Molecular imaging
First Claim
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1. A molecular imaging device for imaging molecules within a biological sample, comprising:
- a UV light source arranged to shine onto a sample to be investigated;
a UV detector arranged to detect the position of molecules of a selected class by the molecular UV absorption of molecules of that class, wherein the detector comprises a single wafer of detector material, the wafer having a plurality of parallel sided grooves in a surface thereof thereby defining between the grooves and plurality of parallel sided detector elements, opposing sides of each element carrying opposing readout electrodes; and
means for applying a potential difference between the opposing electrodes of each element to create an electric field across the element.
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Abstract
A method of imaging molecules of interest within a biological sample includes shining a UV light onto the sample and detecting the molecular UV absorption. Where the molecules of interest are themselves UV absorbers, the intrinsic absorption of those molecules may be used. If the molecules of interest are not good UV absorbers, UV-absorbing tag molecules may be used. The method may be used in molecular imaging devices of all types, and in DNA sequencers. A novel diamond-based detector is disclosed which is suitable for many applications.
347 Citations
15 Claims
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1. A molecular imaging device for imaging molecules within a biological sample, comprising:
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a UV light source arranged to shine onto a sample to be investigated; a UV detector arranged to detect the position of molecules of a selected class by the molecular UV absorption of molecules of that class, wherein the detector comprises a single wafer of detector material, the wafer having a plurality of parallel sided grooves in a surface thereof thereby defining between the grooves and plurality of parallel sided detector elements, opposing sides of each element carrying opposing readout electrodes; and means for applying a potential difference between the opposing electrodes of each element to create an electric field across the element. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification