Method of making a blood-compatible antimicrobial surface

• US 6,022,553 A
• Filed: 04/21/1998
• Issued: 02/08/2000
• Est. Priority Date: 04/21/1997
• Status: Expired due to Fees

• Current Assignee: Degussa-Huels Aktiengesellschaft (Rag-Stiftung)
• Original Assignee: Huels Aktiengesellschaft (Rag-Stiftung)
• Inventors: Lorenz, Guenter, Anders, Christine, Hoecker, Hartwig
• Primary Examiner(s): DUDASH, DIANA L
• Application Number:
  US09/063,412
• Time in Patent Office: 658 Days
• Field of Search: 427/536, 427/538, 427/2.1, 427/2.12, 427/2.13, 427/2.24, 427/2.25, 427/2.3, 427/535, 427/569, 427/532, 427/299, 427/377, 427/387, 427/444, 427/2.28, 623/1, 623/2, 623/11, 351/160 H, 424/411, 424/404, 424/422, 424/423, 424/412, 424/429, 424/364, 604/265, 428/411.1, 428/409
• US Class Current: 424/411
• CPC Class Codes: A01N 59/02 Sulfur; Selenium; Tellurium; Compounds thereof
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
• CPC Class Codes: Y10T 428/31504 Composite [nonstructural laminate]

Abstract

A method for making antimicrobial, blood-compatible surfaces is provided, articles having surfaces made by this method, and the use of these articles in fields where controlling the spread of microbes and blood-compatibility are important. Such fields include the medical field, where it is critical to eliminate infection causing microbes and reduce the number of dangerous blood clots in patients.

Claims

1. A method for forming a bacteria-repelling and blood-compatible modified surface on a substrate, comprising the sequential steps of:

a. activating the surface of a substrate;

b. grafting the resulting activated surface of the substrate with a hydrophilic monomer, and

c. subjecting the resulting grafted substrate to an SO₂ plasma treatment,

whereby bacterial adhesion and blood platelet adhesion to said modified surface after exposure to said plasma treatment is less than prior to said plasma treatment.

2. The method as claimed in claim 1, wherein the number of platelets that adhere to said surface after said exposure to said plasma is reduced to 50% or less of the number of platelets that adhere to the surface prior to exposure to said plasma.

3. The method as claimed in claim 1, wherein the number of platelets that adhere to said surface after said exposure to said plasma is reduced to 60% or less of the number of platelets that adhere to the surface prior to exposure to said plasma.

4. The method as claimed in claim 1, wherein the number of platelets that are activated on said surface after said exposure to said plasma is reduced to 40% or less of the number of platelets that are activated on the surface prior to exposure to said plasma.

5. The method as claimed in claim 1, wherein the number of platelets that are activated on said surface after said exposure to said plasma is reduced to 50% or less of the number of platelets that are activated on the surface prior to exposure to said plasma.

6. The method as claimed in claim 1, wherein the SO₂ gas partial pressure in said plasma is 10 to 100 Pa.

7. The method as claimed in claim 1, wherein the SO₂ gas partial pressure in said plasma is 10 to 40 Pa.

8. The method as claimed in claim 1, wherein the SO₂ gas is excited by microwave energy to form said plasma.

9. The method as claimed in claim 1, wherein said surface is exposed to said plasma for 1 second to 10 minutes.

10. The method as claimed in claim 1, wherein said surface is exposed to said plasma for 10 seconds to 4 minutes.

11. The method as claimed in claim 1 wherein the number of microbes that adhere to said surface after said exposure to said plasma is reduced by 99% or more compared to the number of microbes that adhere to the surface prior to exposure to said plasma.

12. An article made by the method of claim 11.

13. The article according to claim 12, wherein said article is selected from the group consisting of food handling articles, biomedical articles, and waste treatment articles.

14. The article according to claim 12, wherein said article is selected from the group consisting of seats, telephones, doorknobs, handles, latches, railings, sinks, and toilets.

15. The article according to claim 12, wherein said article is selected from the group consisting of catheters, stents, dialysis tubes, catheter tubes, drainage tubes, artificial blood vessels, cardiac valves, artificial limbs, dental prostheses, contact lenses, and surgical suture material.

16. The article according to claim 12, wherein said article is selected from the group consisting of utensils, glasses, bowls, cutting surfaces, and counter tops.

17. The method as claimed in claim 1, wherein said hydrophilic monomer is acrylic acid, methacrylic acid, diethylene glycol methacrylate, polyethylene glycol methacrylate, 2-hyroxyethyl acrylate, 2-hydroxyethyl acrylate or 4-hydroxybutyl acrylate.

18. The method as claimed in claim 1, wherein the number of microbes that adhere to said surface after said exposure to said plasma is reduced by 80% or more compared to the number of microbes that adhere to the surface prior to exposure to said plasma.

19. The method as claimed in claim 18, wherein said microbes are selected from the group consisting of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Kelbsiella pneumoniae.

20. The method according to claim 1, wherein said substrate surface is selected from the group consisting of polyolefins, halogen-containing polymers, polymers and copolymers of vinylaromatic monomers, polycondensates, polyamides, polyether block amides, polyurethanes, polyethers, polycarbonates, polysulfones, polyetherketones, polyesteramides and -imides, polyacrylonitrile, polyacrylates, and polymethacrylates.