Blood pressure estimating apparatus and method

• US 6,027,455 A
• Filed: 05/29/1998
• Issued: 02/22/2000
• Est. Priority Date: 05/12/1998
• Status: Expired due to Term

• Current Assignee: Omron Healthcare Company Limited (Omron Corporation)
• Original Assignee: Colin Corporation (Fukuda Denshi Company Limited)
• Inventors: Kawaguchi, Keizoh, Inukai, Hidekatsu, Yokozeki, Akihiro
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US09/086,750
• Time in Patent Office: 634 Days
• Field of Search: 600/493, 600/490, 600/491, 600/492, 600/494, 600/495, 600/499, 600/481, 600/513, 600/500, 600/485
• US Class Current: 600/490
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02255 the pressure being controlled by plethysmographic signals, e.g. derived from optical sensors
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system

Abstract

An apparatus for estimating an intraarterial blood pressure of a living subject, based on information of the subject, including: a first device for obtaining first information which relates to velocity of propagation of a pulse wave; a second device for obtaining at least one of second information which relates to heart rate and third information which relates to an area defined by a volume pulse wave; a third device for estimating, according to a predetermined relationship between (A) blood pressure, and (B1) first information and (B2) at least one of (B21) second information and (B22) third information, the blood pressure of the subject, based on the first information and the at least one of the second and the third information, the relationship being defined by a numerical expression including a plurality of coefficients; a fourth device for determining an activity of an autonomic nerve system, based on at least one of fourth information which relates to fluctuations of the blood pressure and fifth information which relates to fluctuations of the heart rate; and a fifth device for changing, based on the activity of the autonomic nerve system, at least one of the coefficients of the expression, so that the expression including the changed coefficient amplifies a change of an estimated blood pressure from a prior estimated blood pressure.

Claims

1. An apparatus for successively estimating an intraarterial blood pressure of a living subject, based on information non-invasively obtained from a circulatory organ of the subject, comprising:

first means for non-invasively obtaining, from the circulatory organ of the subject, first information which relates to velocity of propagation of a pulse wave which propagates through an artery of the subject;

second means for non-invasively obtaining, from the circulatory organ of the subject, at least one of second information which relates to heart rate of the subject and third information which relates to an area defined by a volume pulse wave from a peripheral portion of the subject;

third means for estimating, according to a predetermined relationship between (A) blood pressure, and (B1) first information and (B2) at least one of (B21) second information and (B22) third information, the intraarterial blood pressure of the subject, based on the first information obtained by the first means and said at least one of the second information and the third information obtained by the second means, the predetermined relationship being defined by a numerical expression including a plurality of coefficients;

fourth means for determining an activity of an autonomic nerve system of the subject, based on at least one of fourth information which relates to fluctuations of the blood pressure of the subject and fifth information which relates to fluctuations of the heart rate of the subject, and

fifth means for changing, based on the determined activity of the autonomic nerve system, at least one of the coefficients of the numerical expression, so that the numerical expression including the changed coefficient amplifies a change of an estimated blood pressure of the subject from a prior estimated blood pressure of the subject.

2. An apparatus according to claim 1, wherein the second means comprises means for obtaining the second information and the third information, and wherein the third means comprises means for estimating, according to the predetermined relationship between (A) blood pressure, and (B1) first information, (B21) second information, and (B22) third information, the intraarterial blood pressure of the subject, based on the obtained first information, the obtained second information, and the obtained third information.

3. An apparatus according to claim 1, wherein the first means comprises means for obtaining, as the first information, a time, DT, needed for the pulse wave to propagate between two different portions of the artery, wherein the second means comprises means for obtaining, as the second information, a heart-beat period, RR, of the subject, and means for obtaining, as the third information, a ratio, VR, of the area of the volume pulse wave to the heart-beat period RR, and wherein the third means comprises means for estimating, according to the predetermined relationship between (A) blood pressure, EBP, and (B1) time DT, (B21) period RR, and (B22) ratio VR, defined by the following numerical expression:

EBP=α

(1/DT)+β

RR+γ

VR+δ

, where α

, β

, and γ

are predetermined coefficients and δ

is a predetermined constant, the intraarterial blood pressure of the subject, based on the obtained time DT, the obtained period RR, and the obtained ratio VR.

4. An apparatus according to claim 3, further comprising a memory which stores data indicative of the coefficients α

, β

, γ

which are predetermined by applying a multiple regression analysis to a plurality of sets of information obtained from at least one living person, each of said sets of information comprising a blood pressure obtained from a corresponding one of the persons, and a time DT, a period RR, and a ratio VR obtained from said one person when the blood pressure is obtained from said one person.

5. An apparatus according to claim 1, wherein the fourth means comprises means for determining an activity of a sympathetic nerve system of the subject based on a low-frequency component which is present in the fluctuations of the blood pressure and whose frequency is lower than a respiration frequency of the subject, and determining an activity of a parasympathetic nerve system of the subject based on a high-frequency component which is present in the fluctuations of the heart rate and whose frequency is around the respiration frequency of the subject, and wherein the fifth means comprises judging means for judging whether the determined activity of the sympathetic nerve system is greater than an upper limit of a first reference range, whether the determined activity of the parasympathetic nerve system is smaller than a lower limit of a second reference range, whether the determined activity of the sympathetic nerve system is smaller than a lower limit of the first reference range, and whether the determined activity of the parasympathetic nerve system is greater than an upper limit of the second reference range, and changing means for changing said at least one coefficient of the numerical expression, to a greater coefficient, when said judging means makes at least one of a first positive judgment that the determined activity of the sympathetic nerve system is greater than the upper limit of the first reference range and a second positive judgment that the determined activity of the parasympathetic nerve system is smaller than the lower limit of the second reference range, and changing said at least one coefficient of the numerical expression, to a smaller coefficient, when said judging means makes at least one of a third positive judgment that the determined activity of the sympathetic nerve system is smaller than the lower limit of the first reference range and a fourth positive judgment that the determined activity of the parasympathetic nerve system is greater than the upper limit of the second reference range.

6. An apparatus according to claim 5, wherein the fifth means does not change said at least one coefficient of the numerical expression to said greater coefficient when said judging means makes a first negative judgment that the determined activity of the sympathetic nerve system is not greater than the upper limit of the first reference range and a second negative judgment that the determined activity of the parasympathetic nerve system is not smaller than the lower limit of the second reference range, and does not change said at least one coefficient of the numerical expression to said smaller coefficient when said judging means makes a third negative judgment that the determined activity of the sympathetic nerve system is not smaller than the lower limit of the first reference range and a fourth negative judgment that the determined activity of the parasympathetic nerve system is not greater than the upper limit of the second reference range.

7. An apparatus according to claim 1, wherein the second means comprises means for obtaining the third information selected from the group consisting of the area defined by the volume pulse wave, a ratio of the area to a heart-beat period of the subject, a ratio of the area to a product of the heart-beat period and an amplitude of the volume pulse wave, and a ratio of a product of the area and the amplitude to the heart-beat period.

8. An apparatus according to claim 1, wherein the first means comprises:

a first pulse-wave sensor and a second pulse-wave sensor which non-invasively detect the pulse wave from two different portions of the artery of the subject, respectively; and

means for determining, as the first information, a time needed for the pulse wave to propagate between the two different portions.

9. An apparatus according to claim 8, wherein the second means comprises means for determining, as the second information, a time difference between respective predetermined points of successive two heartbeat-synchronous pulses of the pulse wave detected by one of the first and second pulse-wave sensors.

10. An apparatus according to claim 8, wherein the second means comprises one of the first and second pulse-wave sensors, said one pulse-wave sensor detecting the volume pulse wave from the peripheral portion of the subject.

11. An apparatus according to claim 8, wherein the first and second pulse-wave sensors comprise an electrocardiograph and a photoelectric oximeter.

12. A method of successively estimating an intraarterial blood pressure of a living subject, based on information non-invasively obtained from a circulatory organ of the subject, comprising the steps of:

non-invasively obtaining, from the circulatory organ of the subject, first information which relates to velocity of propagation of a pulse wave which propagates through an artery of the subject,

non-invasively obtaining, from the circulatory organ of the subject, at least one of second information which relates to heart rate of the subject and third information which relates to an area defined by a volume pulse wave from a peripheral portion of the subject,

estimating, according to a predetermined relationship between (A) blood pressure, and (B1) first information and (B2) at least one of (B21) second information and (B22) third information, the intraarterial blood pressure of the subject, based on the obtained first information and the obtained at least one of the second information and the third information, the predetermined relationship being defined by a numerical expression including a plurality of coefficients,

determining an activity of an autonomic nerve system of the subject, based on at least one of fourth information which relates to fluctuations of the blood pressure of the subject and fifth information which relates to fluctuations of the heart rate of the subject, and

changing, based on the determined activity of the autonomic nerve system, at least one of the coefficients of the numerical expression, so that the numerical expression including the changed coefficient amplifies a change of an estimated blood pressure of the subject from a prior estimated blood pressure of the subject.

13. A method according to claim 12, wherein the step of obtaining said at least one of the second information and the third information comprises obtaining the second information and the third information, and wherein the step of estimating the intraarterial blood pressure of the subject comprises estimating, according to the predetermined relationship between (A) blood pressure, and (B1) first information, (B21) second information, and (B22) third information, the intraarterial blood pressure of the subject, based on the obtained first information, the obtained second information, and the obtained third information.

14. A method according to claim 12, wherein the step of obtaining the first information comprises obtaining a time, DT, needed for the pulse wave to propagate between two different portions of the artery, wherein the step of obtaining said at least one of the second information and the third information comprises obtaining, as the second information, a heart-beat period, RR, of the subject and obtaining, as the third information, a ratio, VR, of the area of the volume pulse wave to the heart-beat period RR, and wherein the step of estimating the intraarterial blood pressure of the subject comprises estimating, according to the predetermined relationship between (A) blood pressure, EBP, and (B1) time DT, (B21) period RR, and (B22) ratio VR, defined by the following numerical expression:

EBP=α

(1/DT)+β

RR+γ

VR+δ

, where α

, β

, and γ

are predetermined coefficients and δ

is a predetermined constant, the intraarterial blood pressure of the subject, based on the obtained time DT, the obtained period RR, and the obtained ratio VR.

15. A method according to claim 14, further comprising a step of determining the coefficients α

, β

, γ

by applying a multiple regression analysis to a plurality of sets of information obtained from at least one living person, each of said sets of information comprising a blood pressure obtained from a corresponding one of the persons, and a time DT, a period RR, and a ratio VR obtained from said one person when the blood pressure is obtained from said one person.

16. A method according to claim 12, wherein the step of determining the activity of the autonomic nerve system comprises determining an activity of a sympathetic nerve system of the subject based on a low-frequency component which is present in the fluctuations of the blood pressure and whose frequency is lower than a respiration frequency of the subject, and determining an activity of a parasympathetic nerve system of the subject based on a high-frequency component which is present in the fluctuations of the heart rate and whose frequency is around the respiration frequency of the subject, and wherein the step of changing said at least one coefficient of the numerical expression comprises judging whether the determined activity of the sympathetic nerve system is greater than an upper limit of a first reference range, whether the determined activity of the parasympathetic nerve system is smaller than a lower limit of a second reference range, whether the determined activity of the sympathetic nerve system is smaller than a lower limit of the first reference range, and whether the determined activity of the parasympathetic nerve system is greater than an upper limit of the second reference range, and changing said at least one coefficient of the numerical expression, to a greater coefficient, when at least one of a first positive judgment that the determined activity of the sympathetic nerve system is greater than the upper limit of the first reference range and a second positive judgment that the determined activity of the parasympathetic nerve system is smaller than the lower limit of the second reference range is made, and changing said at least one coefficient of the numerical expression, to a smaller coefficient, when at least one of a third positive judgment that the determined activity of the sympathetic nerve system is smaller than the lower limit of the first reference range and a fourth positive judgment that the determined activity of the parasympathetic nerve system is greater than the upper limit of the second reference range is made.

17. A method according to claim 16, wherein said at least one coefficient of the numerical expression is not changed to said greater coefficient, when a first negative judgment that the determined activity of the sympathetic nerve system is not greater than the upper limit of the first reference range and a second negative judgment that the determined activity of the parasympathetic nerve system is not smaller than the lower limit of the second reference range are made, and said at least one coefficient of the numerical expression is not changed to said smaller coefficient, when a third negative judgment that the determined activity of the sympathetic nerve system is not smaller than the lower limit of the first reference range and a fourth negative judgment that the determined activity of the parasympathetic nerve system is not greater than the upper limit of the second reference range are made.

18. A method according to claim 12, wherein the step of obtaining said at least one of the second information and the third information comprises obtaining the third information selected from the group consisting of the area defined by the volume pulse wave, a ratio of the area to a heart-beat period of the subject, a ratio of the area to a product of the heart-beat period and an amplitude of the volume pulse wave, and a ratio of a product of the area and the amplitude to the heart-beat period.