amplitude of the pacing pulses based on the step of determining whether the pacing pulse evoked a subsequent electrical depolarization of the heart.

16. The method of claim 9, further comprising programming a value of at least one of the input threshold voltage, the first gain, and the second gain.

17. The method of claim 9, in which at least one of amplifying the sensed signal by a first gain and amplifying the sensed signal by a second gain includes attenuating a component of the sensed signal.

18. A cardiac rhythm management system comprising:

first and second electrodes;

a therapy module, coupled to the first and second electrodes for delivering pacing pulses to a heart; and

a sense amplifier, including an input and an output, the input coupled to the first and second electrodes for receiving a sensed signal including a heart activity component, the sense amplifier having a nonlinear gain characteristic, wherein the input of the sense amplifier is coupled to the first and second electrodes at least during time periods in which the pacing pulses are delivered to the heart.

19. The system of claim 18, in which the nonlinear gain includes a first gain at amplitudes of the sensed signal that are less than or equal to an input threshold voltage and, at amplitudes of the sensed signal that exceed the input threshold voltage, a second gain that is lower than the first gain.

20. The system of claim 18, in which the nonlinear gain is approximately piecewise linear.

21. The system of claim 20, in which the nonlinear gain includes a first gain of approximately 100 for input voltages that are below an input threshold voltage of approximately 30 milliVolts, and the nonlinear gain includes a second gain of approximately 0.08 for input voltages that are above the input threshold voltage.

22. The system of claim 21, in which at least one of the first gain, the second gain, and the input threshold voltage is programmable.

23. The system of claim 18, in which the nonlinear gain is approximately logarithmic.

24. The system of claim 18, in which the sense amplifier is coupled to the first and second electrodes including during time periods immediately after the time periods during which the pacing pulses are delivered to the heart.

25. The system of claim 18, in which the sense amplifier is coupled to the first and second electrodes including during recharge time periods following the time periods during which the pacing pulses are delivered to the heart.

26. The system of claim 18, further comprising an amplitude measurement module, coupled to the first and second electrodes for measuring the amplitude of the pacing pulses.

27. The system of claim 18, further including an evoked response detection module having an input and an output, the input coupled to the first and second electrodes, the evoked response detection module determining, based on the sensed signal, whether the pacing pulse evoked an electrical depolarization of the heart.

28. The system of claim 27, further comprising an autocapture module coupled the evoked response detection module and the therapy module for adjusting the amplitude of the pacing pulses based on the output of the evoked response detection module.

29. The system of claim 18, in which the sense amplifier is always coupled to the first and second electrodes.

30. The system of claim 18, in which the sense amplifier is directly connected to the first and second electrodes.

31. A cardiac rhythm management system comprising:

first and second electrodes;

a therapy module, coupled to the first and second electrodes for delivering pacing pulses to a heart; and

a sense amplifier, including an input and an output, the input coupled to the first and second electrodes for receiving a sensed signal including a heart activity component, the sense amplifier having a nonlinear gain characteristic that includes a first gain at amplitudes of the sensed signal that are less than or equal to an input threshold voltage, and a second gain, which is lower than this first gain, at amplitudes of the sensed signal that exceed the threshold voltage.

32. The system of claim 31, in which the nonlinear gain is approximately piecewise linear.

33. The system of claim 31, in which the nonlinear gain is approximately logarithmic.

34. The system of claim 31, in which the first gain is approximately 100.

35. The system of claim 31, in which the input threshold voltage is approximately 30 milliVolts.

36. The system of claim 31, in which the second gain is approximately 0.08.

37. The system of claim 31, in which at least one of the first gain, the second gain, and the input threshold voltage is programmable.

38. The system of claim 31, in which the sense amplifier is coupled to the first and second electrodes during time periods during which the pacing pulses are delivered to the heart.

39. The system of claim 38, in which the sense amplifier is always coupled to the first and second electrodes.

40. The system of claim 31, in which the sense amplifier is directly connected to the first and second electrodes.

41. The system of claim 31, in which the sense amplifier is coupled to the first and second electrodes during time periods that are immediately after the time periods during which the pacing pulses are delivered to the heart.

42. The system of claim 31, in which the sense amplifier is coupled to the first and second electrodes during recharge time periods following the time periods during which the pacing pulses are delivered to the heart.

43. The system of claim 31, further comprising an amplitude measurement module, coupled to the first and second electrodes for measuring the amplitude of the pacing pulses.

44. The system of claim 31, further including an evoked response detection module having an input and an output, the input coupled to the first and second electrodes, the evoked response detection module determining, based on the sensed signal, whether the pacing pulse evoked an electrical depolarization of the heart.

45. The system of claim 44, further comprising an autocapture module coupled the evoked response detection module and the therapy module for adjusting the amplitude of the pacing pulses based on the output of the evoked response detection module.