Surgical probe for laparoscopy or intracavitary tumor localization

• US 6,021,341 A
• Filed: 03/05/1998
• Issued: 02/01/2000
• Est. Priority Date: 07/13/1995
• Status: Expired due to Fees

• Current Assignee: POL HI Tech SRL, Consiglio Nazionale Delle Ricerche (Repubblica Italiana)
• Original Assignee: POL HI Tech SRL, Consiglio Nazionale Delle Ricerche (Repubblica Italiana)
• Inventors: Scibilia, Guerrino, Soluri, Alessandro
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Assistant Examiner(s): Imam, Ali M.
• Application Number:
  US08/983,148
• Time in Patent Office: 698 Days
• Field of Search: 600/406, 600/407, 600/436, 600/431
• US Class Current: 600/407
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00

Abstract

The surgical probe according to the invention includes a collimator, made of lead or a high Z, atomic number metal; a scintillating crystal sensitive to gamma ray having an energy in the range from 30 KeV and 1 MeV; a light guide system; a photomultiplier; and electronics capable of integrating and converting analog signals to digital signals. The probe can be used in either intracavitary mode, or in laparoscopic mode, by putting the probe in a specific trocar. The apparatus may automatically subtract the background; and may provide visualization on a monitor. The probe can also include a flexible tip, in order to enlarge the field of view which the probe can be used to examine.

Claims

1. A laparoscopic surgical probe for localizing tumors and creating images of tumor-affected radiation emitting organs, said laparoscopic surgical probe comprising:

first components, including

a collimator member and

a scintillator means for receiving radiation rays emitted from the radiation emitting organs and converting the radiation rays into light signals;

a light transmission means to transmit the light signals generated by said first components to second components, including

a position sensitive light signal detector and

an electronic means for receiving said light signals and producing images of said radiation emitting organs, wherein

(a) said first components, said light transmission means and said second components form a unitary body probe;

(b) a converting means is provided, which are adapted to receive and convert radiation emitted from the radiation emitting organs in the energy range of 30 KeV to 1 MeV; and

(c) said collimator member has a section in the range between 6 mm and 15 mm, with a hole having 3 mm to 10 mm diameter, with a wall thickness in the range between 0.1 mm and 4 mm and with a length in the range between 5 mm and 50 mm.

2. A laparoscopic surgical probe according to claim 1, wherein said first components further comprise

a collimator member comprised of lead or another high Z metal which allows gamma ray passage through its hole only, and within a precise solid angle;

the collimator having an external diameter between 10 mm and 15 mm;

a scintillating crystal, sensitive to gamma rays having energy between 6 KeV and 1.3 MeV, emitting a blue or green light;

the crystal having an external diameter in the range between 6 mm and 10 mm;

a tungsten shield, to shield the scintillating crystal from gamma rays coming from lateral directions; and

wherein

said transmission means include;

a light guide system, optically coupled to the scintillating crystal on one side and to the photomultiplier on the other side, having a 8 mm cross section and being 200 mm in length;

a jacket made of an inert and sterilizable material, which has a cylindrical shape with a diameter in the range of 10 mm to 15 mm and 250 mm in length; and

wherein said second components include;

a container to house the photomultiplier;

a photomultiplier which turns the scintillation light pulse into an amplified electrical signal and which is a very compact one in which dynodes are stored in a cylindrical having a diameter in the range of 10 mm to 15 mm and a length in the range of 10 mm to 45 mm;

an electronic circuit which converts the analog signals to digital ones, giving in real time a measurement of the integrated charge, which is proportional to the energy of the incident particle, and a measurement of the number of the gamma rays, interacting according to photoelectric effect in the scintillating crystal, as a function of time or probe position.

3. A laparoscopic surgical probe according to claim 2, wherein said scintillator means comprise a matrix of scintillating crystals, each crystal having a cross section in the range between (0.5×

0.5) square mm and (2×

2) square mm and being optically separated from the other ones, and the separation between the crystals having a thickness in the range from 3 microns to 0.5 mm.

4. A laparoscopic surgical probe according to claim 3, wherein said scintillating crystal is selected from the group consisting of CsI (Tl), NaI (Tl), BGO, and LSO crystals.

5. A laparoscopic surgical probe according to claim 4, wherein said light guide is made of a material having a refractive index between 1.41 and 1.62.

6. A laparoscopic surgical probe according to claim 1, wherein the scintillating crystal is directly optically coupled to the photomultiplier.

7. A laparoscopic surgical probe according to claim 1, wherein the scintillating sensitive detector and the light guide are comprised of a central part to collect the signal coming from the main source and of a peripherical part to collect the signal coming from the background, the central part being made of a crystal coupled to a light guide or an optical fiber of similar cross section, while the surrounding part is comprised of a few crystals coupled to light guides or optical fibers having a smaller cross section than the central part ones, and where both the individual scintillating crystals and the light guides or optical fibers are optically separated from each other.

8. A laparoscopic surgical probe according to claim 1, wherein the light guide is comprised of an optical fiber bundle, having a cross section which, on one side, is equal to the total surface of the scintillating crystal, and, on the other side, is similar to the active area of the photomultiplier without formation of dead zones, and said fibers have a square or circular or hexagonal cross section and a diameter or side-side dimension ranging from 0.3 mm to 2 mm.

9. A laparoscopic surgical probe according to claim 1, wherein the plastic light guides or optical fibers are substituted by light guides or optical fibers made of an inorganic material such as silica, quartz, etc.

10. A laparoscopic surgical probe according to claim 1, wherein the optical fiber guided signal is collected by a photomultiplier with an 8 mm diameter active window and is responsive to the single photon emission.

11. A laparoscopic surgical probe according to claim 1, said position sensitive photomultiplier has a metal channel dynode system to improve the spacial resolution up to 2 mm.

12. A laparoscopic surgical probe according to claim 1, wherein the photomultiplier is replaced by a solid state detector, with pixels of from 0.2×

0.2 mm to 1×

1 mm, which reads light photons, and which indicates the position and the energy absorbed by the scintillating crystal during interaction with the gamma ray.

13. A laparoscopic surgical probe according to claim 12, wherein an electronic circuit converts the photomultiplier analog signals into visible or voiced digital signals.

14. A laparoscopic surgical probe according to claim 13, wherein the visible and voiced digital signals are proportional to the detected gamma ray intensity, thus indicating the position of the highest radiotracer concentration.

15. A laparoscopic surgical probe according to claim 14, wherein the signals are integrated and, via software, transformed into a real time imaging, to give images showing gamma ray emission distributions with a spatial resolution up to 2 mm.

16. A laparoscopic surgical probe according to claim 1, wherein the probe is jacketed with inert and sterilizable material and is introduced into a trocar having a 12 mm minimum internal diameter.

17. A laparoscopic surgical probe according to claim 16, wherein the probe introduced into the trocar is flexible so that the tip portion can be bent via an externally guided knob system to scan a larger area.

18. A laparoscopic surgical probe according to claim 17, wherein the overall length is 35 cm and the portion introduced into the trocar is from 10 cm to 30 cm long, and from 6 mm to 22 mm in diameter, and the external portion is 100 mm long and 30 mm in diameter.

19. A laparoscopic surgical probe according to claim 1, wherein, via dedicated software, a graphic program handles the event data visualization on a personal computer monitor and the tumor site localization is based on the tumor to background counting ratio, thus allowing the graphical visualization of the count numbers as a function of time.

20. A laparoscopic surgical probe according to claim 19, wherein the dedicated software graphic program carries out the visualization of the incident gamma-ray energy spectrum, thus allowing, on one end, the detector calibration according to the used radioactive tracer, and, on the other end, the energy selection window, and where acquisition program selects events which enter directly the detector without scattering, thus having an energy characteristic of the photoelectric peak, while rejecting events scattered by Compton effects and having an energy lower than the photoelectric peak.

21. A laparoscopic surgical probe according to claim 20, wherein the gamma ray intensity and the maximum intensity position are visualized via a luminous color scale and a voiced system both of which are proportional to the gamma ray intensity.

22. A laparoscopic surgical probe to according to claim 21, wherein the intensity visualization system is replaced by a real time imaging to see all the investigated area by showing the light-color intensity proportionally to the gamma ray intensity with a spacial resolution up to 2 mm.