Methods for embolizing blood vessels
First Claim
1. A kit of parts comprising:
- (a) a polymer composition comprising a biocompatible polymer, a biocompatible solvent which is selected from an organic material liquid at least at body temperature of a mammal in which the biocompatible polymer is soluble and a contrast agent which is capable of being monitored during injection into the mammal by radiography; and
(b) a non-particulate agent or plurality of such agents wherein said agents are selected from the group consisting of metallic coils, coils with barbs, silk streamers, plastic brushes, detachable balloons, foam and nylon meshwherein said polymer composition comprises a sufficient amount of said polymer such that, upon discharge into a vascular site, a solid mass precipitates in the presence of the non-particulate agent to embolize said vascular site.
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Abstract
Disclosed are methods useful for treating vascular lesions wherein a non-particulate agent such as a metal coil is introduced into a vascular site (e.g., an aneurysm cavity) in conjunction with an embolizing composition comprising a biocompatible polymer and a biocompatible solvent.
The biocompatible solvent is miscible or soluble in blood and also solubilizes the polymer during delivery. The biocompatible polymer is selected to be soluble in the biocompatible solvent but insoluble in blood. Upon contact with the blood, the biocompatible solvent dissipates from the embolic composition whereupon the biocompatible polymer precipitates. Precipitation of the polymer in the presence of the non-particulate agent permits the agent to act as a structural lattice for the growing polymer precipitate.
In another embodiment, the biocompatible polymer composition can be replaced with a biocompatible prepolymer composition containing a biocompatible prepolymer.
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Citations
12 Claims
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1. A kit of parts comprising:
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(a) a polymer composition comprising a biocompatible polymer, a biocompatible solvent which is selected from an organic material liquid at least at body temperature of a mammal in which the biocompatible polymer is soluble and a contrast agent which is capable of being monitored during injection into the mammal by radiography; and (b) a non-particulate agent or plurality of such agents wherein said agents are selected from the group consisting of metallic coils, coils with barbs, silk streamers, plastic brushes, detachable balloons, foam and nylon mesh wherein said polymer composition comprises a sufficient amount of said polymer such that, upon discharge into a vascular site, a solid mass precipitates in the presence of the non-particulate agent to embolize said vascular site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification