Method and device for noninvasive measurements of concentrations of blood components

• US 6,026,314 A
• Filed: 09/08/1998
• Issued: 02/15/2000
• Est. Priority Date: 09/05/1997
• Status: Expired due to Term

• Current Assignee: Samsung Electronics Co. Ltd.
• Original Assignee: Samsung Electronics Co. Ltd.
• Inventors: Yoon, Gil-won, Jeon, Kye-jin, Amerov, Airat K., Kim, Yoen-joo
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/149,219
• Time in Patent Office: 525 Days
• Field of Search: 600/310, 600/316, 600/322, 600/323, 600/326, 600/328, 600/473, 600/476
• US Class Current: 600/322
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

A method and device for noninvasive measurement of blood component concentrations utilizes pulsed polychromatic light source emitting, light in the near infrared range 800-1850 nm. The light is back scattered from or transmitted through a part of a patient'"'"'s body. Back scattered light from blood-containing tissues and blood vessels has information on blood component concentrations. That light is collected to avoid the surface reflection from the skin surface and to minimize the effects of changes in the scattering background. The concentrations of blood components are calculated from the spectral analysis based on selected wavelengths by a defined algorithm. A microprocessor calculates and determines the blood component concentrations by comparing a ratio with a calibration curve stored in a memory of the microprocessor. The calculated concentration values are displayed on a display.

Claims

1. A method for measuring concentrations of blood components and analytes including at least one of glucose, cholesterol, albumin, hemoglobin, alcohol or drugs, the method comprising the steps of:

(a) irradiating near infrared light onto skin of a subject containing blood-containing tissues and blood vessels;

(b) receiving the near infrared light containing information on the blood component concentration, back scattered from or transmitted through the blood-containing tissues and blood vessels;

(c) selectively outputting the light of at least three wavelengths from the received near infrared light;

(d) converting the light of the at least three outputted wavelengths electrical signals, respectively; and

(e) computing the blood component concentration using the electrical signals,

wherein in step (c), assuming that A_ic, i=1, 2,. . . , n, are absorption values of light of n wavelengths for the blood component being measured, the requirements for selection of the wavelengths are;

(1) A_1c is the maximum among A_1c, A_2c, A_3c,. . . , A_nc, and A_2c, A_3c, . . . , A_nc are negligible when compared to A_1c ; and

(2) for other components, with the exception of the blood component being measured, the relation ##EQU14## is satisfied, where A_ij is absorption value of wavelength i for blood component j, and n is the number of selected wavelengths.

2. The method according to claim 1, wherein in step (a), the near infrared light in the range of 800-1850 nm is simultaneously irradiated on the blood-containing tissues and blood vessels through skin during a predetermined time pulse interval.

3. The method according to claim 1, wherein step (a) of irradiating uses irradiation channels and step (b) of receiving the near infrared light uses reception channels that are spatially separated from the irradiation channels to avoid direct reflection from the skin surface.

4. The method according to claim 1, wherein in step (c) assuming that A_ic, i=1, 2, 3, are absorption values of light of three wavelengths 1, 2, and 3 for the blood component being measured the requirements for selection of the wavelengths are:

(1) A_1c is the maximum among A_1c, A_2c, A_3c, and A_2c, A_3c are negligible when compared to A_1c ; and

(2) for other components, with the exception of the blood component being measured, the relation A_ij -A_2j ≈

A_2j -A_3j is satisfied, where A_ij is absorption value of wavelength i for blood component j.

5. The method according to claim 4, wherein the wavelengths 1, 2 and 3 are 1625 nm, 1364 nm and 1200 nm, respectively.

6. The method according to claim 1, wherein in step (c), assuming that A_ic, i=1, 2, 3, 4, are absorption values of light of four wavelengths 1, 2, 3, and 4 for the blood component being measured the requirements for selection of the wavelengths are:

(1) A_1c is the maximum among A_1c, A_2c, A_3c, A_4c, and A_2c, A_3c, and A_4c are negligible when compared to A_1c ; and

(2) for other components, with the exception of the blood component being measured, the relation A_1j -A_2j ≈

A_2j +A_3j- 2A_4j is satisfied, where A_ij is absorption value of wavelength i for blood component j.

7. The method according to claim 6, wherein the wavelengths 1, 2, 3 and 4 are 1625 nm, 1364 nm, 1200 nm and 1300 nm, respectively.

8. The method according to claim 1, wherein the steps (a) through (e) are repeated to determine concentrations of other blood components using wavelength sets corresponding to a respective optimal wavelength set for each of the other blood component and applying all of the determined concentrations to make a more accurate determination of finally determined blood component concentrations.

9. The method according to claim 8, wherein the steps (a) through (e) are repeated using a wavelength set of 1164 nm, 1225 nm, 1300 nm for determining hemoglobin concentration and thereafter using a first wavelength set (1718 nm, 1364 nm, 1300 nm, 1164 nm) and a second wavelength set (1739 nm, 1364 nm, 1300 nm, 1164 nm) for determining cholesterol and albumin concentrations, respectively, using the determined hemoglobin concentration and finally using a third wavelength set (1625 nm, 1364 nm, 1225 nm and 1164 nm) for determining blood glucose concentration using the determined concentrations of hemoglobin, cholesterol and albumin.

10. The method according to claim 1, wherein step (e) of computing the blood component concentration includes using a chemometric analysis applied to the calculation of to calculate the blood component concentrations.

11. A device for measuring blood component concentrations comprising:

means for irradiating near infrared light onto skin of a subject containing blood-containing tissues and blood vessels;

means for receiving the near infrared light containing information on the blood component concentration, back scattered from or transmitted through blood-containing tissues and blood vessels;

means for selectively outputting the light of at least three wavelengths from the received near infrared light;

means for converting the light of the at least three output wavelengths into electrical signals, respectively, and

means for computing the blood component concentration using the electrical signals;

wherein assuming that A_ic, i=1, 2 . . . , n, are absorption values of light of n wavelengths for the blood component being measured the requirements for wavelengths selection are;

(1) A_1c is the maximum among A_ic, A_2c, A_3c, . . . , A_nc, and A_2c, A_3c, . . . , A_nc are negligible when compared to A_1c, and

(2) for other components, with the exception of the blood component being measured, the relation ##EQU15## is satisfied, where A_ij is absorption value of wavelength i for blood component j and n is the number of selected wavelengths.

12. The device according to claim 11,

wherein the computing means calculates a ratio D of the electrical signals, represented by the following formula ##EQU16## compares the calculated ratio D with a predetermined calibration curve, and calculates the blood component from the comparison of the calculated ratio D with the predetermined calibration curve, wherein T_i =J_i /J_io where i=1, 2, . . . , n, J_i and J_io are intensities of the back scattered or transmitted light and incident light corresponding to the wavelength i, respectively.

13. The device according to claim 11, wherein the irradiating means is a flash lamp providing simultaneous irradiation of the blood-containing tissues and blood vessels through skin during a predetermined time pulse interval.

14. The device according to claim 11, wherein the irradiating means is a light emitting diode.

15. The device according to claim 11, wherein the irradiating means is a laser diode.

16. The device according to claim 11, wherein the receiving means includes spatially separated right angle prisms oriented to avoid surface reflection from the skin.

17. The device according to claim 11, wherein the receiving means includes optical fiber bundles.

18. The device according to claim 11, wherein the receiving means and the selective outputting means include dispersion prisms.

19. A method for measuring concentrations of blood components and analytes including at least one of glucose, cholesterol, albumin, hemoglobin, alcohol and drugs, the method comprising the steps of:

(a) irradiating near infrared light onto skin of a subject containing blood-containing tissues and blood vessels;

(b) receiving the near infrared light containing information on the blood component concentration, back scattered from or transmitted through blood-containing tissues and blood vessels;

(c) selectively outputting the light of at least three wavelengths from the received near infrared light;

(d) converting the light of the at least three output wavelengths into electrical signals, respectively;

(e) calculating a ratio D using the electrical signals, represented by the following formula ##EQU17## wherein T_i =J_i /J_io, where i=1, 2, . . . , n, J_i and J_io are intensities of the back scattered or transmitted light and incident light, corresponding to the wavelength i, respectively; and

(f) calculating blood component concentration using the calculated ratio D.

20. The method according to claim 19, wherein step (f) is performed by comparing the calculated ratio D with a predetermined calibration curve.

21. The method according to claim 19, wherein in step (c) the light of three wavelengths from the near infrared light is selectively output and in step (d) the light of three wavelengths output is converted into the electrical signals, respectively, and in step (e) the ratio D using the electrical signals, represented by the following formula D=(log 1/T₁ -log 1/T₂)/(log 1/T₂ -log 1/T₃), wherein T_i =J_i /J_io, where i=1, 2, 3, J_i and J_io are intensities of the back scattered or transmitted light and incident light, corresponding to the wavelength i, respectively.

22. The method according to claim 19, wherein in step (c) the light of four wavelengths from the near infrared light is selectively output and in step (d) the light of four wavelengths output is converted into the electrical signals, respectively, and in step (e) the ratio D using the electrical signals, represented by the following formula D=(log 1/T₁, -log 1/T₂)/(log 1/T₂ +log 1/T₃ -2log 1/T₄), wherein T_i =J_i /J_io, where i=1, 2, 3, 4, J_i and J_io are intensities of the back scattered or transmitted light and incident light, corresponding to the wavelength i, respectively.

23. A device for measuring blood component concentrations comprising:

means for irradiating near infrared light onto skin of a subject containing blood-containing tissues and blood vessels;

means for receiving the near infrared light containing information on the blood component concentration, back scattered from or transmitted through blood-containing tissues and blood vessels;

means for selectively outputting the light of at least three wavelengths from the received near infrared light;

means for converting the light of the at least three output wavelengths into electrical signals, respectively; and

means for computing the blood component concentration using the electrical signals, wherein the means for irradiating includes irradiation channels and the means for receiving includes reception channels, the irradiation channels and the reception channels being spatially separated and said receiving means is spaced from an irradiation point by a predetermined distance.

24. The device according to claim 23, wherein the predetermined distance is about 2-5 mm.