Lubricious coatings

• US 6,020,071 A
• Filed: 11/26/1997
• Issued: 02/01/2000
• Est. Priority Date: 06/03/1995
• Status: Expired due to Term

• Current Assignee: Jeremy Watson
• Original Assignee: Jeremy Watson
• Inventors: Watson, Jeremy
• Primary Examiner(s): DUDASH, DIANA L
• Application Number:
  US08/973,250
• Time in Patent Office: 797 Days
• Field of Search: 427/2.28, 427/2.3, 427/2.12, 427/393.5, 427/421, 427/430.1, 428/423.1, 424/422, 525/453, 525/454, 508/239, 528/48, 528/52
• US Class Current: 428/423.1
• CPC Class Codes: A61L 2400/10 Materials for lubricating medical devices
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: C08G 18/0852 the solvents being organic
• CPC Class Codes: C08G 18/10 Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• CPC Class Codes: C08G 18/48 Polyethers
• CPC Class Codes: C08L 75/04 Polyurethanes
• CPC Class Codes: Y10T 428/31551 Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]

Abstract

A hydrophilic lubricious coating for an article comprising a non-toxic, cross-linked, hydrophilic polyurethane. The invention includes a method for preparing said lubricious coating, as well as a method for coating an article with said hydrophilic lubricious coating.

Claims

1. A hydrophilic lubricious coating composition comprising a non-toxic, cross-linked hydrophilic polyurethane which is insoluble in water, wherein said polyurethane is formed from the reaction on a surface to be coated, of a mixture comprising (a) a solution of an isocyanate terminated pre-polymer in a non-aqueous liquid, said pre-polymer being formed from a polyether or a polyester and an isocyanate, and a solution of a hydrophilic diol having a molecular weight of 5000-30,000 in a non-aqueous liquid, wherein the ratio, weight for weight, of the pre-polymer to the hydrophilic diol is 1:

1 to 1;

8.

2. A hydrophilic lubricious coating composition as claimed in claim 1, wherein the hydrophilic diol is polyethylene glycol or polypropylene glycol.

3. A hydrophilic lubricious coating composition as claimed in claim 1, wherein the hydrophilic diol has a molecular weight of 20,000.

4. A hydrophilic lubricious coating composition as claimed in claim 1, wherein the ratio, weight for weight, of pre-polymer to hydrophilic diol is 1:

2.

5. A hydrophilic lubricious coating composition as claimed in claim 1, wherein the concentration of the solution of the pre-polymer in the non-aqueous solvent is 2 to 20% be weight.

6. A hydrophilic lubricious coating composition as claimed in claim 5, wherein said non-aqueous solvent is tetrahydrofuran, methyl pyrrolidone or methylene chloride.

7. A hydrophilic lubricious coating composition as claimed in claim 1, wherein the concentration of the solution of the hydrophobic diol in the non-aqueous solvent is 2 to 20% by weight.

8. A hydrophilic lubricious coating composition as claimed in claim 7, wherein said non-aqueous solvent is dimethylformamide, dimethyl sulphoxide, dichloromethane or methyl pyrrolidone.

18. A method of coating the surface of an article, comprising applying the lubricious coating as claimed in claim 1 to the surface of the article by spraying or dip-coating and drying and curing the sprayed or coated article.

19. A method of coating the surface of an article as claimed in claim 18, wherein the article is dried and cured at a temperature of 60 to 100°

C., for a period of approximately 10 to 30 minutes.

20. An article coated by the method as claimed in claim 18.

9. A method for preparing a hydrophilic lubricious coating composition, comprising:

(I) Adding (a) a non-aqueous solution of an isocyanate terminated pre-polymer, said pre-polymer being formed from a polyether or polyester and an isocyanate, to (b) a non-aqueous solution of a hydrophilic diol having a molecular weight of 5000-30000, wherein the ratio, weight for weight, of the pre-polymer to the hydrophilic diol is 1;

1 to 1;

8; and

(II) Reacting, the two solutions (a) and (b) in (I) in a cross-linking reaction to produce a hydrophilic polyurethane which is insoluble in water.

10. A method for preparing a hydrophilic lubricious coating composition as claimed in claim 9, wherein the hydrophilic diol is polyethylene glycol or polypropylene glycol.

11. A method for preparing a hydrophilic lubricious coating composition as claimed in claim 9 or 10, wherein the hydrophilic diol has a molecular weight of 20,000.

12. A method for preparing a hydrophilic lubricious coating composition as claimed in claim 9, wherein the ratio, weight for weight, of pre-polymer to hydrophilic diol is 1.2.

13. A method for preparing a hydrophilic lubricious coating composition as claimed in claim 9, wherein the concentration of the solution of the pre-polymer in the non-aqueous solvent is 2 to 20% by weight.

14. A method for preparing a hydrophilic lubricious coating composition as claimed in claim 13, wherein said non-aqueous solvent is tetrahydrofuran, methyl pyrrolidone or methylene chloride.

15. A method for preparing a hydrophilic lubricious coating composition as claimed in claim 9, wherein the concentration of the hydrophilic diol in the non-aqueous solvent is 2 to 20% by weight.

16. A method for preparing a hydrophilic lubricious coating composition as claimed in claim 15, wherein said non-aqueous solvent is dimethylformamide, dimethyl sulphoxide, dichloromethane or methyl pyrrolidone.

17. A hydrophilic lubricious coating composition prepared by the method as claimed in claim 9.