Feedback controlled drug delivery system
First Claim
1. An apparatus for delivering a therapeutic solution to a patient at an intravenous entry point during a first time period and removing a patient fluid sample from the intravenous entry point during a second time period for analysis, the apparatus comprising:
- a fluid supply tube connected to the therapeutic solution;
a sample tube junction connected to the fluid supply tube;
a bi-directional patient tube having a fluid flow and extending from the sample tube junction to the intravenous entry point, whereby the fluid flow is toward the intravenous entry point during the first time period and away from the intravenous entry point during the second time period;
a sample tube connected to the sample tube junction; and
a housing positioned on the sample tube, wherein the housing further comprises a pressure junction adjacent to the sample tube.
1 Assignment
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Accused Products
Abstract
A feedback controlled drug delivery system includes the automated sampling and analysis of a patient sample and dosing the patient based on the analysis. Automated sampling may be performed by direct analysis of the patient sample, such as for the measurement of a blood sample coagulation state or a glucose level. The drug delivery system includes a sample set that has a bidirectional patient tube that allows for delivery of the patient sample to an analyzer, and at another time, the infusion of a therapeutic drug. A controller receives a measurement from the analyzer, and based on that measurement, adjusts the delivery of the therapeutic fluid. The sample set has a quick--clear Leur fitting that allows for more effectively clearing a first fluid from a Leur fitting when starting a second fluid. The system also has a reagent cassette holder that protects, using a foam gasket, a reagent on a sample slide. Further, the system provides an interlock apparatus that assures a sample tube is occluded by either or both a slide clamp and by a platen arm compressing the sample tube to a peristaltic pump.
445 Citations
29 Claims
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1. An apparatus for delivering a therapeutic solution to a patient at an intravenous entry point during a first time period and removing a patient fluid sample from the intravenous entry point during a second time period for analysis, the apparatus comprising:
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a fluid supply tube connected to the therapeutic solution; a sample tube junction connected to the fluid supply tube; a bi-directional patient tube having a fluid flow and extending from the sample tube junction to the intravenous entry point, whereby the fluid flow is toward the intravenous entry point during the first time period and away from the intravenous entry point during the second time period; a sample tube connected to the sample tube junction; and a housing positioned on the sample tube, wherein the housing further comprises a pressure junction adjacent to the sample tube. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A device for the feedback controlled delivery of a therapeutic fluid to a patient, comprising:
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a catheter invasively attached to the patient and connected to a fluid supply tube; a therapeutic fluid source connected to the fluid supply tube and delivering the therapeutic fluid to the patient as directed by a controller; an analyzer for measuring the therapeutic solution in a patient sample, and communicating the results of the measurement to the controller; a sample tube connecting the analyzer to the fluid supply tube; a drawing pressure source operably connected to the sample line for creating a drawing pressure in the sample line, the drawing pressure being controlled by a controller; wherein the controller directs the drawing pressure to draw the patient sample to the analyzer, directs the analyzer to perform the measurement, receives the measurement, and directs the fluid source to deliver the therapeutic solution at a rate based on the measurement. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification