Heterocyclyloxybenzoylguanidines

• US 6,022,883 A
• Filed: 06/20/1995
• Issued: 02/08/2000
• Est. Priority Date: 06/20/1994
• Status: Expired due to Fees

• Current Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Original Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Inventors: Minck, Klaus Otto, Beier, Norbert, Gericke, Rolf, Dorsch, Dieter, Baumgarth, Manfred
• Primary Examiner(s): Ford, John M.
• Application Number:
  US08/492,619
• Time in Patent Office: 1,694 Days
• Field of Search: 546/300, 514/351
• US Class Current: 514/351
• CPC Class Codes: A61P 9/06 Antiarrhythmics
• CPC Class Codes: A61P 9/08 Vasodilators for multiple indications
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 213/643 2-Phenoxypyridines; Derivatives thereof
• CPC Class Codes: C07D 213/65 attached in position 3 or 5
• CPC Class Codes: C07D 213/68 attached in position 4
• CPC Class Codes: C07D 233/70 One oxygen atom
• CPC Class Codes: C07D 237/14 Oxygen atoms
• CPC Class Codes: C07D 237/16 Two oxygen atoms
• CPC Class Codes: C07D 239/34 One oxygen atom
• CPC Class Codes: C07D 241/18 Oxygen or sulfur atoms

Abstract

Heterocyclyloxybenzoylguanidines of the formula I ##STR1## in which R¹, R² and Het have the given meanings, and also the pharmaceutically acceptable salts thereof, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na⁺ /H⁺ antiporter.

Claims

1. Heterocyclyloxybenzoylguanidines of the formula I ##STR6## in which R¹ is A

R² is SO₂ A or NO₂,

A is alkyl having 1 to 6 C atoms,

Het is pyridin-3-yl or 5-Cl-pyridin-3-yl,

and the physiologically acceptable salts thereof.

2. Pharmaceutical preparation which comprises a compound selected from the group consisting of compounds of the general formula I according to claim 1 and pharmaceutically acceptable salts thereof.