Transdermal protein delivery or measurement using low-frequency sonophoresis
First Claim
1. A method for collecting an analyte to be measured in a blood or lymph sample comprisingapplying at an appropriate site for collection of a blood or lymph sample an effective amount of ultrasound at a frequency between 20 kH and 1.5 MHz to extract analyte in the absence of penetration enhancers andcollecting the blood or lymph sample at the site where the ultrasound is applied.
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Abstract
Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).
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7 Claims
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1. A method for collecting an analyte to be measured in a blood or lymph sample comprising
applying at an appropriate site for collection of a blood or lymph sample an effective amount of ultrasound at a frequency between 20 kH and 1.5 MHz to extract analyte in the absence of penetration enhancers and collecting the blood or lymph sample at the site where the ultrasound is applied.
Specification