Antimicrobial nail coating composition

• US 6,022,549 A
• Filed: 01/06/1999
• Issued: 02/08/2000
• Est. Priority Date: 12/18/1997
• Status: Expired due to Term

• Current Assignee: Pacific World Corporation (PWC Holding Corp.)
• Original Assignee: Woodward Laboratories, Inc.
• Inventors: Dyer, David L.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): HOWARD, SHARON LEE
• Application Number:
  US09/226,414
• Time in Patent Office: 398 Days
• Field of Search: 424/401, 424/61, 424/404, 424/405
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/51 Chelating agents
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61Q 3/02 Nail coatings

Abstract

Antimicrobial nail coating compositions, and methods for treating and preventing microbial infections of the nail area, are provided. The antimicrobial nail coating compositions can be used to treat and/or prevent infections caused by microbes including bacteria, molds, spores, viruses and fungi, while providing a nail coating having acceptable handling and esthetic qualities. The compositions can include alcohol-containing solvents, and, as antimicrobial agents, quaternary amines or phenols.

Claims

1. A non-aqueous antimicrobial nail coating composition comprising:

(a) an antimicrobial agent comprising a phenol;

(b) at least one film-forming polymer or resin; and

(c) an organic solvent;

wherein said phenol is substantially separate from the film-forming polymer or resin, wherein the phenol is capable of leaching from said composition following transition of the nail coating from a liquid to a solid state upon application, wherein the phenol retains its antimicrobial activity following the transition of the nail coating from a liquid to a solid state upon application, and wherein the phenol is capable of resisting inactivation by isopropyl alcohol during storage.

2. The composition of claim 1 wherein the phenol is present in an amount of from 0.05 percent to about 5 percent by weight.

3. The composition of claim 2 wherein said phenol is selected from the group consisting of resorcinol, hexylresorcinol, hexachlorophene, parabens, thymol, chlorothymol, parachlorometaxylenol, orthophenylphenol, p-tertiary butylphenol, p-tertiaryamylphenol, o-benzylphenyl-p-chlorophenol, parachlorophenol, camphorated parachlorophenol, tetrabromomethylphenol, 2,6-dimethyl-4-chlorophenol, and parachlorometaxylenol.

8. The composition of claim 1, further comprising from about 0.01 weight percent to about 20 weight percent of tea tree oil, terpinen-4-ol, alpha terpineol, alpha pinene, or combinations thereof.

4. A non-aqueous antimicrobial nail coating composition comprising:

(a) from about 5 percent to about 65 percent by weight of a film-forming polymer;

(b) from about 10 percent to about 80 percent by weight of a solvent; and

(c) from about 0.05 percent to about 5 percent by weight of an antimicrobial agent, wherein said antimicrobial agent comprises a phenol;

wherein the phenol is substantially separate from the film-forming polymer or resin, wherein the phenol is capable of leaching from said composition following transition of the nail coating from a liquid to a solid state upon application, wherein the phenol retains its antimicrobial activity following the transition of the nail coating from a liquid to a solid state upon application, and wherein the phenol is capable of resisting inactivation by isopropyl alcohol during storage.

5. The composition of claim 4 wherein the film-forming polymer comprises at least one of a cellulose derivative or an acrylic polymer.

6. The composition of claim 4 wherein the nail coating composition further comprises from about 1 percent to about 80 percent by weight of a resin.

7. The composition of claim 6 wherein said resin is a shellac, pontianak, acrylic copolymer, polyvinyl acetate, butyrate, or arylsulfonamide-formaldehyde resin.

11. The composition of claim 4, further comprising from about 0.01 weight percent to about 20 weight percent of tea tree oil, terpinen-4-ol, alpha terpineol, alpha pinene, or combinations thereof.

12. The composition of claim 4 wherein the phenol is present in an amount of from 0.05 percent to about 5 percent by weight.

9. A non-aqueous antimicrobial nail coating composition comprising:

(a) from about 1 percent to about 80 percent by weight of a resin;

(b) from about 10 percent to about 80 percent by weight of a solvent; and

(c) from about 0.05 percent to about 5 percent by weight of an antimicrobial agent, wherein said antimicrobial agent comprises a phenol;

wherein the phenol is substantially separate from the film-forming polymer or resin, wherein the phenol is capable of leaching from said composition following transition of the nail coating from a liquid to a solid state upon application, wherein the phenol retains its antimicrobial activity following the transition of the nail coating from a liquid to a solid state upon application, and wherein the phenol is capable of resisting inactivation by isopropyl alcohol during storage.

10. The composition of claim 9, further comprising from about 0.001 weight percent to about 2 weight percent of one or more lipids.

13. The composition of claim 9 wherein the phenol is present in an amount of from 0.05 percent to about 5 percent by weight.

14. A non-aqueous antimicrobial nail coating composition comprising:

(a) from about 5 percent to about 65 percent by weight of a film-forming polymer;

(b) from about 10 percent to about 80 percent by weight of an organic solvent; and

(c) from about 0.05 percent to about 5 percent by weight of an antimicrobial agent comprising a phenol;

wherein said antimicrobial nail coating composition is prepared by first blending the film-forming polymer with the organic solvent to prepare a pre-blend and subsequently mixing the phenol, as a separate component, with the pre-blend.

15. The composition of claim 14 wherein the phenol is present in an amount of from 0.05 percent to about 5 percent by weight.

16. A non-aqueous antimicrobial nail coating composition comprising:

(a) from about 1 percent to about 80 percent by weight of a resin;

(b) from about 10 percent to about 80 percent by weight of an organic solvent; and

(c) from about 0.05 percent to about 5 percent by weight of an antimicrobial agent comprising a phenol;

wherein said antimicrobial nail coating composition is prepared by first blending the film-forming polymer with the organic solvent to prepare a pre-blend and subsequently mixing the phenol, as a separate component, with the pre-blend.

17. The composition of claim 16 wherein the phenol is present in an amount of from 0.05 percent to about 5 percent by weight.