Tumor treatment

• US 6,022,308 A
• Filed: 03/14/1997
• Issued: 02/08/2000
• Est. Priority Date: 06/14/1991
• Status: Expired due to Term

• Current Assignee: Cytyc Corporation (Hologic Incorporated)
• Original Assignee: Proxima Therapeutics, Inc.
• Inventors: Williams, Jeffery A.
• Primary Examiner(s): Lacyk, John P.
• Application Number:
  US08/818,966
• Time in Patent Office: 1,061 Days
• Field of Search: 600/1-8
• US Class Current: 600/2
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61M 2025/1013 with concentrically mounted balloons, e.g. being independently inflatable
• CPC Class Codes: A61M 2039/0211 with multiple chambers in a single site
• CPC Class Codes: A61M 2205/32 with radio-opaque indicia
• CPC Class Codes: A61M 2210/0687 Skull, cranium
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 2230/005 Parameter used as control input for the apparatus
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters
• CPC Class Codes: A61M 27/006 Cerebrospinal drainage; Accessories therefor, e.g. valves
• CPC Class Codes: A61M 39/0208 Subcutaneous access sites for injecting or removing fluids transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276
• CPC Class Codes: A61M 39/0247 Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053
• CPC Class Codes: A61M 5/427 Locating point where body is to be pierced, e.g. vein location means using ultrasonic waves, injection site templates
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals
• CPC Class Codes: A61N 1/403 for thermotherapy, e.g. hyperthermia
• CPC Class Codes: A61N 2005/1021 Radioactive fluid
• CPC Class Codes: A61N 5/1014 Intracavitary radiation therapy
• CPC Class Codes: A61N 5/1015 Treatment of resected cavities created by surgery, e.g. lumpectomy
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A completely implantable apparatus is provided for treatment of tissue surrounding a cavity left by surgical removal of a brain tumor. The apparatus includes an inflatable balloon constructed for placement in the cavity. A subcutaneously implantable treatment fluid receptacle is provided for receiving a transdermal injection of a treatment fluid. A catheter connects the receptacle to the inflatable balloon. Various embodiments provide for simultaneous application of heat therapy and/or radiation therapy and/or chemotherapy to the remaining tissue surrounding the cavity from which the tumor was removed.

Claims

1. A treatment fluid for treatment of a tumor in a patient, comprising:

a carrier fluid;

a ferromagnetic material; and

a radioactive material, said ferromagnetic material and said radioactive material being mixed together in said carrier fluid,

wherein said ferromagnetic material is present in an amount effective to heat said treatment fluid in response to radio frequency electromagnetic energy.

2. The treatment fluid of claim 1, wherein said ferromagnetic material is iron oxide.

3. The treatment fluid of claim 1, wherein said radioactive material is in solution in said carrier fluid.

4. The treatment fluid of claim 1, wherein said radioactive material comprises a radioisotope selected from the group consisting of 90-Yttrium, 198-Gold, 32-Phosphorus, 125-Iodine, and 131-Iodine.

5. A treatment fluid for treatment of a tumor in a patient, comprising:

a carrier fluid;

a ferromagnetic material; and

a radioactive material;

said ferromagnetic material and said radioactive material being mixed together in said carrier fluid,

wherein said radioactive material is in solution in said carrier fluid.

6. A method for providing simultaneous heat treatment and radiation treatment of a tumor in a living patient, the method comprising:

placing an inflatable treatment device in a cavity adjacent the tumor;

inflating the inflatable treatment device with a treatment fluid comprising a carrier fluid, a ferromagnetic material, and a radioactive material; and

applying radio frequency electromagnetic energy to the treatment fluid, such that the treatment fluid is heated and simultaneous heat treatment and radiation treatment of the tumor is provided.

7. The method of claim 6, wherein the method comprises, prior to the placing step, the step of surgically removing at least a portion of the tumor, thereby creating a cavity in the patient'"'"'s remaining tissue.

8. The method of claim 6, wherein said ferromagnetic material and said radioactive material are mixed together in said carrier fluid, and said radioactive material is in solution in said carrier fluid.

9. The method of claim 6, wherein the ferromagnetic material is iron oxide.

10. The method of claim 6, wherein the radioactive material comprises a radioisotope selected from the group consisting of 90-Yttrium, 198-Gold, 32-Phosphorus, 125-Iodine, and 131-Iodine.