Systems for harmonic ultrasound imaging

• US 6,019,960 A
• Filed: 06/27/1997
• Issued: 02/01/2000
• Est. Priority Date: 09/28/1994
• Status: Expired due to Fees

• Current Assignee: Targeson, Inc.
• Original Assignee: Alliance Pharmaceutical Corporation
• Inventors: Schutt, Ernest G.
• Primary Examiner(s): Hollinden, Gary E.
• Application Number:
  US08/884,542
• Time in Patent Office: 949 Days
• Field of Search: 424/9.52, 424/9.5, 600/458, 600/453
• US Class Current: 424/9.5
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61K 49/223 Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Abstract

A method for ultrasonic harmonic imaging is disclosed, which uses microbubbles particularly selected for their properties of reradiating ultrasound energy at frequencies other than the exciting frequency.

Claims

1. A system for ultrasonic harmonic imaging of an object or body comprising:

a transducer capable of emitting a fundamental frequency;

a receiver capable of detecting at least one frequency other than said fundamental frequency whereby said at least one detected frequency may be used to provide an image of at least a part of said object or body; and

a contrast agent comprising a plurality of microbubbles which, when insonated with the fundamental frequency, radiate ultrasonic energy at frequencies other than the fundamental frequency with an efficiency greater than a free air bubble.

2. The system of claim 1 wherein said microbubbles comprise at least one gas or vapor selected from the group consisting of sulfur hexafluoride, fluorocarbons and hydrocarbons.

3. The system of claim 2, wherein said gas or vapor comprises a compound selected from the group consisting of perfluorohexane, perfluoropentane, perfluorocyclopentane, 1,1,2-trichlorotrifluoroethane, sulfur hexafluoride, cyclopentane, methylene chloride, pentane, hexane, dichlorodifluoromethane, trichloromonofluoromethane, perfluorobutane, perfluorocyclobutane, perfluoropropane, butane, cyclobutane, propane, methane, and ethane.

4. The system of claim 3 wherein said microbubbles comprises a surfactant.

5. The system of claim 4 wherein said surfactant comprises a fluorinated surfactant.

6. The system of claim 4 wherein said surfactant is a non-Newtonian surfactant.

7. The system of claim 2 wherein said gas or vapor comprises a compound selected from the group consisting of perfluoropentane, perfluorohexane, perfluorobutane and perfluoropropane.

8. The system of claim 7 wherein said microbubbles comprises a surfactant.

9. The system of claim 8 wherein said surfactant is selected from the group consisting of phospholipids, sugar esters, block copolymers, zonyl surfactants, fatty acids, fatty acid salts and combinations thereof.

10. The system of claim 1 wherein said microbubbles comprise a gaseous or vaporous mixture comprising at least one gas osmotic agent and at least one modifier gas.

11. The system of claim 2 wherein said gas or vapor comprises perfluorohexane.

12. The system of claim 11 wherein said gas or vapor further comprises a modifier gas selected from the group consisting of nitrogen, oxygen, carbon dioxide and mixtures thereof.

13. The system of claim 12 wherein said microbubbles comprise a surfactant.

14. The system of claim 12 wherein said surfactant comprises a compound selected from the group comprising phospholipids, block copolymers and combinations thereof.

15. The system of claim 12 wherein the microbubbles comprise a proteinaceous material.

16. The system of claim 15 wherein said proteinaceous material is albumin.

17. The system of claim 2 wherein said gas or vapor comprises perfluoropropane.

18. The system of claim 17 wherein said microbubbles comprise one or more liposomes.

19. The system of claim 17 wherein said microbubbles comprise a surfactant.

20. The system of claim 19 wherein said surfactant comprises a compound selected from the group comprising phospholipids, block copolymers and combinations thereof.

21. The system of claim 17 wherein the microbubbles comprise a proteinaceous material.

22. The system of claim 21 wherein said proteinaceous material is albumin.

23. The system of claim 2 wherein said gas or vapor comprises perfluorobutane.

24. The system of claim 23 wherein said microbubbles comprise a surfactant.

25. The system of claim 2 wherein said gas or vapor comprises perfluoropentane.

26. The system of claim 25 wherein said microbubbles comprise a surfactant.

27. The system of claim 2 wherein said gas or vapor is sulfur hexafluoride.

28. The system of claim 27 wherein said microbubbles comprise one or more liposomes.

29. A system for harmonic imaging of an object or body comprising:

an ultrasound scanner capable of harmonically imaging said object or body; and

a contrast agent comprising a plurality of microbubbles wherein said microbubbles comprise at least one gaseous or vaporous compound selected from the group consisting of hydrocarbons, fluorocarbons and combinations thereof.

30. A system for harmonic imaging of an object or body comprising:

an ultrasound scanner capable of harmonically imaging said object or body; and

a contrast agent comprising an emulsified liquid wherein said emulsified liquid comprises water and perfluoropentane.

31. The system of claim 30 wherein said emulsified liquid further comprises a surfactant.

32. The system of claim 31 wherein a plurality of microbubbles may be formed in said contrast agent by boiling said emulsified liquid.

33. The system of claim 32 wherein the boiling of said emulsified liquid may be accomplished by altering the pressure thereon.

34. The system of claim 33 wherein said microbubbles further comprise a modifier gas selected from the group consisting of nitrogen, oxygen, carbon dioxide and mixtures thereof.

35. A system for harmonic imaging of an object or body comprising:

an ultrasound scanner capable of harmonically imaging said object or body; and

a contrast agent comprising a plurality of microbubbles wherein said microbubbles comprise perfluoropropane.

36. The system of claim 35 wherein said microbubbles comprise one or more liposomes.

37. The system of claim 35 wherein the microbubbles comprise a proteinaceous material.

38. The system of claim 37 wherein said proteinaceous material is albumin.

39. A system for harmonic imaging of an object or body comprising:

an ultrasound scanner capable of harmonically imaging said object or body; and

a contrast agent comprising a plurality of microbubbles wherein said microbubbles comprise perfluorohexane.

40. A system for harmonic imaging of an object or body comprising:

an ultrasound scanner capable of harmonically imaging said object or body; and

a contrast agent comprising a plurality of microbubbles wherein said microbubbles comprise sulfur hexafluoride.