Antimicrobial composition

• US 6,022,551 A
• Filed: 01/20/1998
• Issued: 02/08/2000
• Est. Priority Date: 01/20/1998
• Status: Expired due to Term

• Current Assignee: Schulke & Mayr GmbH
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Jampani, Hanuman B., Newman, Jerry L.
• Primary Examiner(s): Dodson, Shelley A.
• Assistant Examiner(s): Lamm, Marina
• Application Number:
  US09/009,596
• Time in Patent Office: 749 Days
• Field of Search: 424/401, 424/405, 514/642, 514/758, 514/358, 514/724
• US Class Current: 424/405
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 31/16 with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 37/10 Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 47/28 Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< isoureas, isothioureas A01N47/42
• CPC Class Codes: A01N 57/12 containing acyclic or cycloaliphatic radicals
• CPC Class Codes: A01N 65/00 Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof containing compounds of determined constitution A01N27/00 - A01N59/00
• CPC Class Codes: A01N 65/22 Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
• CPC Class Codes: A01N 65/28 Myrtaceae [Myrtle family], e.g. teatree or clove
• CPC Class Codes: A01N 65/44 Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/09 having two or more such linkages
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 36/61 Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
• CPC Class Codes: A61K 36/899 Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/9789 : Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 : Liliopsida [monocotyledons]
• CPC Class Codes: A61P 1/00 : Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 17/00 : Drugs for dermatological disorders
• CPC Class Codes: A61P 31/00 : Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/02 : Local antiseptics
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 31/10 : Antimycotics
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin

Abstract

A rapidly acting antimicrobial alcohol-containing composition and method of using the composition to disinfect surfaces, such as the hands is disclosed.

Claims

1. An antimicrobial composition comprising:

a) from about 55 to about 90 percent by volume alcohol;

b) an effective amount of an antimicrobial material selected from the group consisting of phenoxy ethanol, benzalkonium chloride, benzethonium chloride, cocophosphatidyl-dimonium chloride and mixtures thereof;

c) a thickener consisting of from about 0.4 to about 0.7 weight percent of a carbomer polymer which is a copolymer having a major portion comprising a monoolefinically unsaturated carboxylic acid monomer or its anhydride of 3 to 6 carbon atoms; and

a minor portion of a long chain acrylate or methacrylate ester monomer;

said antimicrobial composition having a viscosity of from about 9,000 to about 22,000 centipoise as measured at 25°

C.

2. The composition of claim 1 wherein the alcohol is selected from the group consisting of ethyl alcohol, iso-propyl alcohol, n-propyl alcohol and mixtures thereof.

3. The composition of claim 1 wherein phenoxy ethanol is present in amount from about 0.25 to about 5.0 percent by weight;

benazalkonium chloride is present in the amount from about 0.02 to about 1.0 percent by weight; and

cocophosphatidyl-dimonium chloride is present in the amount from about 0.01 to about 1.0 percent by weight.

4. The composition of claim 1 which additionally contains an effective amount of diazolidinyl urea and 3-Iodo-propynylbutylcarbamate.

5. The composition of claim 4 wherein the total amount of diazolidinyl urea and 3-Iodo-propynylbutylcarbamate is from about 0.05 to about 0.5 percent by weight.

6. The composition of claim 4 which additionally contains an effective amount of methyl paraben;

propyl paraben; and

propylene glycol.

7. The composition of claim 6 wherein the total amount of diazolindinyl urea;

methyl paraben;

propyl paraben; and

propylene glycol is from about 0.05 to about 0.5 percent by weight.

8. The composition of claim 1 which additionally contains an effective amount of cocamidopropyl phosphatidyl dimonium chloride.

9. The composition of claim 8 wherein the amount of cocamidopropyl phosphatidyl dimonium chloride is from about 0.01 to about 1.0 percent by weight.

10. A method of disinfecting a substrate comprising applying an effective amount of the antimicrobial composition of claim 1 to a substrate.

11. The method of claim 10 wherein the substrate is the hand.

12. A method for controlling Staphylococcus aureaus (MRSA) comprising topical administration to a substrate an anti-microbially effective amount of the composition of claim 1.

13. A method for controlling Staphylococcus aureaus (MRSA) comprising topical administration to a substrate an anti-microbially effective amount of the composition according to claim 2.

14. A method for controlling Serratia marcescens ATCC 14756 comprising topical administration to a substrate an anti-microbially effective amount of the composition of claim 1.

15. A method for providing moisture to the skin comprising the application of an effective amount of the composition of claim 1 to the skin.

16. The method of claim 15 wherein the amount of composition applied to the skin is from about 0.5 to about 10 milliliters.

17. The composition of claim 1 which additionally contains an effective amount of an essential oil selected from the group consisting of Australian tea tree oil, lemongrass oil, thyme oil, lavender oil, and clove oil.

18. The composition of claim 2 which additionally contains an effective amount of an essential oil selected from the group consisting of Australian tea tree oil, lemongrass oil, thyme oil, lavender oil, and clove oil.

19. The composition of claim 1 which additionally contains an effective amount of octanoyl collagenic acid and cetyl pyridium chloride.

20. An antimicrobial composition consisting essentially of:

a) from about 55 to about 90 percent by volume alcohol;

b) an effective amount of an antimicrobial material selected from the group consisting of phenoxy ethanol, benzalkonium chloride, benzethonium chloride and cocophosphatidyl-dimonium chloride;

c) from about 0.4 to about 0.7 weight percent of a carbomer polymer, the carbomer polymer is a copolymer having a major portion comprising a monoolefinically unsaturated carboxylic acid monomer or its anhydride of 3 to 6 carbon atoms; and

a minor portion of a long chain acrylate or methacrylate ester monomer;

said antimicrobial composition having a viscosity of from about 9,000 to about 22,000 centipoise as measured at 25°

C.